Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy.

Abstract:

:The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

journal_name

Neurology

journal_title

Neurology

authors

Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

doi

10.1212/01.wnl.0000208442.07548.71

subject

Has Abstract

pub_date

2006-04-25 00:00:00

pages

1264-6

issue

8

eissn

0028-3878

issn

1526-632X

pii

66/8/1264

journal_volume

66

pub_type

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