Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability.

abstract：:Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep. Primary treatment is directed at CNS dopaminergic systems, particularly activation of D(2)-like (D(2), D(3),...

journal_title：Neurology

authors： Clemens S,Rye D,Hochman S

更新日期：2006-07-11 00:00:00

abstract：:There is now increasing use of dopamine agonists as effective early monotherapy in the treatment of Parkinson's disease (PD). Dopamine agonists can induce an antiparkinsonian effect through actions on either D(1)-like or D(2)-like dopamine receptors, and the multiple receptor subtypes present in the brain may provide ...

journal_title：Neurology

authors： Jenner P

更新日期：2002-02-26 00:00:00

abstract：:Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...

journal_title：Neurology

authors： LeWitt PA,Nelson MV,Berchou RC,Galloway MP,Kesaree N,Kareti D,Schlick P

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:To investigate if patterns of CSF biomarkers (T-tau, P-tau, and Abeta42) can predict cognitive progression, outcome of cholinesterase inhibitor (ChEI) treatment, and mortality in Alzheimer disease (AD). METHODS:We included outpatients with AD (n = 151) from a prospective treatment study with ChEI. At baselin...

journal_title：Neurology

authors： Wallin AK,Blennow K,Zetterberg H,Londos E,Minthon L,Hansson O

更新日期：2010-05-11 00:00:00

abstract：OBJECTIVE:This article estimates lost work days and lost work day equivalents in a population sample of migraineurs, differentiating work loss due to headache episodes that met criteria for migraine from migrainous headaches not meeting full criteria and nonmigrainous headaches. METHODS:A random digit dialing survey o...

journal_title：Neurology

authors： Von Korff M,Stewart WF,Simon DJ,Lipton RB

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether tactile extinction alters the cortical somatosensory activations induced by hand vibration. BACKGROUND:Tactile extinction occurs mainly after right-brain lesions and consists of the inability to perceive a contralesional cutaneous stimulation when a similar stimulus is applied to the m...

journal_title：Neurology

authors： Remy P,Zilbovicius M,Degos JD,Bachoud-Lévi AC,Rancurel G,Cesaro P,Samson Y

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：:Fifty patients underwent superficial temporal lobectomy for intractable temporal lobe epilepsy. Total cure rate was 52%, and significant improvement was achieved in 88%. Cytoarchitectural changes in gray and white tissue were analyzed under light microscopy. Neuronal dysgenesis was correlated with the duration of seiz...

journal_title：Neurology

authors： Hardiman O,Burke T,Phillips J,Murphy S,O'Moore B,Staunton H,Farrell MA

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...

journal_title：Neurology

authors： Freeman JA,Hobart JC,Thompson AJ

更新日期：2001-07-10 00:00:00

abstract：BACKGROUND:Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. OBJECTIVE:To determine if neurocognitive deficits persist in 28-day abstinent heavy marijuana users and if these deficits are dose-...

journal_title：Neurology

authors： Bolla KI,Brown K,Eldreth D,Tate K,Cadet JL

更新日期：2002-11-12 00:00:00

abstract：:A woman with typical features of myoclonic epilepsy with ragged red fibers (MERRF) had a novel heteroplasmic mutation (G611A) in the mitochondrial DNA tRNA phenylalanine gene. The mutation was heteroplasmic (91%) in muscle but undetectable in accessible tissues from the patient and her maternal relatives. Single-fiber...

journal_title：Neurology

authors： Mancuso M,Filosto M,Mootha VK,Rocchi A,Pistolesi S,Murri L,DiMauro S,Siciliano G

更新日期：2004-06-08 00:00:00

abstract：OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...

journal_title：Neurology

authors： Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

更新日期：2020-02-25 00:00:00

abstract：:Minor head trauma precipitated oculomotor nerve palsies in two patients who subsequently were discovered to have ipsilateral posterior communicating artery aneurysms. A history of minor trauma should not dissuade investigation for underlying causes of oculomotor nerve palsy, including intracranial aneurysm. ...

journal_title：Neurology

authors： Walter KA,Newman NJ,Lessell S

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging an...

journal_title：Neurology

authors： Schultz MR,Lyons MJ,Franz CE,Grant MD,Boake C,Jacobson KC,Xian H,Schellenberg GD,Eisen SA,Kremen WS

更新日期：2008-05-06 00:00:00

abstract：OBJECTIVES:Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels to stroke severity has not been quantified. MRI measurements of lesion volume provide an objective method for stroke severity assessment and outcome pr...

journal_title：Neurology

authors： Bogoslovsky T,Chaudhry A,Latour L,Maric D,Luby M,Spatz M,Frank J,Warach S

更新日期：2010-12-07 00:00:00

abstract：:To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy (CIDP), the authors conducted a multicenter study on 312 patients with CIDP (199 responders and 113 nonresponders). Muscle atrophy and decreased compound muscle a...

journal_title：Neurology

authors： Iijima M,Yamamoto M,Hirayama M,Tanaka F,Katsuno M,Mori K,Koike H,Hattori N,Arimura K,Nakagawa M,Yoshikawa H,Hayasaka K,Onodera O,Baba M,Yasuda H,Saito T,Nakazato M,Nakashima K,Kira J,Kaji R,Oka N,Sobue G

更新日期：2005-04-26 00:00:00

abstract：:To test possible biochemical mechanisms by which L-tryptophan may reverse mental side effects of levodopa therapy in parkinsonism we administered levodopa, 250 mg per kilogram intraperitoneally, alone and with L-tryptophan, 500 mg per kilogram intraperitoneally, to rats pretreated with the peripheral dopa decarboxylas...

journal_title：Neurology

authors： Fahn S,Snider S,Prasad AL,Lane E,Makadon H

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that patients with Alzheimer disease (AD) who have vascular risk factors have a worse prognosis over 18 months vs those without such risk factors. METHODS:A sample of 224 people with AD and their caregivers were recruited purposively to be representative of people with dementia in term...

journal_title：Neurology

authors： Regan C,Katona C,Walker Z,Hooper J,Donovan J,Livingston G

更新日期：2006-10-24 00:00:00

abstract：OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...

journal_title：Neurology

authors： Burman J,Zelano J

更新日期：2017-12-12 00:00:00

abstract：OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...

journal_title：Neurology

authors： Norgren N,Sundström P,Svenningsson A,Rosengren L,Stigbrand T,Gunnarsson M

更新日期：2004-11-09 00:00:00

abstract：:In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...

journal_title：Neurology

authors： Lux WE,Kurtzke JF

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Previous work has suggested that functional reorganization of cortical motor areas might have a role in limiting the motor deficits in patients with MS. OBJECTIVE:To test whether movement-associated cortical changes in MS might extend beyond the "classic" motor areas and involve sites for multimodal integra...

journal_title：Neurology

authors： Rocca MA,Matthews PM,Caputo D,Ghezzi A,Falini A,Scotti G,Comi G,Filippi M

更新日期：2002-03-26 00:00:00

abstract：OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...

journal_title：Neurology

authors： Servidei S,Capon F,Spinazzola A,Mirabella M,Semprini S,de Rosa G,Gennarelli M,Sangiuolo F,Ricci E,Mohrenweiser HW,Dallapiccola B,Tonali P,Novelli G

更新日期：1999-09-11 00:00:00

abstract：:A man with onset of obsessive-compulsive disorder (OCD) at age 62 had a large right posterior frontal infarct and occlusion of the ipsilateral internal carotid artery. We review additional cases from the literature with obsessive or compulsive behaviors and structural lesions. OCD may have a structural correlate, and ...

journal_title：Neurology

authors： Swoboda KJ,Jenike MA

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:3-Methylglutaconic aciduria type I is a rare inborn error of leucine catabolism. It is thought to present in childhood with nonspecific symptoms; it was even speculated to be a nondisease. The natural course of disease is unknown. METHODS:This is a study on 10 patients with 3-methylglutaconic aciduria type I...

journal_title：Neurology

authors： Wortmann SB,Kremer BH,Graham A,Willemsen MA,Loupatty FJ,Hogg SL,Engelke UF,Kluijtmans LA,Wanders RJ,Illsinger S,Wilcken B,Cruysberg JR,Das AM,Morava E,Wevers RA

更新日期：2010-09-21 00:00:00

abstract：OBJECTIVE:To assess the effects of the modified amino acid acetyl-dl-leucine (AL) on cerebellar ataxia, eye movements, and quality of life of patients with Niemann-Pick type C (NP-C) disease. METHODS:Twelve patients with NP-C disease were treated with AL 3 g/d for 1 week and then with 5 g/d for 3 weeks with a subseque...

journal_title：Neurology

authors： Bremova T,Malinová V,Amraoui Y,Mengel E,Reinke J,Kolníková M,Strupp M

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Previously, hyperoxia and blood volume increase were reported in the red nucleus and substantia nigra during spontaneous migraine with aura. OBJECTIVE:To further understand the pathophysiologic role of these centers, activation of brainstem structures was investigated in patients with visually triggered mig...

journal_title：Neurology

authors： Cao Y,Aurora SK,Nagesh V,Patel SC,Welch KM

更新日期：2002-07-09 00:00:00

abstract：:We previously described demyelination in the brain and subacute combined degeneration of the spinal cord in a patient with 5,10-methylenetetrahydrofolate reductase deficiency. To assess the role of methionine, S-adenosylmethionine, folate, and neurotransmitter amine metabolism in the demyelination process, we measured...

journal_title：Neurology

authors： Hyland K,Smith I,Bottiglieri T,Perry J,Wendel U,Clayton PT,Leonard JV

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS). METHODS:We analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, ant...

journal_title：Neurology

authors： Choi H,Pack A,Elkind MS,Longstreth WT Jr,Ton TG,Onchiri F

更新日期：2017-02-28 00:00:00

abstract：:We measured beta-carbolinium cations (BC+s) endogenous analogs of the N-methyl-4-phenylpyridinium ion (MPP+), in the lumbar CSF of 22 patients with idiopathic Parkinson's disease (PD) and 11 age-matched controls without any symptoms of parkinsonism. Among the BC+s, 2,9-diemethylnorharmanium cation (2,9-Me2NH+), the mo...

journal_title：Neurology

authors： Matsubara K,Kobayashi S,Kobayashi Y,Yamashita K,Koide H,Hatta M,Iwamoto K,Tanaka O,Kimura K

更新日期：1995-12-01 00:00:00