Abstract:
:In clinical trials, copolymer I (Cop 1) appears to reduce the number of exacerbations in early relapsing-remitting multiple sclerosis. The mechanism of this effect is uncertain, but Cop 1 also reduces the severity of experimental allergic encephalomyelitis and inhibits the response of murine myelin basic protein (MBP)-specific T cells. We tested MBP-specific T-cell lines and clones from four subjects to determine whether Cop 1 also limits the human response to MBP. We found no inhibition by Cop 1 of the human T-cell response to MBP.
journal_name
Neurologyjournal_title
Neurologyauthors
Burns J,Littlefield Kdoi
10.1212/wnl.41.8.1317subject
Has Abstractpub_date
1991-08-01 00:00:00pages
1317-9issue
8eissn
0028-3878issn
1526-632Xjournal_volume
41pub_type
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