Abstract:
OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I² methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g. RESULTS:Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D <50 nmol/L to those with values ≥50 nmol/L. There was significant heterogeneity among the studies that compared the WMD for MMSE but an overall positive effect for the higher vitamin D group (1.2, 95% confidence interval [CI] 0.5 to 1.9; I² = 0.65; p = 0.002). The small positive effect persisted despite several sensitivity analyses. Six studies presented data comparing Alzheimer disease (AD) to controls but 2 utilized a method withdrawn from commercial use. For the remaining 4 studies the AD group had a lower vitamin D concentration compared to the control group (WMD = -6.2 nmol/L, 95% CI -10.6 to -1.8) with no heterogeneity (I² < 0.01; p = 0.53). CONCLUSION:These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD. Further studies are required to determine the significance and potential public health benefit of this association.
journal_name
Neurologyjournal_title
Neurologyauthors
Balion C,Griffith LE,Strifler L,Henderson M,Patterson C,Heckman G,Llewellyn DJ,Raina Pdoi
10.1212/WNL.0b013e31826c197fsubject
Has Abstractpub_date
2012-09-25 00:00:00pages
1397-405issue
13eissn
0028-3878issn
1526-632Xpii
79/13/1397journal_volume
79pub_type
杂志文章,meta分析,评审相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients. Our aim was to analyze the contribution of SC involvement in clinically isolated syndrome (CIS) in diagnosing MS according the McDonald 2010 criteria and in predicting conversi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b1a67
更新日期:2013-01-01 00:00:00
abstract::A prospective trial of plasmapheresis and azathioprine or azathioprine alone was carrier out on 20 patients with chronic progressive MS. Seven of 10 patients in each group continued therapy for 12 months. When the groups were compared by disability ratings, the combination of plasmapheresis and azathioprine was no bet...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.7.739
更新日期:1982-07-01 00:00:00
abstract:OBJECTIVE:To describe a clinical syndrome of cerebellar ataxia associated with muscle coenzyme Q10 (CoQ10) deficiency. BACKGROUND:Muscle CoQ10 deficiency has been reported only in a few patients with a mitochondrial encephalomyopathy characterized by 1) recurrent myoglobinuria; 2) brain involvement (seizures, ataxia, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.7.849
更新日期:2001-04-10 00:00:00
abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007968
更新日期:2019-08-20 00:00:00
abstract::A 60-year-old woman suffered from recurrent episodes of fever, hypertension, facial flushing, vomiting, stridor, slowly progressive symptoms of hypohidrosis, and orthostatic hypotension. The episodes were synchronous with elevated catecholamine concentration in plasma and urine. This is an example of paroxysmal autono...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1823
更新日期:1993-09-01 00:00:00
abstract::Patients, clinicians, and hospitals have undergone monumental changes during the coronavirus disease 2019 (COVID-19) pandemic. This crisis has forced us to consider the obligations that we neurologists have to our individual patients as well as the greater community. By returning to our fundamental understanding of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009744
更新日期:2020-07-28 00:00:00
abstract:BACKGROUND:While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318212ab0c
更新日期:2011-03-29 00:00:00
abstract:OBJECTIVES:To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)-ALS-frontotemporal dementia (FTD) continuum using multiple, complementary imaging techniques. METHODS:Sixty-seven C9orf72-negative patients with ALS and 39 healthy controls were included in a cross-sectional quantitative MRI stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002017
更新日期:2015-10-13 00:00:00
abstract:OBJECTIVE:To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). METHODS:NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors usin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005792
更新日期:2018-07-10 00:00:00
abstract::Restless legs syndrome (RLS) is a common neurologic disorder whose prevalence has been estimated at 4 to 10% of the general population. Although its pathophysiology remains unknown, dopaminergic mechanisms are believed to play a central role. Furthermore, dopaminergic drugs have shown therapeutic efficacy in various l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.61.6_suppl_3.s49
更新日期:2003-09-23 00:00:00
abstract::We studied brain sections from 10 patients with the acquired immunodeficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML) by in situ hybridization with a biotin-labeled JC virus (JCV) DNA probe and by immunohistochemistry using antibody against the JCV capsid antigen. We compared the results w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1073
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To assess if multifocal motor neuropathy (MMN) with and MMN without conduction block (CB) are similar or distinct diseases. METHODS:The authors reviewed the clinical features and responses to IV immunoglobulin (IVIg) treatment of patients with MMN with and without CB at diagnosis, after 4 years of follow-up ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000234063.51897.20
更新日期:2006-08-22 00:00:00
abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000115097.61748.bf
更新日期:2004-03-23 00:00:00
abstract::Patients with frontal lobe dementia (FLD) include those who suffer from Pick's disease, corticobasal degeneration, FLD without specific histopathologic features, as well as the infrequent families with frontotemporal dementia and parkinsonism associated with chromosome 17. Currently there have been no systematic effor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.suppl_4.s41
更新日期:2001-06-01 00:00:00
abstract::IgM anti-GM1 antibodies occur with increased frequency in the serum of patients with multifocal motor neuropathy (MMN). We tested the ability of serum IgM from patients with MMN to bind to GM1 ganglioside covalently bound to secondary amino groups on ELISA plates (Co-GM1). The Co-GM1 technique detected high titer (> 1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1289
更新日期:1997-11-01 00:00:00
abstract::The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.321
更新日期:2001-07-24 00:00:00
abstract:BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327643.05073.eb
更新日期:2008-10-14 00:00:00
abstract:BACKGROUND:Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. OBJECTIVE:To determine if neurocognitive deficits persist in 28-day abstinent heavy marijuana users and if these deficits are dose-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031422.66442.49
更新日期:2002-11-12 00:00:00
abstract::The position of the auditory pathways in the human corpus callosum has not been defined by modern imaging techniques. We report a case with a discrete hemorrhagic lesion in the posterior body of the corpus callosum. The only signs of disturbed callosal function were limited to the auditory system--suppression of left ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.5.802
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. METHODS:As proof of principle, 22 patients with well-compensated, biopsy-proven cirrhosis of differing etiology and previous minimal hepat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828726e1
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003512
更新日期:2017-01-17 00:00:00
abstract::Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.10.1872
更新日期:1994-10-01 00:00:00
abstract::Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219812.20616.b3
更新日期:2006-06-27 00:00:00
abstract:BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e074a7
更新日期:2010-05-18 00:00:00
abstract::We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the paren...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1639
更新日期:1991-10-01 00:00:00
abstract::We report the clinical and neuroimaging findings of a mother and daughter with seizure disorders and band heterotopias seen on magnetic resonance imaging studies. These clinicoradiologic findings simulate those for a diagnosis of tuberous sclerosis complex. Clinicians should be aware of this migrational anomaly and it...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1424
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS:Individual participant data were obtained from 3 randomized trials investigating the effic...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0000000000004606
更新日期:2017-10-31 00:00:00
abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.885
更新日期:1998-09-01 00:00:00
abstract::The forearm segment of the ulnar nerve is difficult to assess if the nerve has been injured severely at the wrist. A new, simple nerve conduction technique of recording from the sensory dorsal branch of the nerve localizes the lesion and enables easier evaluation of that segment than do other techniques. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.8.873
更新日期:1980-08-01 00:00:00
abstract::We examined the baseline characteristics of patients in the Ticlopidine Aspirin Stroke Study (TASS) to determine if the effects of the two treatments in preventing stroke differed in various subgroups. Patients with the following characteristics did less well on aspirin: elevated creatinine, hypertension or diabetes r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.111
更新日期:1992-01-01 00:00:00