Abstract:
:Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for each patient studied. Focal and generalized increased and decreased metabolism were observed. Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields. Hypometabolism seen on ictal scans most likely reflects postictal depression and may indicate projection fields of inhibited neurons. No quantitative relationship between alterations in metabolism and EEG or behavioral measurements of ictal events could be demonstrated.
journal_name
Neurologyjournal_title
Neurologyauthors
Engel J Jr,Kuhl DE,Phelps ME,Rausch R,Nuwer Mdoi
10.1212/wnl.33.4.400subject
Has Abstractpub_date
1983-04-01 00:00:00pages
400-13issue
4eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001211
更新日期:2015-02-03 00:00:00
abstract::We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.2.412
更新日期:1993-02-01 00:00:00
abstract::We studied the effect of a single oral intake of 30 to 40 grams of alcohol in 4 consecutive patients presenting with Ramsay Hunt syndrome, the most common type of degenerative progressive myoclonic epilepsy (PME) encountered in southern Europe. Clinical and polygraphic monitoring demonstrated abatement of myoclonus in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.9.1412
更新日期:1990-09-01 00:00:00
abstract::Adult-onset dystonia-parkinsonism is a syndrome in search of a pathology. We therefore reviewed the literature on dystonic manifestations in autopsy-proven cases of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and idiopathic Parkinson's disease (PD). Only 6 of 140 autopsy reports of MSA remarke...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.40.10.1571
更新日期:1990-10-01 00:00:00
abstract::A 53-year-old man presented with multiple right cranial nerve palsies that included the tongue. When the tongue was protruded, it deviated to the right. However, when the tongue was not protruded, he could readily turn the tip of the tongue to the left, but not to the right. Protrusion of the tongue requires the actio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.10.1367
更新日期:1984-10-01 00:00:00
abstract::A 52-year-old steelworker displayed a consistent defect in leftward voluntary gaze across the midline. Both fast (saccadic) and slow (pursuit) eye movements were affected. Neuro-ophthalmologic evaluation revealed no additional neurologic or ophthalmologic deficit. Pupilary miosis occurred during leftward gaze attempt,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.82
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies. METHODS:In a randomized, double-blind study, patients with HIV-associated distal sensory polyneuropathy (DSP) received LTG or placebo during a 7-week dose escalation phase followed...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000063304.88470.d9
更新日期:2003-05-13 00:00:00
abstract::Minor head trauma precipitated oculomotor nerve palsies in two patients who subsequently were discovered to have ipsilateral posterior communicating artery aneurysms. A history of minor trauma should not dissuade investigation for underlying causes of oculomotor nerve palsy, including intracranial aneurysm. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.1.148
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether the correlation of age and sex with the risk of recurrence and death seen in patients with previous ischemic stroke is also evident in patients with embolic stroke of undetermined source (ESUS). METHODS:We pooled datasets of 11 stroke registries from Europe and America. ESUS was define...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004199
更新日期:2017-08-08 00:00:00
abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011149
更新日期:2020-11-18 00:00:00
abstract:BACKGROUND:Previously, hyperoxia and blood volume increase were reported in the red nucleus and substantia nigra during spontaneous migraine with aura. OBJECTIVE:To further understand the pathophysiologic role of these centers, activation of brainstem structures was investigated in patients with visually triggered mig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.1.72
更新日期:2002-07-09 00:00:00
abstract:OBJECTIVE:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AE...
journal_title:Neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1212/WNL.0b013e3181a6b325
更新日期:2009-07-14 00:00:00
abstract:OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of glo...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e31826c197f
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:We performed propensity score (PS) models to compare the outcome of patients with myasthenia gravis (MG) submitted to 2 different surgical approaches: extended transsternal (T-3b) or thoracoscopic extended thymectomy (VATET). METHODS:Patients' clinical data were retrieved from the MG database of the C. Besta...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004082
更新日期:2017-07-11 00:00:00
abstract::The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000208442.07548.71
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:According to the International Classification of Headache Disorders (ICHD)-2, primary daily headaches unremitting from onset are classified as new daily-persistent headache (NDPH) only if migraine features are absent. When migraine features are present, classification is problematic. METHODS:We developed a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dad5de
更新日期:2010-04-27 00:00:00
abstract:BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310644.40767.aa
更新日期:2008-04-22 00:00:00
abstract::An infant with transient neonatal myasthenia gravis had a double-blood-volume exchange transfusion because of maternal-fetal blood group incompatibility. This seemed to accelerate both decline in antiacetylcholine antibody titer and clinical improvement. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.7.911
更新日期:1981-07-01 00:00:00
abstract::The authors studied the safety and tolerability of subcutaneous interferon beta-1a at different doses in 24 children with clinically definite multiple sclerosis. After a mean treatment period of 44 months, interferon beta-1a was well tolerated in 22 patients, although two experienced possible serious adverse events. A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000231137.24467.aa
更新日期:2006-08-08 00:00:00
abstract:BACKGROUND:The Vietnam Head Injury Study (VHIS) is a prospective, longitudinal follow-up of 1,221 Vietnam War veterans with mostly penetrating head injuries (PHIs). The high prevalence (45%-53%) of posttraumatic epilepsy (PTE) in this unique cohort makes it valuable for study. METHODS:A standardized multidisciplinary ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e8e6d0
更新日期:2010-07-20 00:00:00
abstract:OBJECTIVE:The purpose of this cross-sectional study was to determine the prevalence and potential significance of stroke symptoms among end-stage renal disease (ESRD) patients without a prior diagnosis of stroke or TIA. METHODS:We enrolled 148 participants with ESRD from 5 clinics. Stroke symptoms and functional statu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826845e9
更新日期:2012-09-04 00:00:00
abstract::Restless legs syndrome (RLS) is a common neurologic disorder whose prevalence has been estimated at 4 to 10% of the general population. Although its pathophysiology remains unknown, dopaminergic mechanisms are believed to play a central role. Furthermore, dopaminergic drugs have shown therapeutic efficacy in various l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.61.6_suppl_3.s49
更新日期:2003-09-23 00:00:00
abstract:BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.8.1461
更新日期:2001-10-23 00:00:00
abstract:OBJECTIVE:To demonstrate noninvasive localization of cognitive cortical areas involved in language processing with magnetoencephalography (MEG) interpreted by multiresolution FOCUSS (MR-FOCUSS), a current density imaging technique. METHOD:MEG data were collected during verb-generation and picture-naming tasks from 18 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000130385.21160.7a
更新日期:2004-06-22 00:00:00
abstract::The prevalence of spontaneous lingual-facial-buccal movements was determined in 661 patients between the ages of 50 and 79 without neuroleptic exposure or known CNS disease. The prevalence was 0.8% between ages 50 and 59, 6% between ages 60 and 69, and 7.8% between ages 70 and 79. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.5.558
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:To determine with greater precision the map location of the locus associated with familial cavernous hemangiomas. BACKGROUND:Cavernous malformations of the brain are a significant cause of seizures, progressive or apoplectic neurologic deficit, and headache. Prevalence estimates from autopsy series vary from...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.3.752
更新日期:1997-03-01 00:00:00
abstract::The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infar...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.58.1.133
更新日期:2002-01-08 00:00:00
abstract::We performed proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with motor neuron disease (MND) to evaluate the distribution and extent of cortical neuron damage or loss as reflected by decreased N-acetyl (NA) to creatine (Cr) resonance intensity ratios. We examined premotor (superior frontal gyrus)...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.44.10.1933
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures. METHODS:This was a multicenter,...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3182635735
更新日期:2012-08-07 00:00:00
abstract::Although neurophysiologic doctrine has traditionally referred to "the" voltage-gated sodium channel, it is now clear that there are at least nine genes that encode molecularly and physiologically distinct sodium channels. Mutations of sodium channel genes provide a basis for genetic channelopathies. Dysregulated expre...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.12.1621
更新日期:2001-06-26 00:00:00