Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.


OBJECTIVE:To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. RESULTS:In 3,405 participants, 866 participants (25.4%) experienced major disability or died within 3 months. In multivariable analyses, elevated high-sensitive C-reactive protein, complement C3, matrix metalloproteinase-9, hepatocyte growth factor, and antiphosphatidylserine antibodies were individually associated with the primary outcome. Participants with a larger number of elevated biomarkers had increased risk of all study outcomes. The adjusted odds ratios (95% confidence intervals) of participants with 5 elevated biomarkers were 3.88 (2.05-7.36) for the primary outcome, 2.81 (1.49-5.33) for major disability, 5.67 (1.09-29.52) for death, and 4.00 (1.22-13.14) for vascular events, compared to those with no elevated biomarkers. Simultaneously adding these 5 biomarkers to the basic model with traditional risk factors led to substantial reclassification for the combined outcome (net reclassification improvement 28.5%, p < 0.001; integrated discrimination improvement 2.2%, p < 0.001) and vascular events (net reclassification improvement 37.0%, p = 0.001; integrated discrimination improvement 0.8%, p = 0.001). CONCLUSION:We observed a clear gradient relationship between the numbers of elevated novel biomarkers and risk of major disability, mortality, and vascular events. Incorporation of a combination of multiple biomarkers observed substantially improved the risk stratification for adverse outcomes in ischemic stroke patients.






Zhong C,Zhu Z,Wang A,Xu T,Bu X,Peng H,Yang J,Han L,Chen J,Xu T,Peng Y,Wang J,Li Q,Ju Z,Geng D,He J,Zhang Y




Has Abstract


2019-01-22 00:00:00














  • Pharmacokinetics, pharmacodynamics, and tolerability of tolcapone: a review of early studies in volunteers.

    abstract::Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...


    pub_type: 杂志文章,评审


    authors: Jorga KM

    更新日期:1998-05-01 00:00:00

  • Autonomic hyperreflexia in pure progressive autonomic failure: a case report.

    abstract::A 60-year-old woman suffered from recurrent episodes of fever, hypertension, facial flushing, vomiting, stridor, slowly progressive symptoms of hypohidrosis, and orthostatic hypotension. The episodes were synchronous with elevated catecholamine concentration in plasma and urine. This is an example of paroxysmal autono...


    pub_type: 杂志文章


    authors: Mitsui T,Kawai H,Taguchi E,Miyamoto H,Saito S

    更新日期:1993-09-01 00:00:00

  • Neurofilament light and tau as blood biomarkers for sports-related concussion.

    abstract:OBJECTIVE:To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP). METHODS:A total of 288 professional hockey players ...


    pub_type: 杂志文章


    authors: Shahim P,Tegner Y,Marklund N,Blennow K,Zetterberg H

    更新日期:2018-05-15 00:00:00

  • Lateralizing signs in intractable partial epilepsy: blinded multiple-observer analysis.

    abstract::We evaluated the accuracy and interobserver variability of selected ictal and postictal behavioral changes. Three observers, blinded to clinical history, EEG, and side of surgical resection, analyzed videotapes of 166 seizures in 38 patients, looking for lateralizing signs. Twenty-seven patients with temporal lobe res...


    pub_type: 杂志文章


    authors: Chee MW,Kotagal P,Van Ness PC,Gragg L,Murphy D,Lüders HO

    更新日期:1993-12-01 00:00:00

  • Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades.

    abstract::We investigated the activation of frontal and occipital cortical areas in 14 normal volunteers during voluntary saccades in light or dark and during imagined saccades using functional magnetic resonance imaging (FMRI) with electro-oculogram monitoring. Voluntary saccades in light or dark and imagined saccades led to a...


    pub_type: 杂志文章


    authors: Bodis-Wollner I,Bucher SF,Seelos KC,Paulus W,Reiser M,Oertel WH

    更新日期:1997-08-01 00:00:00

  • Friedreich's ataxia GAA repeat expansion in patients with recessive or sporadic ataxia.

    abstract::To explore the clinical heterogeneity associated with the Friedreich's ataxia (FRDA) expanded repeat and provide preliminary guidance for future gene testing in patients suspected of having FRDA, we tested patients with typical FRDA (group I), late-onset FRDA or FRDA with retained reflexes (group II), as well as those...


    pub_type: 杂志文章


    authors: Geschwind DH,Perlman S,Grody WW,Telatar M,Montermini L,Pandolfo M,Gatti RA

    更新日期:1997-10-01 00:00:00

  • Neural transplantation in Huntington disease: long-term grafts in two patients.

    abstract:OBJECTIVE:Clinical trials of fetal neural tissue transplantation for Huntington disease (HD) have been conducted with variable clinical results. However, no long-term analysis of graft survival and integration has been published. Here, we report the pathologic findings in two patients with HD who died 74 and 79 months ...


    pub_type: 杂志文章


    authors: Keene CD,Sonnen JA,Swanson PD,Kopyov O,Leverenz JB,Bird TD,Montine TJ

    更新日期:2007-06-12 00:00:00

  • Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

    abstract::The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occu...


    pub_type: 杂志文章


    authors: Rosas HD,Hevelone ND,Zaleta AK,Greve DN,Salat DH,Fischl B

    更新日期:2005-09-13 00:00:00

  • Forced collectionism after orbitofrontal damage.

    abstract::A collector is a person who collects things on purpose, either as a hobby or business, or for personal satisfaction, e.g., stamp, coin, or art collector. In such instances, the act of collecting things represents voluntary, controlled, goal-directed, selective searching. Pathologic patterns of collecting have been obs...


    pub_type: 杂志文章


    authors: Volle E,Beato R,Levy R,Dubois B

    更新日期:2002-02-12 00:00:00

  • Oculopharyngodistal myopathy is a distinct entity: clinical and genetic features of 47 patients.

    abstract:BACKGROUND:Oculopharyngodistal myopathy (OPDM) has been reported as a rare, adult-onset hereditary muscle disease with putative autosomal dominant and autosomal recessive inheritance. Patients with OPDM present with progressive ocular, pharyngeal, and distal limb muscle involvement. The genetic defect causing OPDM has ...


    pub_type: 杂志文章


    authors: Durmus H,Laval SH,Deymeer F,Parman Y,Kiyan E,Gokyigiti M,Ertekin C,Ercan I,Solakoglu S,Karcagi V,Straub V,Bushby K,Lochmüller H,Serdaroglu-Oflazer P

    更新日期:2011-01-18 00:00:00

  • Cerebral microbleeds are regionally associated with intracerebral hemorrhage.

    abstract:BACKGROUND:Cerebral microbleeds (CMB) may be indicative of a hemorrhage-prone microangiopathy. OBJECTIVE:To determine if increased numbers of these lesions are predictive of intracerebral hemorrhage (ICH), especially in terms of a distributional association. METHODS:The authors examined consecutively 227 patients wit...


    pub_type: 杂志文章


    authors: Lee SH,Bae HJ,Kwon SJ,Kim H,Kim YH,Yoon BW,Roh JK

    更新日期:2004-01-13 00:00:00

  • Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.

    abstract::Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotyp...


    pub_type: 杂志文章


    authors: Badrising UA,Schreuder GM,Giphart MJ,Geleijns K,Verschuuren JJ,Wintzen AR,Maat-Schieman ML,van Doorn P,van Engelen BG,Faber CG,Hoogendijk JE,de Jager AE,Koehler PJ,de Visser M,van Duinen SG,Dutch IBM Study Group.

    更新日期:2004-12-28 00:00:00

  • Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease.

    abstract:BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...


    pub_type: 杂志文章


    authors: Hashimoto M,Yasuda M,Tanimukai S,Matsui M,Hirono N,Kazui H,Mori E

    更新日期:2001-10-23 00:00:00

  • Root stimulation studies in the evaluation of patients with motor neuron disease.

    abstract::Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...


    pub_type: 杂志文章


    authors: Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA

    更新日期:1998-06-01 00:00:00

  • Fat metabolism during exercise in patients with McArdle disease.

    abstract:OBJECTIVE:It is known that muscle phosphorylase deficiency restricts carbohydrate utilization, but the implications for muscle fat metabolism have not been studied. We questioned whether patients with McArdle disease can compensate for the blocked muscle glycogen breakdown by enhancing fat oxidation during exercise. M...


    pub_type: 杂志文章


    authors: Ørngreen MC,Jeppesen TD,Andersen ST,Taivassalo T,Hauerslev S,Preisler N,Haller RG,van Hall G,Vissing J

    更新日期:2009-02-24 00:00:00

  • Apolipoprotein E genotype and memory in the sixth decade of life.

    abstract:BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging an...


    pub_type: 杂志文章


    authors: Schultz MR,Lyons MJ,Franz CE,Grant MD,Boake C,Jacobson KC,Xian H,Schellenberg GD,Eisen SA,Kremen WS

    更新日期:2008-05-06 00:00:00

  • Expanding the clinical spectrum of POMT1 phenotype.

    abstract::Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular m...


    pub_type: 杂志文章


    authors: D'Amico A,Tessa A,Bruno C,Petrini S,Biancheri R,Pane M,Pedemonte M,Ricci E,Falace A,Rossi A,Mercuri E,Santorelli FM,Bertini E

    更新日期:2006-05-23 00:00:00

  • Dementia in Down's syndrome: cerebral glucose utilization, neuropsychological assessment, and neuropathology.

    abstract::We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down's syndrome (DS) and autopsy-confirmed Alzheimer's disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and pe...


    pub_type: 杂志文章


    authors: Schapiro MB,Ball MJ,Grady CL,Haxby JV,Kaye JA,Rapoport SI

    更新日期:1988-06-01 00:00:00

  • Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus.

    abstract::Traditional side-by-side visual interpretation of ictal and interictal single-photon emission computed tomography (SPECT) scans can be difficult in identifying the surgical focus, particularly in patients with extratemporal or otherwise unlocalized intractable epilepsy. Computer-aided subtraction ictal SPECT co-regist...


    pub_type: 杂志文章


    authors: O'Brien TJ,So EL,Mullan BP,Hauser MF,Brinkmann BH,Bohnen NI,Hanson D,Cascino GD,Jack CR Jr,Sharbrough FW

    更新日期:1998-02-01 00:00:00

  • Deep gray matter involvement in neurobrucellosis.

    abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...


    pub_type: 杂志文章


    authors: Rajan R,Khurana D,Kesav P

    更新日期:2013-01-15 00:00:00

  • Multifocal central nervous system damage caused by toluene abuse.

    abstract::Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter...


    pub_type: 杂志文章


    authors: Lazar RB,Ho SU,Melen O,Daghestani AN

    更新日期:1983-10-01 00:00:00

  • Why do frontal lobe symptoms predominate in vascular dementia with lacunes?

    abstract::We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...


    pub_type: 杂志文章


    authors: Ishii N,Nishihara Y,Imamura T

    更新日期:1986-03-01 00:00:00

  • Seizures and their outcome in progressive multifocal leukoencephalopathy.

    abstract::Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival...


    pub_type: 杂志文章


    authors: Lima MA,Drislane FW,Koralnik IJ

    更新日期:2006-01-24 00:00:00

  • A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy.

    abstract:OBJECTIVES:Laminin alpha2 deficiency presents at birth with muscle weakness, hypotonia, and usually asymptomatic white matter signal on MRI. Few patients with laminin alpha2 deficiency have been described with seizures and structural brain abnormalities. The reason for the variation in the severity of the clinical phen...


    pub_type: 杂志文章


    authors: Pegoraro E,Fanin M,Trevisan CP,Angelini C,Hoffman EP

    更新日期:2000-10-24 00:00:00

  • Validating and comparing stroke prognosis scales.

    abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...


    pub_type: 杂志文章


    authors: Quinn TJ,Singh S,Lees KR,Bath PM,Myint PK,VISTA Collaborators.

    更新日期:2017-09-05 00:00:00

  • HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States.

    abstract::HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in the Caribbean basin and Japan. Because of the close proximity of the United States to the Caribbean and the presence of HTLV-I-seropositive persons in the United States, we sought reports of patients who were HTLV-I seropositive and had ...


    pub_type: 杂志文章


    authors: Janssen RS,Kaplan JE,Khabbaz RF,Hammond R,Lechtenberg R,Lairmore M,Chiasson MA,Punsalang A,Roberts B,McKendall RR

    更新日期:1991-09-01 00:00:00

  • Decreased striatal monoaminergic terminals in Huntington disease.

    abstract:OBJECTIVE:To evaluate the integrity of the dorsal striatal dopaminergic innervation in rigid and choreic Huntington disease (HD). BACKGROUND:Some patients with HD have an akinetic-rigid phenotype. It has been suggested that nigrostriatal in addition to striatal pathology is present in this subgroup. The authors sought...


    pub_type: 杂志文章


    authors: Bohnen NI,Koeppe RA,Meyer P,Ficaro E,Wernette K,Kilbourn MR,Kuhl DE,Frey KA,Albin RL

    更新日期:2000-05-09 00:00:00

  • Leptomeningeal metastases: analysis of 31 patients with sustained off-therapy response following combined-modality therapy.

    abstract::Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months' duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44 (29%); breast carcinoma, 10/51 (20%); a...


    pub_type: 杂志文章


    authors: Siegal T,Lossos A,Pfeffer MR

    更新日期:1994-08-01 00:00:00

  • Basilar migraine, seizures, and severe epileptiform EEG abnormalities.

    abstract::Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...


    pub_type: 杂志文章


    authors: Camfield PR,Metrakos K,Andermann F

    更新日期:1978-06-01 00:00:00

  • Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy.

    abstract::Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is incre...


    pub_type: 杂志文章


    authors: Fujioka S,Algom AA,Murray ME,Strongosky A,Soto-Ortolaza AI,Rademakers R,Ross OA,Wszolek ZK,Dickson DW

    更新日期:2013-05-28 00:00:00