Abstract:
:The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
journal_name
Neurologyjournal_title
Neurologyauthors
Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli Bdoi
10.1212/01.wnl.0000208442.07548.71subject
Has Abstractpub_date
2006-04-25 00:00:00pages
1264-6issue
8eissn
0028-3878issn
1526-632Xpii
66/8/1264journal_volume
66pub_type
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