Abstract:
:Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. The first EEG change, slowing was occasional spikes, was seen at serum levels of 75 mug per milliliter. Changes in the recordings progressed through a number of stages, culminating in bursts of poly spiking interspersed among periods of electrical silence first seen at 350 mug per milliliter. Behavior was characterized by a progressively deepening trancelike state punctuated at higher serum levels by spontaneous and stimulus-induced myoclonic jerks. These changes were correlated with serum levels and are more similar to petit mal stupor than any kind of natural sleep-like state previously used to describe them.
journal_name
Neurologyjournal_title
Neurologyauthors
Snead OC 3rd,Yu RK,Huttenlocher PRdoi
10.1212/wnl.26.1.51subject
Has Abstractpub_date
1976-01-01 00:00:00pages
51-6issue
1eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
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