当前位置： SCI文献检索 > NEUROLOGY期刊下所有文献 > Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study.

Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study.

Abstract：

OBJECTIVE:To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy. METHODS:This was a double-blind, randomized, single-dose, 3-period crossover study in patients with epilepsy and chronic cognitive complaints comparing the effects of placebo and MPH 10 and 20 mg given 1 week apart. Cognitive outcome was evaluated on the basis of an omnibus z score calculated from performance on the Conners Continuous Performance Test 3 (ability to discriminate between target and nontarget stimuli [d'] and hit reaction time standard deviation), Symbol-Digit Modalities Test, and Medical College of Georgia Paragraph Memory Test. Adverse events and seizure frequency were monitored. An open-label follow-up is reported elsewhere. RESULTS:Thirty-five adult patients with epilepsy participated, of whom 31 finished. Demographics included the following: mean age = 35.3 years (range 20-62 years), 13 men and 18 women, and baseline seizure frequency of 2.8 per month. Epilepsy types were focal (n = 24), generalized (n = 6), or unclassified (n = 1). Mean epilepsy duration was 12.5 years. A statistically significant performance benefit was present at both 10-mg (p = 0.030) and 20-mg (p = 0.034) MPH doses. No seizures were associated with either MPH dose. Adverse effects leading to withdrawal included cognitive "fogginess" (n = 1 on 20 mg), anxiety/agitation (n = 1 on 10 mg), and tachycardia (n = 1). One participant was lost to follow-up after one 20-mg dose without side effect. CONCLUSIONS:This single-dose study suggests that MPH may be effective in ameliorating some cognitive deficits in patients with epilepsy. Additional studies are required. CLINICALTRIALSGOV IDENTIFIER:NCT02178995. CLASSIFICATION OF EVIDENCE:This study provides Class II evidence that single doses of MPH improve cognitive performance on some measures of attention and processing speed in patients with epilepsy and cognitive complaints.

journal_name

Neurology

journal_title

Neurology

authors

Adams J,Alipio-Jocson V,Inoyama K,Bartlett V,Sandhu S,Oso J,Barry JJ,Loring DW,Meador K

doi

10.1212/WNL.0000000000003564

subject

Has Abstract

pub_date

2017-01-31 00:00:00

pages

470-476

issue

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000003564

journal_volume

pub_type

杂志文章,随机对照试验

在线工具

Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study.