Transient ischemic attacks: a prospective study of 225 patients.


:Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and nine from other causes. Of the 56 untreated patients, 11 (19 percent) had cerebral infarctions, four (7 percent) of which were fatal; six (11 percent) were still having TIAs. Of the 45 patients medically treated, 10 (24 percent) had cerebral infarctions, three (7 percent) of which were fatal; 11(25 percent) still experienced TIAs. In the surgical group of 124, 27 (21 percent) had postoperative cerebral infarctions, seven (6 percent) of which were fatal; 23 (18 percent) had cerebral infarctions during follow-up, of which seven (6 percent) were fatal; and 15 (12 percent) were still having TIAs. No statistically significant differences (p less than 0.05) related to cerebral infarction or TIAs developed among the three groups. The majority (23 percent) eventually succumbed to myocardial infarction, leading us to conclude that great emphasis must be placed upon TIAs as a warning for cardiac as well as cerebrovascular disease.






Toole JF,Yuson CP,Janeway R,Johnston F,Davis C,Cordell AR,Howard G




Has Abstract


1978-08-01 00:00:00












  • Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US study.

    abstract:OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...


    pub_type: 杂志文章


    authors: Chandra V,Ganguli M,Pandav R,Johnston J,Belle S,DeKosky ST

    更新日期:1998-10-01 00:00:00

  • Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study.

    abstract:OBJECTIVE:To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS:The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995....


    pub_type: 杂志文章


    authors: Benedetti MD,Bower JH,Maraganore DM,McDonnell SK,Peterson BJ,Ahlskog JE,Schaid DJ,Rocca WA

    更新日期:2000-11-14 00:00:00

  • Localizing value of torsional nystagmus in small midbrain lesions.

    abstract:BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...


    pub_type: 临床试验,杂志文章


    authors: Helmchen C,Rambold H,Kempermann U,Büttner-Ennever JA,Büttner U

    更新日期:2002-12-24 00:00:00

  • Contrast agent overdose causing brain retention of contrast, seizures and parkinsonism.

    abstract::A patient received an overdose of intravascular contrast medium and experienced protracted seizures associated with radiographic evidence of prolonged retention of the contrast agent in the cerebral cortex, basal ganglia, and thalami. This is only the second report and the first survivor of a similar neurologic syndro...


    pub_type: 杂志文章


    authors: May EF,Ling GS,Geyer CA,Jabbari B

    更新日期:1993-04-01 00:00:00

  • Efficacy of rapid IV administration of valproic acid for status epilepticus.

    abstract::Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...


    pub_type: 杂志文章,评审


    authors: Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JG

    更新日期:2005-01-25 00:00:00

  • Blink reflex excitability cycle in hemifacial spasm.

    abstract::We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...


    pub_type: 杂志文章


    authors: Valls-Sole J,Tolosa ES

    更新日期:1989-08-01 00:00:00

  • Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women.

    abstract:OBJECTIVE:To describe neurodevelopment and head growth in HIV-1-infected and exposed uninfected infants with and without in utero exposure to opiates and cocaine. METHODS:Using data from a multicenter cohort study of HIV-1-infected women and their children, the authors fit repeated measures regression models to estima...


    pub_type: 杂志文章,多中心研究


    authors: Macmillan C,Magder LS,Brouwers P,Chase C,Hittelman J,Lasky T,Malee K,Mellins CA,Velez-Borras J

    更新日期:2001-10-23 00:00:00

  • Alterations of skin glycosaminoglycans in patients with ALS.

    abstract:BACKGROUND AND OBJECTIVE:Collagen abnormalities of skin have been reported among patients with ALS. However, little is known concerning glycosaminoglycans of the skin in ALS. Our objective was to clarify morphologic and biochemical findings of skin glycosaminoglycans among patients with ALS. METHODS:We performed morph...


    pub_type: 临床试验,杂志文章


    authors: Ono S,Imai T,Aso A,Yamano T,Shimizu N,Nagao K

    更新日期:1998-08-01 00:00:00

  • Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register.

    abstract::It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations (MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to levetiracetam. Three of 117 exposed pregnancies had an MC...


    pub_type: 杂志文章


    authors: Hunt S,Craig J,Russell A,Guthrie E,Parsons L,Robertson I,Waddell R,Irwin B,Morrison PJ,Morrow J

    更新日期:2006-11-28 00:00:00

  • Migraine and reduced work performance: a population-based diary study.

    abstract:OBJECTIVE:This article estimates lost work days and lost work day equivalents in a population sample of migraineurs, differentiating work loss due to headache episodes that met criteria for migraine from migrainous headaches not meeting full criteria and nonmigrainous headaches. METHODS:A random digit dialing survey o...


    pub_type: 杂志文章


    authors: Von Korff M,Stewart WF,Simon DJ,Lipton RB

    更新日期:1998-06-01 00:00:00

  • The childhood type of dermatomyositis.

    abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...


    pub_type: 杂志文章


    authors: Carpenter S,Karpati G,Rothman S,Watters G

    更新日期:1976-10-01 00:00:00

  • Clinical features and pathogenesis of intracerebral hemorrhage after rt-PA and heparin therapy for acute myocardial infarction: the Thrombolysis in Myocardial Infarction (TIMI) II Pilot and Randomized Clinical Trial combined experience.

    abstract::Parenchymatous intracerebral hemorrhage (ICH) is a serious, infrequent complication of thrombolytic therapy for acute myocardial infarction. We studied the clinical and radiologic features, manner of presentation, associated factors, and temporal course in 23 patients with ICH associated with 150 mg or 100 mg recombin...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sloan MA,Price TR,Petito CK,Randall AM,Solomon RE,Terrin ML,Gore J,Collen D,Kleiman N,Feit F

    更新日期:1995-04-01 00:00:00

  • APOE genotype and survival in men and women with Alzheimer's disease.

    abstract:BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...


    pub_type: 杂志文章


    authors: Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

    更新日期:2002-04-09 00:00:00

  • The neurologic complications of B-cell chronic lymphocytic leukemia.

    abstract::We performed a retrospective study to characterize the type, frequency, and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia (B-CLL). We reviewed 962 total charts with a median follow-up time of 57.5 months. There were 109 cases (11.3%) of neurologic complications, including 69 c...


    pub_type: 杂志文章


    authors: Bower JH,Hammack JE,McDonnell SK,Tefferi A

    更新日期:1997-02-01 00:00:00

  • Interferon beta-1a treatment in childhood and juvenile-onset multiple sclerosis.

    abstract::The authors studied the safety and tolerability of subcutaneous interferon beta-1a at different doses in 24 children with clinically definite multiple sclerosis. After a mean treatment period of 44 months, interferon beta-1a was well tolerated in 22 patients, although two experienced possible serious adverse events. A...


    pub_type: 杂志文章


    authors: Tenembaum SN,Segura MJ

    更新日期:2006-08-08 00:00:00

  • Right hippocampal sclerosis is more common than left after febrile seizures.

    abstract::Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...


    pub_type: 临床试验,杂志文章


    authors: Janszky J,Woermann FG,Barsi P,Schulz R,Halász P,Ebner A

    更新日期:2003-04-08 00:00:00

  • Therapy and management of frontal lobe dementia patients.

    abstract::Patients with frontal lobe dementia (FLD) include those who suffer from Pick's disease, corticobasal degeneration, FLD without specific histopathologic features, as well as the infrequent families with frontotemporal dementia and parkinsonism associated with chromosome 17. Currently there have been no systematic effor...


    pub_type: 杂志文章,评审


    authors: Litvan I

    更新日期:2001-06-01 00:00:00

  • Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies.

    abstract::Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyryl...


    pub_type: 杂志文章


    authors: Perry E,McKeith I,Ballard C

    更新日期:2003-06-10 00:00:00

  • Epilepsy and sleep apnea syndrome.

    abstract::We identified seven patients with refractory partial epilepsy and sleep apnea. Treatment of the sleep apnea with nasal continuous positive airway pressure (CPAP), protriptyline, trazodone, acetazolamide, or tracheostomy reduced seizure frequency and severity in six patients. Success with CPAP depended largely on compl...


    pub_type: 杂志文章


    authors: Devinsky O,Ehrenberg B,Barthlen GM,Abramson HS,Luciano D

    更新日期:1994-11-01 00:00:00

  • Progressive parkinsonism associated with Rosenthal fibers: senile-onset Alexander's disease?

    abstract::Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...


    pub_type: 杂志文章


    authors: Friedman JH,Ambler M

    更新日期:1992-09-01 00:00:00

  • Muscle acid protease activity in amyotrophic lateral sclerosis: correlation with clinical and pathologic features.

    abstract::Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...


    pub_type: 杂志文章


    authors: Antel JP,Chelmicka-Schorr E,Sportiello M,Stefansson K,Wollmann RL,Arnason BG

    更新日期:1982-08-01 00:00:00

  • Multisequence MRI in clinically isolated syndromes and the early development of MS.

    abstract:OBJECTIVE:To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and to determine their predictive values for the early development of clinical MS. BACKGROUND:Disseminated lesions on T2-weighted brain...


    pub_type: 杂志文章


    authors: Brex PA,O'Riordan JI,Miszkiel KA,Moseley IF,Thompson AJ,Plant GT,Miller DH

    更新日期:1999-10-12 00:00:00

  • Vertical and horizontal meridian sparing in occipital lobe homonymous hemianopias.

    abstract::We report two patients with unique homonymous hemianopias from occipital lobe infarctions. One patient had vertical meridian sparing, and the other displayed horizontal meridian sparing. MRI correlation with the visual field defects confirmed that the vertical hemianopic meridian was represented along the border of th...


    pub_type: 杂志文章


    authors: Gray LG,Galetta SL,Schatz NJ

    更新日期:1998-04-01 00:00:00

  • Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis.

    abstract:OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...


    pub_type: 杂志文章


    authors: Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

    更新日期:2017-09-26 00:00:00

  • Prospective associations between white matter hyperintensities and lower extremity function.

    abstract:OBJECTIVE:To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints. METHODS:We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and fr...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Moon SY,de Souto Barreto P,Rolland Y,Chupin M,Bouyahia A,Fillon L,Mangin JF,Andrieu S,Cesari M,Vellas B,MAPT\/DSA Study Group.

    更新日期:2018-04-10 00:00:00

  • Subcortical aphasia: the core profile of capsulostriatal infarction.

    abstract::There has been disagreement about the precise characteristics of "subcortical aphasia." We evaluated 14 patients with aphasia after subcortical lesions and controlled for duration, general anatomic site of lesions (capsulostriatal only), and etiology. The clinical profiles of the patients were quite similar, varying i...


    pub_type: 杂志文章


    authors: Mega MS,Alexander MP

    更新日期:1994-10-01 00:00:00

  • Continuous and routine EEG in intensive care: utilization and outcomes, United States 2005-2009.

    abstract:OBJECTIVES:To evaluate the effect of intensive care unit continuous EEG (cEEG) monitoring on inpatient mortality, hospital charges, and length of stay. METHODS:A retrospective cross-sectional study was conducted using the Nationwide Inpatient Sample, a dataset representing 20% of inpatient discharges in nonfederal US ...


    pub_type: 杂志文章


    authors: Ney JP,van der Goes DN,Nuwer MR,Nelson L,Eccher MA

    更新日期:2013-12-03 00:00:00

  • Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report.

    abstract::Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...


    pub_type: 杂志文章


    authors: Landau WM,Torack RM,Guggenheim MA

    更新日期:1976-09-01 00:00:00

  • Seizure-associated brain injury in term newborns with perinatal asphyxia.

    abstract:BACKGROUND:There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE:To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS:Ninety term neonates were s...


    pub_type: 杂志文章


    authors: Miller SP,Weiss J,Barnwell A,Ferriero DM,Latal-Hajnal B,Ferrer-Rogers A,Newton N,Partridge JC,Glidden DV,Vigneron DB,Barkovich AJ

    更新日期:2002-02-26 00:00:00

  • Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.

    abstract::Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection a...


    pub_type: 杂志文章,评审


    authors: Whitley RJ

    更新日期:1995-12-01 00:00:00