Abstract:
:The objective of our study was to assess the 5-year risk of and prognostic factors for the development of clinically definite multiple sclerosis (CDMS) following optic neuritis. In a prospective cohort study design, 388 patients, who did not have probable or definite MS at study entry enrolled in the Optic Neuritis Treatment Trial between 1988 and 1991, and were followed for the development of CDMS. The 5-year cumulative probability of CDMS was 30% and did not differ by treatment group. Neurologic impairment in the patients who developed CDMS was generally mild. Brain MRI performed at study entry was a strong predictor of CDMS, with the 5-year risk of CDMS ranging from 16% in the 202 patients with no MRI lesions to 51% in the 89 patients with three or more MRI lesions. Independent of brain MRI, the presence of prior nonspecific neurologic symptoms was also predictive of the development of CDMS. Lack of pain, the presence of optic disk swelling, and mild visual acuity loss were features of the optic neuritis associated with a low risk of CDMS among the 189 patients who had no brain MRI lesions and no history of neurologic symptoms or optic neuritis in the fellow eye. The 5-year risk of CDMS following optic neuritis is highly dependent on the number of lesions present on brain MRI. However, even a normal brain MRI does not preclude the development of CDMS. In these patients with no brain MRI lesions, certain clinical features identify a subgroup with a particularly low 5-year risk of CDMS.
journal_name
Neurologyjournal_title
Neurologyauthors
Optic Neuritis Study Group.doi
10.1212/wnl.49.5.1404subject
Has Abstractpub_date
1997-11-01 00:00:00pages
1404-13issue
5eissn
0028-3878issn
1526-632Xjournal_volume
49pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Physicians are often asked to predict outcome after acute stroke. Very little information is available that can reliably predict the likelihood of severe disability or death. OBJECTIVE:To develop a practical method for predicting a poor outcome after acute ischemic stroke. METHODS:Data from the placebo arm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.952
更新日期:2000-10-10 00:00:00
abstract::A 25-year-old woman with Kearns-Sayre syndrome (KSS) had complete external ophthalmoplegia, short stature, ataxia, cardiac conduction defects, and pigmentary retinopathy. Muscle biopsy revealed ragged-red fibers. Electron microscopy showed increased numbers of mitochondria with disordered structure and paracrystalline...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.5.693
更新日期:1989-05-01 00:00:00
abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277455.08067.9c
更新日期:2007-10-02 00:00:00
abstract:OBJECTIVE:To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and to determine their predictive values for the early development of clinical MS. BACKGROUND:Disseminated lesions on T2-weighted brain...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.6.1184
更新日期:1999-10-12 00:00:00
abstract:OBJECTIVE:To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method. METHODS:The study population consisted of 597 patients with MS and 104 control subjects....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000168837.87351.1f
更新日期:2005-07-26 00:00:00
abstract::Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.5.664
更新日期:2002-09-10 00:00:00
abstract:OBJECTIVE:To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness. BACKGROUND:Neuropathologic alterations in AD precede cognitive impairment by several years. It is unknown whether functional alterations in neur...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1391
更新日期:1999-10-22 00:00:00
abstract::Moderate hypothermia (33 degrees C) was induced for 7 and 3 days, respectively, in two patients with multiple sclerosis. In both patients, striking improvement of clinical signs persisted throughout the period of cooling, indicating the potential for sustained reversal of the neurologic deficit. Hypothermia may aid ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.3.302
更新日期:1977-03-01 00:00:00
abstract::We studied the scalp distribution of auditory event-related potentials (P300), using simultaneously a cephalic (linked ears) and a noncephalic (balanced sternovertebra) reference. The recordings with noncephalic reference showed that infrequent, attended auditory stimuli evoke a negative bitemporal component (N300) as...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1803
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:To determine the associations between amyloid-PET, tau-PET, and atrophy with the behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms. METHODS:We assessed 15 patients with behavioral/dysexecutive AD recruited from a ter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011081
更新日期:2021-01-05 00:00:00
abstract::One hundred and eight patients with independent, multifocal, spike discharges in the EEG were studied. The abnormality occurred at all ages but was more frequent between 4 and 7 years. The basic EEG activity in wake tracing was invariably slow for the age of the patient. The majority of the patients with independent m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.7.667
更新日期:1976-07-01 00:00:00
abstract::Cholinergic neurons in the nucleus ambiguus (NA) were counted in autopsy tissue obtained from five patients with multiple system atrophy (MSA), four patients with PD, and five controls. The number of neurons in the dorsal NA was not significantly different among the three groups. Neurons in the ventrolateral portion o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000042087.07133.87
更新日期:2003-01-14 00:00:00
abstract:OBJECTIVE:To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy. METHODS:This was a double-blind, randomized, single-dose, 3-period crossover study in patients with epilepsy and chronic cognitive complaints comparing the effects of placebo and MPH 10 ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000003564
更新日期:2017-01-31 00:00:00
abstract::In 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 11 patients with chronic idiopathic axonal polyneuropathy (CIAP), absent myotatic reflexes were significantly associated more often with CIDP than with CIAP, an absent biceps-reflex having the highest sensitivity and specificity for the d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1573
更新日期:1999-10-22 00:00:00
abstract::Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1724
更新日期:2000-12-12 00:00:00
abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824528b2
更新日期:2012-01-31 00:00:00
abstract::Spinal muscular atrophy (SMA) is the most common fatal neuromuscular disease of infancy. SMA type I is the most severe and mortality is usually due to respiratory failure. In type II the disability is of later onset and less severe, and prognosis has improved primarily due to supportive care. Type III is the mildest f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183282.10946.c7
更新日期:2005-11-08 00:00:00
abstract:BACKGROUND:Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. METHODS:We prospectively examined a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bd13a1
更新日期:2009-10-20 00:00:00
abstract::Rates of temporal horn volume change were significantly greater in the subjects with mild cognitive impairment who were developing dementia vs those who remained stable. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000194213.50222.1a
更新日期:2006-01-24 00:00:00
abstract:OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000009859
更新日期:2020-10-20 00:00:00
abstract:OBJECTIVES:Laminin alpha2 deficiency presents at birth with muscle weakness, hypotonia, and usually asymptomatic white matter signal on MRI. Few patients with laminin alpha2 deficiency have been described with seizures and structural brain abnormalities. The reason for the variation in the severity of the clinical phen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.8.1128
更新日期:2000-10-24 00:00:00
abstract:OBJECTIVE:To compare the sensitivity of structural MRI and 18F-fludeoxyglucose PET (18FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD). METHODS:Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009760
更新日期:2020-07-14 00:00:00
abstract:OBJECTIVE:To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS:A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 200...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007035
更新日期:2019-03-05 00:00:00
abstract::Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the path...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000204225.15947.f8
更新日期:2006-04-11 00:00:00
abstract::Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Fi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.11.1733
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006361
更新日期:2018-10-16 00:00:00
abstract:OBJECTIVE:To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype. BACKGROUND:The apoE-4 allele is an important risk factor for AD. PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral met...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.1.201
更新日期:1999-07-13 00:00:00
abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260610.79853.47
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008359
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Although hospital-outcome relationships have been explored for a variety of procedures and interventions, little is known about the association between annual stroke admission volumes and stroke mortality. Our aim was to determine whether facility type and hospital volume was associated with stroke mortality...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000268485.93349.58
更新日期:2007-09-11 00:00:00