Abstract:
:Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clinical response to levodopa was minimal, suggesting that the parkinsonism might have a postsynaptic striatal component. The clinical similarities of these four patients suggest that this is a distinct syndrome in which hemiparkinsonism is a late sequela of hemiatrophy. Identification of this syndrome has prognostic significance, because it seems to have a stereotyped course, remaining unilateral and only slowly progressive.
journal_name
Neurologyjournal_title
Neurologyauthors
Klawans HLdoi
10.1212/wnl.31.5.625subject
Has Abstractpub_date
1981-05-01 00:00:00pages
625-8issue
5eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
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