Applying the ATN scheme in a memory clinic population: The ABIDE project.

abstract：OBJECTIVES:To estimate patient-acceptable symptom state (PASS) cut points for myasthenia gravis (MG) health scales. METHODS:We conducted an electronic survey that included the Myasthenia Gravis Impairment Index (MGII), EuroQol 5-Dimension (EQ5D), and a simple PASS question. PASS-anchored thresholds were estimated for ...

journal_title：Neurology

authors： Mendoza M,Tran C,Bril V,Katzberg HD,Barnett C

更新日期：2020-09-22 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：:The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...

journal_title：Neurology

authors： Dodson WE

更新日期：1980-02-01 00:00:00

abstract：:An 18-year-old man had noticed increasing difficulty in walking for 4 years. Examination disclosed spastic paraparesis and posterior column signs suggestive of subacute combined degeneration of the spinal cord. Urinalysis, urinary thin-layer chromatography, and intestinal biopsy disclosed typical cystinuria. Perniciou...

journal_title：Neurology

authors： De Myer W,Gebhard RL

更新日期：1975-10-01 00:00:00

abstract：:We developed a method for the detection of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) carriers. The method is based on the quantitative analysis of the products of standard multiplex polymerase chain reaction (PCR) from 18 different exons of the dystrophin gene, and is designated "QM-PCR." W...

journal_title：Neurology

authors： Ioannou P,Christopoulos G,Panayides K,Kleanthous M,Middleton L

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...

journal_title：Neurology

authors： Qubty W,Patniyot I,Gelfand A

更新日期：2018-05-08 00:00:00

abstract：OBJECTIVE:To determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal individuals older than 60 years. METHODS:Participants (n = 154; mean ag...

journal_title：Neurology

authors： Han JW,Maillard P,Harvey D,Fletcher E,Martinez O,Johnson DK,Olichney JM,Farias ST,Villeneuve S,Jagust W,Mungas D,DeCarli C

更新日期：2020-11-10 00:00:00

abstract：:Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron m...

journal_title：Neurology

authors： Mathis S,Le Masson G,Vallat JM

更新日期：2019-10-29 00:00:00

abstract：OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...

journal_title：Neurology

authors： Kent DM,Ruthazer R,Decker C,Jones PG,Saver JL,Bluhmki E,Spertus JA

更新日期：2015-09-15 00:00:00

abstract：OBJECTIVE:To determine if abnormalities exist in postural control in autism and if they are related to age. METHODS:Dynamic posturography was performed in 79 autistic individuals without mental retardation and 61 healthy volunteers between ages 5 and 52 years. Both the sensory organization and the movement coordinatio...

journal_title：Neurology

authors： Minshew NJ,Sung K,Jones BL,Furman JM

更新日期：2004-12-14 00:00:00

abstract：:Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...

journal_title：Neurology

authors： Futrell N,Schultz LR,Millikan C

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...

journal_title：Neurology

authors： Silberstein S,Tepper S,Brandes J,Diamond M,Goldstein J,Winner P,Venkatraman S,Vrijens F,Malbecq W,Lines C,Visser WH,Reines S,Yuen E

更新日期：2004-05-11 00:00:00

abstract：:Six neonates with prolonged, intractable seizures were treated with valproic acid (VPA). Each patient had received maximum doses of phenobarbital (greater than 40 micrograms/ml), and five patients received at least two additional anticonvulsants, without success. Seizure activity was controlled in five of six (83%) ca...

journal_title：Neurology

authors： Gal P,Oles KS,Gilman JT,Weaver R

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:To characterize the nature and degree of cognitive morbidity in patients with chronic temporal lobe epilepsy compared with healthy control subjects, determine the association between the duration of epilepsy and cognitive morbidity, and ascertain whether there are factors that moderate the association between...

journal_title：Neurology

authors： Oyegbile TO,Dow C,Jones J,Bell B,Rutecki P,Sheth R,Seidenberg M,Hermann BP

更新日期：2004-05-25 00:00:00

abstract：:Coma is rare in temporal arteritis (TA). We describe a patient with TA who suddenly developed coma with a triphasic EEG pattern that resolved after initiation of steroid treatment. Although the arterial lesions in TA are segmental in nature, TA may present with signs of diffuse neurologic deficit; early treatment can ...

journal_title：Neurology

authors： Tomer Y,Neufeld MY,Shoenfeld Y

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:To investigate the genotype-phenotype correlation between neurofibromatosis 1 (NF1) germline mutations and imaging features of neurofibromas on whole-body MRI (WBMRI) by using radiomics image analysis techniques. MATERIALS AND METHODS:Twenty-nine patients with NF1 who had known germline mutations determined ...

journal_title：Neurology

authors： Liu Y,Jordan JT,Bredella MA,Erdin S,Walker JA,Vangel M,Harris GJ,Plotkin SR,Cai W

更新日期：2020-06-16 00:00:00

abstract：OBJECTIVE:To investigate the long-term outcome of patients with spinal cord infarct (SCI) and identify prognostic predictors. METHODS:We reviewed 115 patients with SCI treated between 1990 and 2007. Severity of impairment was defined using the American Spinal Injury Association (ASIA) scoring. Functional outcome endpo...

journal_title：Neurology

authors： Robertson CE,Brown RD Jr,Wijdicks EF,Rabinstein AA

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T and B cells into the CNS. The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of acti...

journal_title：Neurology

authors： Kivisäkk P,Healy BC,Viglietta V,Quintana FJ,Hootstein MA,Weiner HL,Khoury SJ

更新日期：2009-06-02 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study. METHODS:A novel ex vivo assay was developed to identify pesticides that can inhibi...

journal_title：Neurology

authors： Fitzmaurice AG,Rhodes SL,Cockburn M,Ritz B,Bronstein JM

更新日期：2014-02-04 00:00:00

abstract：:The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...

journal_title：Neurology

authors： Binder JR

更新日期：2015-12-15 00:00:00

abstract：:Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...

journal_title：Neurology

authors： Mollman JE,Cardenas JC,Pleasure DE

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:To use the Unified Batten Disease Rating Scale (UBDRS) to measure the rate of decline in physical and functional capability domains in patients with juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease, a neurodegenerative lysosomal storage disorder. We have evaluated the UBDRS in subjects with JN...

journal_title：Neurology

authors： Kwon JM,Adams H,Rothberg PG,Augustine EF,Marshall FJ,Deblieck EA,Vierhile A,Beck CA,Newhouse NJ,Cialone J,Levy E,Ramirez-Montealegre D,Dure LS,Rose KR,Mink JW

更新日期：2011-11-15 00:00:00

abstract：:Human subjects normally have miniature eye movements during tasks that require steady visual fixation. These eye movements were compared in 12 control subjects and 4 patients with degenerative cerebellar disorders. Slow drifts, small fixation saccades, square waves, saccadic oscillations, flutter, and vertical nystagm...

journal_title：Neurology

authors： Hotson JR

更新日期：1982-01-01 00:00:00

abstract：:In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...

journal_title：Neurology

authors： Niemeier M,Karnath HO

更新日期：2000-01-25 00:00:00

abstract：:Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders will be treated by physicians and primary care providers witho...

journal_title：Neurology

authors： Sandrone S,Berthaud JV,Chuquilin M,Cios J,Ghosh P,Gottlieb-Smith RJ,Kushlaf H,Mantri S,Masangkay N,Menkes DL,Nevel KS,Sarva H,Schneider LD

更新日期：2019-01-22 00:00:00

abstract：OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...

journal_title：Neurology

authors： Josephs KA,Duffy JR,Strand EA,Machulda MM,Senjem ML,Lowe VJ,Jack CR Jr,Whitwell JL

更新日期：2013-07-23 00:00:00

abstract：:Mitochondrial and cytoplasmic malic isoenzymes were assayed fluorometrically in digitonin-fractionated fibroblasts from three patients with Friedreich's ataxia (FA). Normal activity was found, failing to verify an earlier report of reduced fibroblast mitochondrial malic enzyme activity in FA. The previously reported d...

journal_title：Neurology

authors： Fernandez RJ,Civantos F,Tress E,Maltese WA,De Vivo DC

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:Structural and functional lesion localization in patients with hemispatial neglect. DESIGN:Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. PATIENTS:Participants include...

journal_title：Neurology

authors： Leibovitch FS,Black SE,Caldwell CB,Ebert PL,Ehrlich LE,Szalai JP

更新日期：1998-04-01 00:00:00

abstract：:Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...

journal_title：Neurology

authors： Guttman M

更新日期：1997-10-01 00:00:00

abstract：:Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...

journal_title：Neurology

authors： Devinsky O,Asato M,Camfield P,Geller E,Kanner AM,Keller S,Kerr M,Kossoff EH,Lau H,Kothare S,Singh BK,Wirrell E

更新日期：2015-10-27 00:00:00