APOE epsilon4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy.

abstract：:In seven of eight patients with progressive multiple sclerosis subjected to long-term plasmapheresis in combination with azathioprine and pulsed prednisone therapy, we found modest improvement of neurologic function. There was no change in auditory and visual evoked responses or serum demyelinating activity. In six of...

journal_title：Neurology

authors： Dau PC,Petajan JH,Johnson KP,Panitch HS,Bornstein MB

更新日期：1980-10-01 00:00:00

abstract：:Magnetic resonance images (MRI), evoked responses (ER), and CSF findings were compared in 39 patients with possible, probable, or definite MS. MRI disclosed multiple lesions (72%) more often than ERs (55%) in the total group of patients. In possible MS, MRI showed multiple lesions in 71%, and ER abnormalities were fou...

journal_title：Neurology

authors： Farlow MR,Markand ON,Edwards MK,Stevens JC,Kolar OJ

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2. METHODS:VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients. Clinical and ...

journal_title：Neurology

authors： van Sonderen A,Schreurs MW,de Bruijn MA,Boukhrissi S,Nagtzaam MM,Hulsenboom ES,Enting RH,Thijs RD,Wirtz PW,Sillevis Smitt PA,Titulaer MJ

更新日期：2016-05-03 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...

journal_title：Neurology

authors： Janszky J,Woermann FG,Barsi P,Schulz R,Halász P,Ebner A

更新日期：2003-04-08 00:00:00

abstract：:Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron m...

journal_title：Neurology

authors： Mathis S,Le Masson G,Vallat JM

更新日期：2019-10-29 00:00:00

abstract：:Intracranial hypertension in the absence of an intracranial mass lesion or hydrocephalus can be caused by an alteration of one or more of the four determinants of cerebrospinal fluid (CSF) pressure: (1) intrasagittal sinus pressure, (2) resistance of arachnoid villi to the egress of CSF, (3) rate of production of CSF,...

journal_title：Neurology

authors： Donaldson JO

更新日期：1981-07-01 00:00:00

abstract：:One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (C...

journal_title：Neurology

authors： Fuccillo DA,Madden DL,Castellano GA,Uhlig L,Traub RG,Mattson J,Krezlewicz A,Sever JL

更新日期：1978-06-01 00:00:00

abstract：:Recent genetic studies show that the apolipoprotein E epsilon 4 allele (ApoE-epsilon 4) is a risk factor for Alzheimer's disease (AD). If ApoE-epsilon 4 individuals develop AD as they get older, we would expect a decrease in ApoE-epsilon 4 allele frequency with increasing age. We found a marked decline in ApoE-epsilon...

journal_title：Neurology

authors： Rebeck GW,Perls TT,West HL,Sodhi P,Lipsitz LA,Hyman BT

更新日期：1994-08-01 00:00:00

abstract：:Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...

journal_title：Neurology

authors： Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...

journal_title：Neurology

authors： Shefner JM,Liu D,Leitner ML,Schoenfeld D,Johns DR,Ferguson T,Cudkowicz M

更新日期：2016-08-09 00:00:00

abstract：OBJECTIVE:To characterize humoral response to cerebellum in patients with gluten ataxia. BACKGROUND:Gluten ataxia is a common neurologic manifestation of gluten sensitivity. METHODS:The authors assessed the reactivity of sera from patients with gluten ataxia (13), newly diagnosed patients with celiac disease without ...

journal_title：Neurology

authors： Hadjivassiliou M,Boscolo S,Davies-Jones GA,Grünewald RA,Not T,Sanders DS,Simpson JE,Tongiorgi E,Williamson CA,Woodroofe NM

更新日期：2002-04-23 00:00:00

abstract：:The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is lo...

journal_title：Neurology

authors： Rosengren LE,Karlsson JE,Sjögren M,Blennow K,Wallin A

更新日期：1999-03-23 00:00:00

abstract：OBJECTIVE:To describe the phenotype of adult patients with variant and classic ataxia-telangiectasia (A-T), to raise the degree of clinical suspicion for the diagnosis variant A-T, and to assess a genotype-phenotype relationship for mutations in the ATM gene. METHODS:Retrospective analysis of the clinical characterist...

journal_title：Neurology

authors： Verhagen MM,Abdo WF,Willemsen MA,Hogervorst FB,Smeets DF,Hiel JA,Brunt ER,van Rijn MA,Majoor Krakauer D,Oldenburg RA,Broeks A,Last JI,van't Veer LJ,Tijssen MA,Dubois AM,Kremer HP,Weemaes CM,Taylor AM,van Deuren M

更新日期：2009-08-11 00:00:00

abstract：OBJECTIVE:To analyze the spectrum and mechanisms of cutaneous adverse events (AEs) in patients with multiple sclerosis treated with daclizumab high-yield process (DAC-HYP). METHODS:A total of 31 participants in an institutional review board-approved open-label phase I study of DAC-HYP (NCT01143441) were prospectively ...

journal_title：Neurology

authors： Cortese I,Ohayon J,Fenton K,Lee CC,Raffeld M,Cowen EW,DiGiovanna JJ,Bielekova B

更新日期：2016-03-01 00:00:00

abstract：:A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropath...

journal_title：Neurology

authors： Thonnard JL,Detrembleur C,Van den Bergh PY

更新日期：1997-07-01 00:00:00

abstract：:A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...

journal_title：Neurology

authors： Rajan R,Khurana D,Kesav P

更新日期：2013-01-15 00:00:00

abstract：OBJECTIVE:To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders. METHODS:A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and selected movement disorders. Authors reviewed, a...

journal_title：Neurology

authors： Simpson DM,Blitzer A,Brashear A,Comella C,Dubinsky R,Hallett M,Jankovic J,Karp B,Ludlow CL,Miyasaki JM,Naumann M,So Y,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

更新日期：2008-05-06 00:00:00

abstract：:A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...

journal_title：Neurology

authors： Bruno C,Minetti C,Shanske S,Morreale G,Bado M,Cordone G,DiMauro S

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To assess whether lifetime physical activity during work and leisure time is associated with an increased risk of developing ALS and to determine the association between physical activity and duration or age at onset of disease. METHODS:Patients referred to our clinic during the 1-year period 2001 to 2002 wh...

journal_title：Neurology

authors： Veldink JH,Kalmijn S,Groeneveld GJ,Titulaer MJ,Wokke JH,van den Berg LH

更新日期：2005-01-25 00:00:00

abstract：:We studied the interrater variability among three neurologists of the diagnosis of a seizure in 100 patients evaluated for a possible "first seizure." We found that use of simple descriptive diagnostic criteria and discussion among the neurologists themselves improved the diagnostic agreement. ...

journal_title：Neurology

authors： van Donselaar CA,Geerts AT,Meulstee J,Habbema JD,Staal A

更新日期：1989-02-01 00:00:00

abstract：:Six members of a family had a neurologic disease with autosomal dominant transmission and adolescent onset of progressive wasting of predominantly distal axial muscles and muscles innervated by cranial nerves V, VII, X, and XII, leading to severe morbidity in adulthood. Muscle biopsy of the propositus revealed "ragged...

journal_title：Neurology

authors： Dobkin BH,Verity MA

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVE:We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in no...

journal_title：Neurology

authors： Zhan X,Stamova B,Jin LW,DeCarli C,Phinney B,Sharp FR

更新日期：2016-11-29 00:00:00

abstract：:Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The app...

journal_title：Neurology

authors： Jacobs L,Kinkel WR,Polachini I,Kinkel RP

更新日期：1986-01-01 00:00:00

abstract：:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...

journal_title：Neurology

authors： Sullivan CB,Visscher BR,Detels R

更新日期：1984-09-01 00:00:00

abstract：:The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...

journal_title：Neurology

authors： Dodson WE

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:On proton magnetic resonance spectroscopic imaging ((1)H MRSI), there is a decrease in cerebellar N-acetylaspartate/total creatine (NAA/tCr) in essential tremor (ET), signifying cerebellar neuronal dysfunction or degeneration. Harmane, which is present in the human diet, is a potent tremor-producing neurotox...

journal_title：Neurology

authors： Louis ED,Zheng W,Mao X,Shungu DC

更新日期：2007-08-07 00:00:00

abstract：BACKGROUND:Neutralizing antibodies (NAB) to interferon beta (IFNbeta) occur in about one-third of MS patients treated with IFNbeta-1b and there is an association with a loss of clinical and MRI efficacy. However, there are no data regarding the bioavailability of IFNbeta-1b in patients with and without NAB. METHODS:Th...

journal_title：Neurology

authors： Deisenhammer F,Reindl M,Harvey J,Gasse T,Dilitz E,Berger T

更新日期：1999-04-12 00:00:00

abstract：:Phenytoin suspension (PHY-S) is reported to settle, resulting in uneven drug distribution and variable patient dosing. We designed this study to determine the rate of settling and the amount of agitation needed to resuspend the preparation. To determine the rate of settling, we thoroughly shook three bottles of PHY-S ...

journal_title：Neurology

authors： Sarkar MA,Garnett WR,Karnes HT

更新日期：1989-02-01 00:00:00

abstract：:We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorph...

journal_title：Neurology

authors： Maraganore DM,Farrer MJ,Hardy JA,Lincoln SJ,McDonnell SK,Rocca WA

更新日期：1999-11-10 00:00:00

abstract：OBJECTIVE:To evaluate attention deficit in Alzheimer's disease (AD) and its relationship to attention deficits associated with aging and with medications altering alertness. METHODS:Ten patients with probable AD, 10 healthy old controls, and 15 young controls performed a covert orienting of spatial attention task. You...

journal_title：Neurology

authors： Oken BS,Kishiyama SS,Kaye JA,Howieson DB

更新日期：1994-04-01 00:00:00