Abstract:
:Inclusion-body myositis (IBM) is an inflammatory muscle disease that has proven resistant to treatment. Tumor necrosis factor molecules have been detected in muscle biopsies from patients with IBM. Etanercept is a TNFalpha receptor fusion protein that binds and inactivates tumor necrosis factor. Nine patients were treated with etanercept at a dose of 25 mg, two times a week for an average of 17 +/- 6.1 months. Each patient was evaluated using quantitative strength testing. Their data were compared to two different control groups. The first control group consisted of patients who participated in trials of beta-interferon-1A and had received placebo. There was no significant difference. The second control group was a natural history cohort of IBM patients. There was no statistically significant difference between the treated group and the natural history group at 6 and 12 months when looking at elbow flexors, or 6 months when looking at hand grip. In the treated patients there was a small but significant improvement (p = 0.002) in handgrip at 12 months.
journal_name
Neurologyjournal_title
Neurologyauthors
Barohn RJ,Herbelin L,Kissel JT,King W,McVey AL,Saperstein DS,Mendell JRdoi
10.1212/01.wnl.0000192258.32408.54subject
Has Abstractpub_date
2006-01-24 00:00:00pages
S123-4issue
2 Suppl 1eissn
0028-3878issn
1526-632Xpii
66/1_suppl_1/S123journal_volume
66pub_type
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