Autosomal dominant progressive external ophthalmoplegia: distribution of multiple mitochondrial DNA deletions.

abstract：OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...

journal_title：Neurology

authors： Frohman EM,Zhang H,Kramer PD,Fleckenstein J,Hawker K,Racke MK,Frohman TC

更新日期：2001-09-11 00:00:00

abstract：:Between 1982 and 1989, 197 patients with Parkinson's disease were treated with selegiline and levodopa for at least 0.3 years. Two groups of patients were included: a group of 65 patients (stage 2 or 3 on the Hoehn and Yahr Scale) who recently had been started on levodopa and were not experiencing response fluctuation...

journal_title：Neurology

authors： Lieberman A

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. METHODS:A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measur...

journal_title：Neurology

authors： Musselman KE,Stoyanov CT,Marasigan R,Jenkins ME,Konczak J,Morton SM,Bastian AJ

更新日期：2014-01-07 00:00:00

abstract：OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...

journal_title：Neurology

authors： Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

更新日期：2017-09-26 00:00:00

abstract：:Many aging-associated neurologic disorders, including primary malignant brain tumors (MBT), share a common biphasic age-specific mortality rate pattern: initially increasing exponentially with age, and then declining. A modeling study using MBT mortality was conducted to determine if the observed biphasic pattern of M...

journal_title：Neurology

authors： Riggs JE

更新日期：2000-09-26 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg daily vs the approved 20-mg formulation in relapsing-remitting multiple sclerosis. METHODS:Eligibility criteria included clinically definite multiple sclerosis, Expanded Disability Status Scale score 0 to 5.0, no previous use...

journal_title：Neurology

authors： Cohen JA,Rovaris M,Goodman AD,Ladkani D,Wynn D,Filippi M,9006 Study Group.

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:Previous studies link posterior border-zone cerebral infarcts between the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) to hemodynamic causes, not embolism. OBJECTIVE:To study the cause of these infarcts. METHODS:We studied 21 patients (unilateral = 18, bilateral = 3) with acute, sym...

journal_title：Neurology

authors： Belden JR,Caplan LR,Pessin MS,Kwan E

更新日期：1999-10-12 00:00:00

abstract：:Five women are presented with a subacute pure pancerebellar syndrome of ataxia and dysarthria to emphasize that this illness may occur without anti-Purkinje-cell or anti-Yo antibodies, or associated systemic cancer. The syndrome evolved over weeks or less and stabilized in four of the patients. Three had had a precedi...

journal_title：Neurology

authors： Ropper AH

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The clinical characteristics of Tourette syndrome (TS) present challenges for the systematic determination of whether individuals are affected and severity. Vocal and motor tics wax and wane, decrease over time, and may be voluntarily suppressible, and therefore may be absent at interview. Current instrument...

journal_title：Neurology

authors： Robertson MM,Banerjee S,Kurlan R,Cohen DJ,Leckman JF,McMahon W,Pauls DL,Sandor P,van de Wetering BJ

更新日期：1999-12-10 00:00:00

abstract：OBJECTIVES:To learn caregivers' preferences for the treatment of AD with a disease-slowing therapy, and to identify relationships between these preferences and the characteristics of caregivers and patients. METHODS:A structured interview with 40 caregivers of patients with AD. Preferences were measured for an AD-slow...

journal_title：Neurology

authors： Karlawish JH,Klocinski JL,Merz J,Clark CM,Asch DA

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:There is a paucity of therapies for gait impairment in Parkinson disease (PD). Open-label studies have suggested improved gait after treatment with methylphenidate (MPD). OBJECTIVE:To evaluate the efficacy of MPD for the treatment of gait impairment in PD. METHODS:Twenty-seven subjects with PD and moderate...

journal_title：Neurology

authors： Espay AJ,Dwivedi AK,Payne M,Gaines L,Vaughan JE,Maddux BN,Slevin JT,Gartner M,Sahay A,Revilla FJ,Duker AP,Shukla R

更新日期：2011-04-05 00:00:00

abstract：:A 78-year-old woman presented with a right basal ganglia infarct 6 weeks after a left herpes zoster ophthalmicus. MR angiography showed focal segmental stenosis of the proximal segments of the anterior, middle, and posterior cerebral arteries. Varicella DNA was detected in the CSF by polymerase chain reaction (PCR). T...

journal_title：Neurology

authors： Melanson M,Chalk C,Georgevich L,Fett K,Lapierre Y,Duong H,Richardson J,Marineau C,Rouleau GA

更新日期：1996-08-01 00:00:00

abstract：:The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum...

journal_title：Neurology

authors： Bollensen E,Steck AJ,Schachner M

更新日期：1988-08-01 00:00:00

abstract：:There have been few descriptions of spontaneous epidural hematoma of the spinal cord in children. Duration of symptoms in previous cases has varied from hours to days. We recently evaluated a 6-year-old girl with cord compression from an extradural clot, who complained of thoracic back pain for 3 months before becomin...

journal_title：Neurology

authors： Robertson WC Jr,Lee YE,Edmonson MB

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...

journal_title：Neurology

authors： Khandaker G,Zurynski Y,Buttery J,Marshall H,Richmond PC,Dale RC,Royle J,Gold M,Snelling T,Whitehead B,Jones C,Heron L,McCaskill M,Macartney K,Elliott EJ,Booy R

更新日期：2012-10-02 00:00:00

abstract：OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...

journal_title：Neurology

authors： Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-10-29 00:00:00

abstract：:We enrolled 116 patients in a multicenter, randomized, double-blind controlled trial of an 8-week course of 11 plasma exchange (PE) treatments in exacerbations of MS. The control group received sham PE, and both groups received identical treatment with IM ACTH and oral cyclophosphamide. Serum IgG decreased in the PE a...

journal_title：Neurology

authors： Weiner HL,Dau PC,Khatri BO,Petajan JH,Birnbaum G,McQuillen MP,Fosburg MT,Feldstein M,Orav EJ

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:To assess cortical inhibitory and excitatory mechanisms in obsessive-compulsive disorder (OCD). BACKGROUND:Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette's syndrome, focal dystonia, and other ...

journal_title：Neurology

authors： Greenberg BD,Ziemann U,Corá-Locatelli G,Harmon A,Murphy DL,Keel JC,Wassermann EM

更新日期：2000-01-11 00:00:00

abstract：BACKGROUND:There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE:To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS:Ninety term neonates were s...

journal_title：Neurology

authors： Miller SP,Weiss J,Barnwell A,Ferriero DM,Latal-Hajnal B,Ferrer-Rogers A,Newton N,Partridge JC,Glidden DV,Vigneron DB,Barkovich AJ

更新日期：2002-02-26 00:00:00

abstract：:A 17-month-old boy developed herpes zoster ophthalmicus (HZO) and delayed contralateral hemiparesis following intrauterine varicella exposure. CT demonstrated multiple areas of hypodensity in the left basal ganglia, and angiography showed occlusion of left lenticulostriate arteries. As in most adults with HZO and dela...

journal_title：Neurology

authors： Leis AA,Butler IJ

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...

journal_title：Neurology

authors： Orkaby AR,Cho K,Cormack J,Gagnon DR,Driver JA

更新日期：2017-10-31 00:00:00

abstract：:Hirayama disease is a nonprogressive, asymmetric amyotrophy of the hands and forearms, possibly caused by compression of the lower cervical cord on neck flexion. The authors used phase-contrast MR angiography to study a patient with this disorder and observed abnormal spinal epidural venous dilation on neck flexion. I...

journal_title：Neurology

authors： Baba Y,Nakajima M,Utsunomiya H,Tsuboi Y,Fujiki F,Kusuhara T,Yamada T

更新日期：2004-04-27 00:00:00

abstract：OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...

journal_title：Neurology

authors： Gorson KC,Pessin MS,DeWitt LD,Caplan LR

更新日期：1996-02-01 00:00:00

abstract：:This review summarizes evidence, primarily from recent human studies, indirectly supporting a novel hypothesis: that the assessment of healthy individuals' responses to standardized noxious stimuli in a controlled laboratory environment has important implications for the later risk of developing a broad spectrum of ch...

journal_title：Neurology

authors： Edwards RR

更新日期：2005-08-09 00:00:00

abstract：OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...

journal_title：Neurology

authors： Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

更新日期：2010-03-16 00:00:00

abstract：:Using data from the compulsory Medical Birth Registry of Norway, the authors investigated the effect of maternal multiple sclerosis (MS) on pregnancy, delivery, and birth outcome in 649 births by MS mothers and 2.1 million control births. The mothers with MS had a higher proportion of neonates small for gestational ag...

journal_title：Neurology

authors： Dahl J,Myhr KM,Daltveit AK,Hoff JM,Gilhus NE

更新日期：2005-12-27 00:00:00

abstract：OBJECTIVE:To develop evidence-based recommendations for complementary and alternative medicine (CAM) in multiple sclerosis (MS). METHODS:We searched the literature (1970-March 2011; March 2011-September 2013 MEDLINE search), classified articles, and linked recommendations to evidence. RESULTS AND RECOMMENDATIONS:Clin...

journal_title：Neurology

authors： Yadav V,Bever C Jr,Bowen J,Bowling A,Weinstock-Guttman B,Cameron M,Bourdette D,Gronseth GS,Narayanaswami P

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:Treatment of aneurysmal subarachnoid hemorrhage (SAH) has changed substantially over the last 25 years but there is a lack of reliable population-based data on whether case-fatality or functional outcomes have improved. METHODS:We determined changes in the standardized incidence and outcome of SAH in the sa...

journal_title：Neurology

authors： Lovelock CE,Rinkel GJ,Rothwell PM

更新日期：2010-05-11 00:00:00

abstract：:A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...

journal_title：Neurology

authors： Bruno C,Minetti C,Shanske S,Morreale G,Bado M,Cordone G,DiMauro S

更新日期：1998-01-01 00:00:00

abstract：:The ability to deliver enzymatically active human hexosaminidase A across the blood-brain barrier and into brain cells of the normal rat was examined. Following osmotic blood-brain barrier modification in the rat, intraarterially administered human hexosaminidase A and B were shown to cross the barrier and enter brain...

journal_title：Neurology

authors： Neuwelt EA,Barranger JA,Pagel MA,Quirk JM,Brady RO,Frenkel EP

更新日期：1984-08-01 00:00:00