Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective.

abstract：OBJECTIVE:To relate signs and symptoms to morphologic changes and presence of multiple mitochondrial DNA (mtDNA) deletions in a patient with autosomal dominant progressive external ophthalmoplegia (adPEO) and mitochondrial myopathy. BACKGROUND:An etiologic association between the somatic multiple mtDNA deletions in ad...

journal_title：Neurology

authors： Moslemi AR,Melberg A,Holme E,Oldfors A

更新日期：1999-07-13 00:00:00

abstract：:Eighty-one percent (47/58) of private-sector neurologists in Colorado responded to a mail survey of practice patterns. We evaluated patient load, degree of principal versus consultative care, and use of neurodiagnostic tests. Broad areas of neurologic education that were perceived to have been lacking during residency...

journal_title：Neurology

authors： Franklin GM,Ringel SP,Nelson LM,DeLapp C

更新日期：1987-02-01 00:00:00

abstract：:We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding...

journal_title：Neurology

authors： Hirayama M,Lisak RP,Silberberg DH

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:To assess cortical inhibitory and excitatory mechanisms in obsessive-compulsive disorder (OCD). BACKGROUND:Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette's syndrome, focal dystonia, and other ...

journal_title：Neurology

authors： Greenberg BD,Ziemann U,Corá-Locatelli G,Harmon A,Murphy DL,Keel JC,Wassermann EM

更新日期：2000-01-11 00:00:00

abstract：OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...

journal_title：Neurology

authors： Bower JH,Maraganore DM,Peterson BJ,McDonnell SK,Ahlskog JE,Rocca WA

更新日期：2003-05-27 00:00:00

abstract：:In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...

journal_title：Neurology

authors： Bernad PG,Szyfelbein WM,Weiss HD,Richardson EP Jr

更新日期：1980-01-01 00:00:00

abstract：:An emerging issue in stroke prevention and stroke treatment is that therapies shown to be effective in clinical trials are not being used or are being used suboptimally. One of many explanations relates to cost, ranging from concerns about inappropriate use of societal resources to more immediate concerns of organizat...

journal_title：Neurology

authors： Matchar DB

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. METHODS:In this cross-sectional study, spectral domain optical coherence tomography was used to analyze...

journal_title：Neurology

authors： Albrecht P,Blasberg C,Lukas S,Ringelstein M,Müller AK,Harmel J,Kadas EM,Finis D,Guthoff R,Aktas O,Hartung HP,Paul F,Brandt AU,Berlit P,Methner A,Kraemer M

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:To evaluate the time course of major vessel recanalization under IV thrombolysis in relation to functional outcome in acute ischemic stroke. METHODS:A total of 99 patients with an acute anterior circulation vessel occlusion who underwent IV thrombolysis were included. All patients had a standardized admissi...

journal_title：Neurology

authors： Wunderlich MT,Goertler M,Postert T,Schmitt E,Seidel G,Gahn G,Samii C,Stolz E,Duplex Sonography in Acute Stroke (DIAS) Study Group.,Competence Network Stroke.

更新日期：2007-04-24 00:00:00

abstract：OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...

journal_title：Neurology

authors： Tremlett H,Yousefi M,Devonshire V,Rieckmann P,Zhao Y,UBC Neurologists.

更新日期：2009-11-17 00:00:00

abstract：OBJECTIVE:To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations. METHODS:Data were analyzed from 57,247 patients with acute ischemic stroke receiving IV ...

journal_title：Neurology

authors： Mazya MV,Lees KR,Collas D,Rand VM,Mikulik R,Toni D,Wahlgren N,Ahmed N

更新日期：2015-12-15 00:00:00

abstract：:The authors evaluated how history of concussion affects symptom reporting prior to and after sustaining a concussion. At baseline, athletes with a positive concussion history reported more current symptomatology than athletes who had never been concussed. At 2 hours postinjury, concussed athletes with a history of pre...

journal_title：Neurology

authors： Bruce JM,Echemendia RJ

更新日期：2004-10-26 00:00:00

abstract：OBJECTIVE:To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls. METHODS:We included 64 patients with AD (67 +/- 9 years; F/M 38/26), 44 patients with MCI (71 +/- 6 yea...

journal_title：Neurology

authors： Henneman WJ,Sluimer JD,Barnes J,van der Flier WM,Sluimer IC,Fox NC,Scheltens P,Vrenken H,Barkhof F

更新日期：2009-03-17 00:00:00

abstract：OBJECTIVE:To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1). METHODS:A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, slee...

journal_title：Neurology

authors： Dauvilliers Y,Beziat S,Pesenti C,Lopez R,Barateau L,Carlander B,Luca G,Tafti M,Morin CM,Billiard M,Jaussent I

更新日期：2017-04-04 00:00:00

abstract：OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...

journal_title：Neurology

authors： Hervé D,Ibos-Augé N,Calvière L,Rogan C,Labeyrie MA,Guichard JP,Godin O,Kossorotoff M,Habert MO,Lasserve ET,Chevret S,Chabriat H

更新日期：2019-07-23 00:00:00

abstract：OBJECTIVES:More than a decade has passed since the last major workforce survey of child neurologists in the United States; thus, a reassessment of the child neurology workforce is needed, along with an inaugural assessment of a new related field, neurodevelopmental disabilities. METHODS:The American Academy of Pediatr...

journal_title：Neurology

authors： Kang PB,Bale JF Jr,Mintz M,Joshi SM,Gilbert DL,Radabaugh C,Ruch-Ross H,Section on Neurology Executive Committee of the American Academy of Pediatrics, and the Board of Directors of the Child Neurology Society.

更新日期：2016-09-27 00:00:00

abstract：:The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...

journal_title：Neurology

authors： Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

更新日期：2003-07-08 00:00:00

abstract：:Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clin...

journal_title：Neurology

authors： Klawans HL

更新日期：1981-05-01 00:00:00

abstract：:The local cerebral metabolic rate for glucose (1=CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p le...

journal_title：Neurology

authors： Bell RD,Alexander GM,Schwartzman RJ,Yu J

更新日期：1982-04-01 00:00:00

abstract：:Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects ...

journal_title：Neurology

authors： Frank S,Kieburtz K,Holloway R,Kim SY

更新日期：2005-10-11 00:00:00

abstract：:The presence of an APOE epsilon4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE epsilon4 in patients presenting with sensory predominant neuropathy. APOE epsilon4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance-associat...

journal_title：Neurology

authors： Zhou Z,Hoke A,Cornblath DR,Griffin JW,Polydefkis M

更新日期：2005-01-11 00:00:00

abstract：:Although a neuromuscular syndrome has been induced experimentally by vitamin E deficiency, a human syndrome has not yet been documented. This report describes a 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy,...

journal_title：Neurology

authors： Tomasi LG

更新日期：1979-08-01 00:00:00

abstract：:Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...

journal_title：Neurology

authors： Dimitrakoudis D,Bril V

更新日期：2002-08-27 00:00:00

abstract：:We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease (AD) with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the...

journal_title：Neurology

authors： Sobel E,Dunn M,Davanipour Z,Qian Z,Chui HC

更新日期：1996-12-01 00:00:00

abstract：:To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure...

journal_title：Neurology

authors： Borasio GD,Robberecht W,Leigh PN,Emile J,Guiloff RJ,Jerusalem F,Silani V,Vos PE,Wokke JH,Dobbins T

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To determine the contribution of sequence variations in PHOX2B to sudden unexpected death in epilepsy (SUDEP). METHODS:Patients who died of SUDEP were identified in 2 major Australian cohorts, the Epilepsy Genetics research program in Melbourne and postmortem cases at the Department of Forensic Medicine in S...

journal_title：Neurology

authors： Bagnall RD,Crompton DE,Cutmore C,Regan BM,Berkovic SF,Scheffer IE,Semsarian C

更新日期：2014-09-09 00:00:00

abstract：:We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...

journal_title：Neurology

authors： Barton JJ,Jama A,Sharpe JA

更新日期：1995-11-01 00:00:00

abstract：:A group of 204 muscular dystrophy patients were screened for immunohistochemical and biochemical alpha-sarcoglycan defect and their DNA was analyzed for pathogenetic mutation in the four sarcoglycan genes. We identified 21 patients with alpha-, beta-, or gamma-sarcoglycan gene mutations. Patients with alpha-sarcoglyca...

journal_title：Neurology

authors： Angelini C,Fanin M,Freda MP,Duggan DJ,Siciliano G,Hoffman EP

更新日期：1999-01-01 00:00:00

abstract：:The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...

journal_title：Neurology

authors： Diav-Citrin O,Shechtman S,Arnon J,Ornoy A

更新日期：2001-07-24 00:00:00

abstract：:Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. ...

journal_title：Neurology

authors： Orskov L,Jakobsen J,Dupont E,de Fine Olivarius B,Christensen NJ

更新日期：1987-07-01 00:00:00