Abstract:
:We investigated the relationship between the rate of motor response after a standard levodopa oral dose and drug dynamic variables and disease-related factors in 66 patients with Parkinson's disease. Time to maximum finger tapping effect was positively correlated with matched duration of levodopa dose response and fell from a median 120 minutes in patients at Hoehn and Yahr stage I and II to 60 minutes in stage IV patients (p < 0.001). The accelerated response to levodopa dose with the advancement of disease was also apparent as an increased steepness of the tapping effect versus time curve, with a shift from a hyperbolic to a sigmoid profile. The rate of motor response to oral levodopa may reflect the rate of dopamine interaction with the postsynaptic receptors, providing an indirect objective index of presynaptic dopaminergic homeostasis.
journal_name
Neurologyjournal_title
Neurologyauthors
Contin M,Riva R,Martinelli P,Triggs EJ,Albani F,Baruzzi Adoi
10.1212/wnl.46.4.1055subject
Has Abstractpub_date
1996-04-01 00:00:00pages
1055-8issue
4eissn
0028-3878issn
1526-632Xjournal_volume
46pub_type
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