Abstract:
:We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age- and sex-matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first-degree relatives, family history of psychotic disorders in first-degree relatives, and left-handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.
journal_name
Neurologyjournal_title
Neurologyauthors
Li G,Shen YC,Li YT,Chen CH,Zhau YW,Silverman JMdoi
10.1212/wnl.42.8.1481subject
Has Abstractpub_date
1992-08-01 00:00:00pages
1481-8issue
8eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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