Abstract:
:Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarbital concentrations below 20 mg per liter, 7 neonates required levels above 30 mg per liter. We recommend that plasma phenobarbital concentrations should equal or surpass 40 mg per liter before additional anticonvulsants are used for neonates with seizures.
journal_name
Neurologyjournal_title
Neurologyauthors
Gal P,Toback J,Boer HR,Erkan NV,Wells TJdoi
10.1212/wnl.32.12.1401subject
Has Abstractpub_date
1982-12-01 00:00:00pages
1401-4issue
12eissn
0028-3878issn
1526-632Xjournal_volume
32pub_type
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