Head trauma preceding PD: a case-control study.

abstract：:In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...

journal_title：Neurology

authors： Weber D,Sarva H,Weaver J,Wang F,Chou J,Cornes S,Nickels K,Safdieh JE,Poncelet A,Stern BJ

更新日期：2019-07-02 00:00:00

abstract：:We studied the eye movements and visual perception in a man with extensive bilateral occipital lesions acquired at birth. He had 3/500 acuity, limited visual fields, and extrafoveal fixation attributable to an intact left superior visual cortex. Analysis of digitized electro-oculography and magnetic search coil data s...

journal_title：Neurology

authors： Rizzo M,Hurtig R

更新日期：1989-03-01 00:00:00

abstract：:We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...

journal_title：Neurology

authors： McGeer PL,Itagaki S,Boyes BE,McGeer EG

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE). METHODS:This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatr...

journal_title：Neurology

authors： Sánchez Fernández I,Jackson MC,Abend NS,Arya R,Brenton JN,Carpenter JL,Chapman KE,Gaillard WD,Gaínza-Lein M,Glauser TA,Goldstein JL,Goodkin HP,Helseth A,Kapur K,McDonough TL,Mikati MA,Peariso K,Riviello J Jr,Tasker RC

更新日期：2017-01-24 00:00:00

abstract：OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...

journal_title：Neurology

authors： Burman J,Zelano J

更新日期：2017-12-12 00:00:00

abstract：:Pergolide, a long-acting central dopamine agonist, was used as monotherapy in 16 parkinsonian patients. A mean daily dose of 6.3 mg resulted in 73% improvement of parkinsonian disability. Clinical improvement after acute administration of one dose of pergolide was similar to that observed after levodopa plus a periphe...

journal_title：Neurology

authors： Mear JY,Barroche G,de Smet Y,Weber M,Lhermitte F,Agid Y

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. The ALS CARE Database has been collecting data on the management of patients with ALS in North America since 1996. OBJECTIVE:To compare the management of patients with ALS in North America as recorded in the ALS CARE...

journal_title：Neurology

authors： Bradley WG,Anderson F,Bromberg M,Gutmann L,Harati Y,Ross M,Miller RG,ALS CARE Study Group.

更新日期：2001-08-14 00:00:00

abstract：OBJECTIVE:To evaluate the risk of relapses during pregnancy and in the first 3 months after delivery in 2 successive pregnancies in a cohort of French and Italian women with multiple sclerosis (MS). METHODS:A total of 93 women were included if they had had 2 pregnancies followed prospectively after MS onset between Ja...

journal_title：Neurology

authors： Benoit A,Durand-Dubief F,Amato MP,Portaccio E,Casey R,Roggerone S,Androdias G,Gignoux L,Ionescu I,Marrosu MG,Cocco E,Ghezzi A,Annovazzi P,Trojano M,Simone M,Marignier R,Confavreux C,Vukusic S

更新日期：2016-09-27 00:00:00

abstract：:Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...

journal_title：Neurology

authors： Sabra AF,Hallett M,Sudarsky L,Mullally W

更新日期：1982-08-01 00:00:00

abstract：:Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with lubag and two of his female first cousins. Genetic typing was carried out using X chromosome markers. Fluorodopa PET was perfo...

journal_title：Neurology

authors： Waters CH,Takahashi H,Wilhelmsen KC,Shubin R,Snow BJ,Nygaard TG,Moskowitz CB,Fahn S,Calne DB

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:To quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles. METHODS:MRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with DMD and 51 healthy controls using a prospective observational stu...

journal_title：Neurology

authors： Rooney WD,Berlow YA,Triplett WT,Forbes SC,Willcocks RJ,Wang DJ,Arpan I,Arora H,Senesac C,Lott DJ,Tennekoon G,Finkel R,Russman BS,Finanger EL,Chakraborty S,O'Brien E,Moloney B,Barnard A,Sweeney HL,Daniels MJ,Walter

更新日期：2020-04-14 00:00:00

abstract：OBJECTIVE:The human GABAAγ2(R43Q) mutation is associated with genetic epilepsy. Because of the role of γ-aminobutyric acid (GABA) in brain development, we asked whether this epilepsy mutation might affect excitability by changing cortical cytoarchitecture. METHODS:We used a mouse model harboring a heterozygous R43Q mi...

journal_title：Neurology

authors： Wimmer VC,Li MY,Berkovic SF,Petrou S

更新日期：2015-03-31 00:00:00

abstract：:Restless legs syndrome (RLS) is characterized by an urge to move the legs. The symptoms are more intense in the evening and during periods of inactivity. RLS symptoms are relieved by movement. It is classified as a sleep disorder, but in many ways it is actually a disorder of wakefulness that seems to intrude upon the...

journal_title：Neurology

authors： Auerbach S,Walters AS

更新日期：2014-04-08 00:00:00

abstract：:Thirteen consecutive patients with thalamic deep brain stimulation (DBS) were examined serially for 3 to 5 years. Initially, all demonstrated at least 50% improvement in contralateral tremor. At last follow-up, three of eight patients with Parkinson disease no longer used DBS because tremor had markedly improved, and ...

journal_title：Neurology

authors： Kumar R,Lozano AM,Sime E,Lang AE

更新日期：2003-12-09 00:00:00

abstract：OBJECTIVE:To assess the surgical and hardware complications in a series of 81 consecutive patients undergoing subthalamic (STN) deep brain stimulation (DBS) for Parkinson disease (PD). METHODS:The authors prospectively documented surgical and hardware complications occurring at the time of surgery and at subsequent ne...

journal_title：Neurology

authors： Lyons KE,Wilkinson SB,Overman J,Pahwa R

更新日期：2004-08-24 00:00:00

abstract：OBJECTIVE:There is a high risk of readmission within 30 days of index acute ischemic stroke (AIS), but effect of readmission to a different hospital is not known. We performed a retrospective cohort study to assess our hypothesis that 30-day readmission outcomes after AIS are worse for those readmitted to another hospi...

journal_title：Neurology

authors： Stein LK,Agarwal P,Thaler A,Kwon CS,Jette N,Dhamoon MS

更新日期：2019-11-12 00:00:00

abstract：OBJECTIVE:To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD. BACKGROUND:GDNF is a peptide that promotes survival of dopamine neurons. It improved 6-OHDA- or...

journal_title：Neurology

authors： Nutt JG,Burchiel KJ,Comella CL,Jankovic J,Lang AE,Laws ER Jr,Lozano AM,Penn RD,Simpson RK Jr,Stacy M,Wooten GF,ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor.

更新日期：2003-01-14 00:00:00

abstract：OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...

journal_title：Neurology

authors： Iglesias S,Chapon F,Baron JC

更新日期：2000-12-12 00:00:00

abstract：:Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Fi...

journal_title：Neurology

authors： Ropper AH,Kehne SM,Wechsler L

更新日期：1987-11-01 00:00:00

abstract：:The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2...

journal_title：Neurology

authors： Frontera JA,Rundek T,Schmidt JM,Claassen J,Parra A,Wartenberg KE,Temes RE,Mayer SA,Mohr JP,Marshall RS

更新日期：2006-03-14 00:00:00

abstract：:Clinical, electrodiagnostic, and pathologic studies indicate that the Guillain-Barre syndromes (GBSs) include both primary demyelinating and primary axonal forms. The axonal forms are usually thought to have a poorer prognosis, with less chance for rapid or complete recovery. In northern China, epidemics of one axonal...

journal_title：Neurology

authors： Ho TW,Li CY,Cornblath DR,Gao CY,Asbury AK,Griffin JW,McKhann GM

更新日期：1997-03-01 00:00:00

abstract：:The authors report two patients with suspected brain death who required confirmatory tests other than clinical examination because of prolonged barbiturate administration for intracranial hypertension. Absence of intracranial blood flow was documented on CT angiography and confirmed by CT perfusion images. Cerebral an...

journal_title：Neurology

authors： Qureshi AI,Kirmani JF,Xavier AR,Siddiqui AM

更新日期：2004-02-24 00:00:00

abstract：:Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders will be treated by physicians and primary care providers witho...

journal_title：Neurology

authors： Sandrone S,Berthaud JV,Chuquilin M,Cios J,Ghosh P,Gottlieb-Smith RJ,Kushlaf H,Mantri S,Masangkay N,Menkes DL,Nevel KS,Sarva H,Schneider LD

更新日期：2019-01-22 00:00:00

abstract：OBJECTIVES:Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. METHODS:Between 2005 and 2007, survivors o...

journal_title：Neurology

authors： Postels DG,Taylor TE,Molyneux M,Mannor K,Kaplan PW,Seydel KB,Chimalizeni YF,Kawaza K,Birbeck GL

更新日期：2012-09-18 00:00:00

abstract：:The authors describe a case of syphilitic amyotrophy in a 37-year-old man presenting with subacute progressive painless weakness in the right arm. Syphilitic amyotrophy is still an existing differential diagnosis of painless and progressive weakness. The authors explore potential obstacles in the diagnostic workup and...

journal_title：Neurology

authors： Etgen T,Bischoff C,Resch M,Winbeck K,Conrad B,Sander D

更新日期：2003-02-11 00:00:00

abstract：:One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (C...

journal_title：Neurology

authors： Fuccillo DA,Madden DL,Castellano GA,Uhlig L,Traub RG,Mattson J,Krezlewicz A,Sever JL

更新日期：1978-06-01 00:00:00

abstract：:CSF lymphocyte subpopulations of eight patients with neurosarcoidosis were examined. CSF or CT was abnormal in all. The CSF T4/T8 (helper/suppressor) ratio was elevated at 6.8 and 7.6 in two patients; in one, there were only CSF T4 cells. The ratio was normal in five patients. ...

journal_title：Neurology

authors： Stern BJ,Griffin DE,Luke RA,Krumholz A,Johns CJ

更新日期：1987-05-01 00:00:00

abstract：:Medical therapy is the mainstay for epilepsy, with most patients well controlled on a single antiepileptic drug (AED). In this non-refractory group, many patients have medication side effects and occasional seizures. Approximately 30% of patients with partial epilepsy and 25% of patients with generalized epilepsy are ...

journal_title：Neurology

authors： Nadkarni S,LaJoie J,Devinsky O

更新日期：2005-06-28 00:00:00

abstract：OBJECTIVE:To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region. DESIGN:A family history questionnaire was used to obtain information on all first-degree relatives ...

journal_title：Neurology

authors： Marder K,Tang MX,Mejia H,Alfaro B,Côté L,Louis E,Groves J,Mayeux R

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To report the development of CNS vasculitis in a patient with multiple sclerosis (MS) treated with daclizumab. METHODS:This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. RESULTS:After completing a phase II daclizumab monotherapy study with an optimal response as evidenced ...

journal_title：Neurology

authors： Ohayon J,Oh U,Richert N,Martin J,Vortmeyer A,McFarland H,Bielekova B

更新日期：2013-01-29 00:00:00