Abstract:
OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic stroke between 1996 and 2016 were identified through Danish nationwide registries. We calculated annual age-standardized incidence rates and absolute 30-day and 1-year mortality risks. Furthermore, we calculated annual incidence rate ratios using Poisson regression, odds ratios for 30-day mortality using logistic regression, and hazard ratios for 1-year mortality using Cox regression. RESULTS:The overall age-standardized incidence rates of ischemic stroke per 1,000 person-years increased from 1996 (2.70 [95% confidence interval [CI] 2.65-2.76]) to 2002 (3.25 [95% CI 3.20-3.31]) and then gradually decreased to below the initial level until 2016 (1.99 [95% CI 1.95-2.02]). Men had higher incidence rates than women in all age groups except 18 to 34 and ≥85 years. Absolute mortality risk decreased between 1996 and 2016 (30-day mortality from 17.1% to 7.6% and 1-year mortality from 30.9% to 17.3%). Women between 55 and 64 and ≥85 years of age had higher mortality than men. Similar trends were observed for all analyses after multivariable adjustment. The prevalence of atrial fibrillation, hypertension, diabetes mellitus, and use of lipid-lowering medication increased during the study period. CONCLUSIONS:The age-standardized incidence of first-time hospitalization for ischemic stroke increased from 1996 to 2002 and then gradually decreased to below the initial level until 2016. Absolute 30-day and 1-year mortality risks decreased between 1996 and 2016. These findings correspond to increased stroke prevention awareness and introduction of new treatments during the study period.
journal_name
Neurologyjournal_title
Neurologyauthors
Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JHdoi
10.1212/WNL.0000000000010647subject
Has Abstractpub_date
2020-10-27 00:00:00pages
e2343-e2353issue
17eissn
0028-3878issn
1526-632Xpii
WNL.0000000000010647journal_volume
95pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318245f476
更新日期:2012-02-07 00:00:00
abstract:OBJECTIVES:To further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS). METHODS:We compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled). RESULT...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006367
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310644.40767.aa
更新日期:2008-04-22 00:00:00
abstract:OBJECTIVE:To identify modifying factors that preserve functional independence among individuals at high dementia risk. METHODS:Health and Retirement Study participants aged 65 years or older without baseline activities of daily living (ADL) limitations (n = 4,922) were interviewed biennially for up to 12 years. Dement...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000357
更新日期:2014-04-29 00:00:00
abstract::Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.831
更新日期:1984-06-01 00:00:00
abstract:OBJECTIVE:To learn to which portions of a line normal subjects would attend when watching this line actually moving or when perceiving movement even in the absence of actual movement, an illusory movement. METHODS:Twenty normal subjects watched a computer monitor on which either lines or dots moved to the right or lef...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000120546.14213.c7
更新日期:2004-04-27 00:00:00
abstract::Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.11.2150
更新日期:2000-06-13 00:00:00
abstract::Age at 1st risk for seizures may predict anomia following dominant anterior temporal lobectomy. We assessed confrontation naming before and 2 to 3 weeks after surgery in 45 right-handed patients grouped by side of focus and presence or absence of early (less than or equal to 5 years) risk factors. After left lobectomy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.10.1509
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task. BACKGROUND:Functional imaging studies comparing task-related activation in AD patients and controls generally have not used network analysis and have not controlled for task diff...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.9.1291
更新日期:2000-11-14 00:00:00
abstract::A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodgkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a bead...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.6.588
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142988.49341.d1
更新日期:2004-11-09 00:00:00
abstract:OBJECTIVE:To report the CNS syndromes of patients ≥60 years of age with antibodies against neuronal surface antigens but no evidence of brain MRI and CSF inflammatory changes. METHODS:This was a retrospective clinical analysis of patients with antibodies against neuronal surface antigens who fulfilled 3 criteria: age ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004541
更新日期:2017-10-03 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002525
更新日期:2016-03-29 00:00:00
abstract::Two patients with acute onset of profound weakness and loss of muscle bulk during a critical illness had unusual histopathological changes of type II myofibers. Both patients had respiratory failure and prolonged neuromuscular blockade. High-dose steroids were used in only one case and atracurium in the other. Muscle ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.3.819
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000174439.70369.7a
更新日期:2005-09-13 00:00:00
abstract:OBJECTIVE:To examine the genetic relationships among epilepsies with different seizure types--myoclonic, absence, and generalized tonic-clonic--within the idiopathic generalized epilepsies (IGEs). BACKGROUND:Careful phenotype definition in the epilepsies may allow division into groups that share susceptibility genes. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000172920.34994.63
更新日期:2005-08-23 00:00:00
abstract:BACKGROUND:There is a paucity of therapies for gait impairment in Parkinson disease (PD). Open-label studies have suggested improved gait after treatment with methylphenidate (MPD). OBJECTIVE:To evaluate the efficacy of MPD for the treatment of gait impairment in PD. METHODS:Twenty-seven subjects with PD and moderate...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3182143537
更新日期:2011-04-05 00:00:00
abstract::Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for eac...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.4.400
更新日期:1983-04-01 00:00:00
abstract:OBJECTIVE:Analysis of twins with epilepsy to explore the genetic architecture of specific epilepsies, to evaluate the applicability of the 2010 International League Against Epilepsy (ILAE) organization of epilepsy syndromes, and to integrate molecular genetics with phenotypic analyses. METHODS:A total of 558 twin pair...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000790
更新日期:2014-09-16 00:00:00
abstract:OBJECTIVE:To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS:We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 year...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005814
更新日期:2018-07-17 00:00:00
abstract:BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345969.57574.f5
更新日期:2009-05-19 00:00:00
abstract:BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327643.05073.eb
更新日期:2008-10-14 00:00:00
abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827deb63
更新日期:2013-01-15 00:00:00
abstract::Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Fi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.11.1733
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society develop practice parameters as strategies for patient management based on analysis of evidence. For this parameter, the authors reviewed available evidence on the evaluation of the...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引
doi:10.1212/wnl.59.4.490
更新日期:2002-08-27 00:00:00
abstract:OBJECTIVE:To evaluate attention deficit in Alzheimer's disease (AD) and its relationship to attention deficits associated with aging and with medications altering alertness. METHODS:Ten patients with probable AD, 10 healthy old controls, and 15 young controls performed a covert orienting of spatial attention task. You...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.657
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1094
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000141144.02666.8c
更新日期:2004-10-12 00:00:00
abstract::Hepatitis C virus (HCV) infection may be associated with neurocognitive deficits. The Hemophilia Growth and Development Study enrolled HIV-infected and HIV-uninfected patients and a group of nonhemophiliac siblings. After controlling for multiple factors, HCV monoinfection was not associated with deficits in adaptive ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000240255.42608.99
更新日期:2006-10-24 00:00:00
abstract::A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.329
更新日期:1988-02-01 00:00:00