Abstract:
:Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.
journal_name
Neurologyjournal_title
Neurologyauthors
Sprenger T,Willoch F,Miederer M,Schindler F,Valet M,Berthele A,Spilker ME,Förderreuther S,Straube A,Stangier I,Wester HJ,Tölle TRdoi
10.1212/01.wnl.0000204225.15947.f8subject
Has Abstractpub_date
2006-04-11 00:00:00pages
1108-10issue
7eissn
0028-3878issn
1526-632Xpii
66/7/1108journal_volume
66pub_type
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