HIV-1 infection: no evidence of cognitive decline during the asymptomatic stages. The Multicenter AIDS Cohort Study.

Abstract:

:Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfected controls in the Multicenter AIDS Cohort Study with neuropsychological testing at semiannual intervals. A comparison of change in scores between visits 1 and 4 as well as a multivariate autoregressive analysis revealed no evidence of decline in test performance over time in the HIV-1-infected group compared with the seronegative controls. These findings suggest that a gradual cognitive decline does not occur during the early, asymptomatic stages of HIV infection.

journal_name

Neurology

journal_title

Neurology

authors

Selnes OA,Miller E,McArthur J,Gordon B,Muñoz A,Sheridan K,Fox R,Saah AJ

doi

10.1212/wnl.40.2.204

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

204-8

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

40

pub_type

临床试验,杂志文章,多中心研究
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  • Neurosyphilis in AIDS patients: initial CSF VDRL may be negative.

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    doi:10.1212/wnl.40.3_part_1.541

    authors: Feraru ER,Aronow HA,Lipton RB

    更新日期:1990-03-01 00:00:00

  • Sixty hertz pallidal deep brain stimulation for primary torsion dystonia.

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    doi:10.1212/wnl.27.10.959

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    更新日期:2008-04-22 00:00:00

  • Limb-kinetic apraxia in Parkinson disease.

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  • Basal ganglia dysmorphism in patients with Aicardi syndrome.

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    journal_title:Neurology

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    更新日期:2020-12-04 00:00:00

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  • Reduplicative paramnesia.

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  • Preclinical detection of Parkinson's disease: biochemical approaches.

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    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.41.5_suppl_2.34

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    更新日期:1991-05-01 00:00:00

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    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1995-04-01 00:00:00

  • Arterial wall properties in carotid artery dissection: an ultrasound study.

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    doi:10.1212/wnl.42.11.2168

    authors: Shoffner JM,Fernhoff PM,Krawiecki NS,Caplan DB,Holt PJ,Koontz DA,Takei Y,Newman NJ,Ortiz RG,Polak M

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  • Brugada syndrome in spinal and bulbar muscular atrophy.

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  • Factors influencing sweat gland innervation in diabetes.

    abstract:BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001488

    authors: Liu Y,Billiet J,Ebenezer GJ,Pan B,Hauer P,Wei J,Polydefkis M

    更新日期:2015-04-21 00:00:00

  • How transient are transient ischemic attacks?

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    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.5.674

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    更新日期:1988-05-01 00:00:00

  • Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.

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    journal_title:Neurology

    pub_type: 指南,杂志文章,实务指引,评审

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  • Predictors of outcome after anterior temporal lobectomy: the intracarotid amobarbital test.

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    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006029

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    doi:10.1212/wnl.53.2.382

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    更新日期:1999-07-22 00:00:00

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    pub_type: 传,历史文章,杂志文章

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    pub_type: 杂志文章

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  • The acoustic startle reflex in ischemic stroke.

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