Abstract:
:Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to date, and this exercise will clarify why the contribution by McMillan et al.(1) in the current issue of Neurology is exciting and novel.
journal_name
Neurologyjournal_title
Neurologyauthors
Habeck C,Whitwell JLdoi
10.1212/WNL.0b013e31827b9305subject
Has Abstractpub_date
2013-01-08 00:00:00pages
126-7issue
2eissn
0028-3878issn
1526-632Xpii
WNL.0b013e31827b9305journal_volume
80pub_type
评论,社论相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010617
更新日期:2020-09-29 00:00:00
abstract::When multiple sclerosis (MS) presents late in life (after the age of 50), it frequently gives diagnostic difficulty. In a large MS clinic population (N = 838), 9.4% of the patients had late onset of MS. Slow deterioration of motor function characterized the initial symptoms and subsequent course of this group of older...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.12.1537
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS:A ...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000123695.22623.32
更新日期:2004-04-27 00:00:00
abstract:OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003565
更新日期:2017-01-31 00:00:00
abstract::We performed brain MRIs on 21 patients with CNS sarcoidosis. Brain CTs were performed in 18 of these. Parenchymal lesions were seen in 17 of 21 with MRI, compared with 9 of 18 with CT. MRI detected a greater number of parenchymal lesions in cases where both CT and MRI were positive, and some lesions appeared more exte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.378
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. METHODS:As proof of principle, 22 patients with well-compensated, biopsy-proven cirrhosis of differing etiology and previous minimal hepat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828726e1
更新日期:2013-03-12 00:00:00
abstract::The urinary excretion of some important phenylethylamines, catecholamines, their metabolites, amphetamine, and methamphetamine were measured in parkinsonian patients on Sinemet (L-dopa plus carbidopa, a peripheral dopadecarboxylase inhibitor) and depressed patients after chronic (-) deprenyl treatment. Deprenyl was ef...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.5.503
更新日期:1982-05-01 00:00:00
abstract::Ocular motor performance was significantly impaired in familial ataxia patients as compared with normal controls. Ataxic patients showed prolonged saccadic latencies, longer saccadic refixation times, reduced visual tracking performance, and increased hypermetria. Cutoff values were derived and applied to 15 subjects ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.4.698
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described, underrecognized neurodegenerative disorder of aging fragile X mental retardation 1 (FMR1) premutation carriers, particularly men. Core motor features are action tremor, gait ataxia, and parkinsonism. Carriers have expanded CGG repea...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000281692.98200.f5
更新日期:2008-04-15 00:00:00
abstract::A new generation of Atraumatic (blunt tipped) needles now exists in addition to the traditional Quincke (cutting tip) needles for LP. We wished to identify the optimal size and type of needle that should be used for this technique. Requirements include rapid and accurate transduction of CSF pressure and adequate flow ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.33
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c1e44f
更新日期:2009-11-17 00:00:00
abstract:OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826d5fc3
更新日期:2012-10-02 00:00:00
abstract::Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.6.584
更新日期:1978-06-01 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract::This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.59.6.950
更新日期:2002-09-24 00:00:00
abstract::The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relativ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000172340.56307.5e
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000255943.10045.c0
更新日期:2007-02-27 00:00:00
abstract:BACKGROUND:There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE:To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS:Ninety term neonates were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.4.542
更新日期:2002-02-26 00:00:00
abstract::The authors used PET to show that the abnormal pattern of cerebral blood flow (CBF) activation described in PD is normalized by electrical stimulation of subthalamic nucleus. Improvement in bradykinesia correlated with increase in CBF due to stimulation in the supplementary motor area and anterior cingulate cortex. Co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000052691.48076.92
更新日期:2003-03-25 00:00:00
abstract:OBJECTIVES:Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels to stroke severity has not been quantified. MRI measurements of lesion volume provide an objective method for stroke severity assessment and outcome pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318200d741
更新日期:2010-12-07 00:00:00
abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.550
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS:The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.9.1350
更新日期:2000-11-14 00:00:00
abstract::Dopa-responsive dystonia (DRD) is an autosomal dominant disorder typically presenting as dystonia with diurnal variability. Described is an 8-year-old boy who had had waddling gait, generalized hypotonia, and proximal weakness since early childhood. He responded well to low-dose L-dopa. He had a point mutation of the ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.6.1121
更新日期:2001-09-25 00:00:00
abstract::We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.538
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVE:To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). METHODS:Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. After a 1-week washout they crossed over to the...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.59.10.1573
更新日期:2002-11-26 00:00:00
abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.19
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004425
更新日期:2017-09-26 00:00:00
abstract::Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1649
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004740
更新日期:2017-12-12 00:00:00
abstract::A 78-year-old woman presented with a right basal ganglia infarct 6 weeks after a left herpes zoster ophthalmicus. MR angiography showed focal segmental stenosis of the proximal segments of the anterior, middle, and posterior cerebral arteries. Varicella DNA was detected in the CSF by polymerase chain reaction (PCR). T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.569
更新日期:1996-08-01 00:00:00