Abstract:
:The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events.
journal_name
Neurologyjournal_title
Neurologyauthors
Chappell AS,Sander JW,Brodie MJ,Chadwick D,Lledo A,Zhang D,Bjerke J,Kiesler GM,Arroyo Sdoi
10.1212/wnl.58.11.1680subject
Has Abstractpub_date
2002-06-11 00:00:00pages
1680-2issue
11eissn
0028-3878issn
1526-632Xjournal_volume
58pub_type
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