Abstract:
:The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.
journal_name
Neurologyjournal_title
Neurologyauthors
Rosengren LE,Karlsson JE,Sjögren M,Blennow K,Wallin Adoi
10.1212/wnl.52.5.1090subject
Has Abstractpub_date
1999-03-23 00:00:00pages
1090-3issue
5eissn
0028-3878issn
1526-632Xjournal_volume
52pub_type
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