Factors influencing osmotic fragility of red blood cells in Duchenne muscular dystrophy.

abstract：OBJECTIVE:To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies. METHODS:The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BA...

journal_title：Neurology

authors： Hellmuth J,Mirsky J,Heuer HW,Matlin A,Jafari A,Garbutt S,Widmeyer M,Berhel A,Sinha L,Miller BL,Kramer JH,Boxer AL

更新日期：2012-06-05 00:00:00

abstract：OBJECTIVE:To characterize a large family with X-linked Charcot-Marie-Tooth (CMT) neuropathy without mutations in the gap junction protein B1 (GJB1) gene, which has an unusual phenotype that is different in some aspects from classic CMTX1. METHODS:We tested CMT families consistent with X-linked inheritance for GJB1 mut...

journal_title：Neurology

authors： Huttner IG,Kennerson ML,Reddel SW,Radovanovic D,Nicholson GA

更新日期：2006-12-12 00:00:00

abstract：:Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...

journal_title：Neurology

authors： Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...

journal_title：Neurology

authors： Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:After Pokémon viewing triggered an epidemic of seizures in Japan, many efforts have been made to design safety guidelines and systems to protect subjects with photosensitivity. The authors developed a new method based upon nonlinear diffusion techniques capable of filtering the epileptogenic content of a vid...

journal_title：Neurology

authors： Parra J,Kalitzin SN,Stroink H,Dekker E,de Wit C,Lopes da Silva FH

更新日期：2005-03-08 00:00:00

abstract：OBJECTIVE:Unilateral temporoparietal injury may result in an attentional deficit for stimuli presented in contralesional space. Thus, bilateral temporoparietal degeneration associated with Alzheimer disease (AD) might result in a bilateral attentional disturbance. Tests for hemispatial neglect, however, primarily asses...

journal_title：Neurology

authors： Kim EJ,Lee BH,Seo SW,Moon SY,Jung DS,Park KH,Heilman KM,Na DL

更新日期：2007-09-11 00:00:00

abstract：OBJECTIVE:To quantify the associations of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell layer (mGCL) volume with cognitive functioning and to investigate how demographic and vascular health factors affect these associations in a population-based sample of adults. METHODS:The sampl...

journal_title：Neurology

authors： Ward DD,Mauschitz MM,Bönniger MM,Merten N,Finger RP,Breteler MMB

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...

journal_title：Neurology

authors： Dichgans M,Herzog J,Freilinger T,Wilke M,Auer DP

更新日期：2005-02-22 00:00:00

abstract：BACKGROUND:Previously, hyperoxia and blood volume increase were reported in the red nucleus and substantia nigra during spontaneous migraine with aura. OBJECTIVE:To further understand the pathophysiologic role of these centers, activation of brainstem structures was investigated in patients with visually triggered mig...

journal_title：Neurology

authors： Cao Y,Aurora SK,Nagesh V,Patel SC,Welch KM

更新日期：2002-07-09 00:00:00

abstract：:We studied recovery of function in 41 patients with right hemisphere stroke. Recovery was rapid for left neglect, prosopagnosia, anosognosia, and unilateral spatial neglect on drawing (USN). Recovery was slower for h mianopia, hemiparesis, motor impersistence, and extinction. Rates of recovery were intermediate for co...

journal_title：Neurology

authors： Hier DB,Mondlock J,Caplan LR

更新日期：1983-03-01 00:00:00

abstract：:Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...

journal_title：Neurology

authors： Ellgring H,Seiler S,Perleth B,Frings W,Gasser T,Oertel W

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:To examine whether prior statin use affects outcome and intracranial hemorrhage (ICH) rates in stroke patients receiving IV thrombolysis (IVT). METHODS:In a pooled observational study of 11 IVT databases, we compared outcomes between statin users and nonusers. Outcome measures were excellent 3-month outcome ...

journal_title：Neurology

authors： Engelter ST,Soinne L,Ringleb P,Sarikaya H,Bordet R,Berrouschot J,Odier C,Arnold M,Ford GA,Pezzini A,Zini A,Rantanen K,Rocco A,Bonati LH,Kellert L,Strbian D,Stoll A,Meier N,Michel P,Baumgartner RW,Leys D,Tatlisum

更新日期：2011-08-30 00:00:00

abstract：OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...

journal_title：Neurology

authors： Servidei S,Capon F,Spinazzola A,Mirabella M,Semprini S,de Rosa G,Gennarelli M,Sangiuolo F,Ricci E,Mohrenweiser HW,Dallapiccola B,Tonali P,Novelli G

更新日期：1999-09-11 00:00:00

abstract：OBJECTIVES:To determine the relative utility of 1H MRSI and hippocampal volumetry for the lateralization of mesial temporal lobe epilepsy (MTLE) in patients with intractable epilepsy. BACKGROUND:MTLE is the most common partial-onset seizure disorder in patients undergoing temporal lobe epilepsy surgery. MR volumetry a...

journal_title：Neurology

authors： Kuzniecky R,Hugg JW,Hetherington H,Butterworth E,Bilir E,Faught E,Gilliam F

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. OBJECTIVE:To investigate whether these Gulf War-related symptoms were associated with objective evidence of neuromuscular dysfunction. METHODS:Forty-nine Gulf War veterans with more than four neu...

journal_title：Neurology

authors： Sharief MK,Priddin J,Delamont RS,Unwin C,Rose MR,David A,Wessely S

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis. METHODS:Three hundred eighty-two patients with detailed information and functional status at 1 year were studied. Factors associated with poor status (defined as modified Rankin S...

journal_title：Neurology

authors： Balu R,McCracken L,Lancaster E,Graus F,Dalmau J,Titulaer MJ

更新日期：2019-01-15 00:00:00

abstract：:Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...

journal_title：Neurology

authors： Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

更新日期：1998-05-01 00:00:00

abstract：:We investigated potential risk factors for Alzheimer's disease (AD) in a clinicopathologic study of 407 patients with definite AD, 100 non-Alzheimer dementia patients, and 50 normal subjects. The AD patients had more first-degree relatives with dementia than the non-AD dementia group (odds ratio of 1.85, 95% confidenc...

journal_title：Neurology

authors： Mendez MF,Underwood KL,Zander BA,Mastri AR,Sung JH,Frey WH 2nd

更新日期：1992-04-01 00:00:00

abstract：:We investigated the role of ceruloplasmin in the antioxidative process in the brain in a patient with hereditary ceruloplasmin deficiency (HCD). Immunohistochemistry revealed an accumulation of Nepsilon-(carboxymethyl) lysine (CML) in basal ganglia of the HCD brain. In vitro study disclosed that ceruloplasmin inhibite...

journal_title：Neurology

authors： Tajima K,Kawanami T,Nagai R,Horiuchi S,Kato T

更新日期：1999-08-11 00:00:00

abstract：:We evaluated ventilation during cycle exercise in four men lacking myophosphorylase. In submaximal exercise of similar relative intensity, ventilation was higher relative to oxygen uptake in McArdle patients than in normal men. The exercise ventilatory response returned to normal after glucose infusion, by fasting to ...

journal_title：Neurology

authors： Haller RG,Lewis SF

更新日期：1986-05-01 00:00:00

abstract：:In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...

journal_title：Neurology

authors： Nino HE,Noreen HJ,Dubey DP,Resch JA,Namboodiri K,Elston RC,Yunis EJ

更新日期：1980-01-01 00:00:00

abstract：:Using diagnostic criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, dementia was clinically diagnosed in 57 (62%) of 92 centenarians living in two northern Italian provinces. The condition was severely disabling in approximately 70% of the demented patients. Although clinica...

journal_title：Neurology

authors： Ravaglia G,Forti P,De Ronchi D,Maioli F,Nesi B,Cucinotta D,Bernardi M,Cavalli G

更新日期：1999-07-22 00:00:00

abstract：:Permanent paralysis was induced in dogs by a 500 gram centimeter force injury on the spinal cord, and drug treatments were given 1 hour after injury and were continued for 3 days. Dogs were evaluated for 90 days. Isotonic saline or mannitol administration were ineffective in reversing the paralysis. In dogs receiving ...

journal_title：Neurology

authors： De La Torre JC,Johnson CM,Goode DJ,Mullan S

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Abnormal insulin metabolism may contribute to the clinical symptoms and pathophysiology of AD. In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden. METHODS:On separate mornings, 16 healthy older ad...

journal_title：Neurology

authors： Watson GS,Peskind ER,Asthana S,Purganan K,Wait C,Chapman D,Schwartz MW,Plymate S,Craft S

更新日期：2003-06-24 00:00:00

abstract：OBJECTIVE:To perform an open-label, long-term efficacy and safety/tolerability study of vagus nerve stimulation (VNS) of 454 patients with refractory epilepsy. METHODS:Subjects were enrolled from five clinical trials of VNS between 1988 and 1995 after undergoing an implantation of a pulse generator in the chest and a ...

journal_title：Neurology

authors： Morris GL 3rd,Mueller WM

更新日期：1999-11-10 00:00:00

abstract：:Plasma exchange (PE) was shown in a previous double-blind randomized controlled study to confer significant additional benefit at 1 year upon patients with chronic progressive multiple sclerosis (CPMS) treated with immunosuppressive drug therapy (ISDT). Efficacy over an extended term, indications for retreatment, and ...

journal_title：Neurology

authors： Khatri BO,McQuillen MP,Hoffmann RG,Harrington GJ,Schmoll D

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA. OBJECTIVE:To test if venlafaxine would relieve painful pol...

journal_title：Neurology

authors： Sindrup SH,Bach FW,Madsen C,Gram LF,Jensen TS

更新日期：2003-04-22 00:00:00

abstract：:We obtained continuous EEG/video recordings on four children who had the interictal EEG pattern of multifocal independent epileptiform discharges (MIED). The prominent feature of their evaluation was the evidence that their clinical seizures appeared to be of focal origin; 42/44 seizures were manifested by "fencing po...

journal_title：Neurology

authors： Burnstine TH,Vining EP,Uematsu S,Lesser RP

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial. METHODS:The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bila...

journal_title：Neurology

authors： Hacker ML,Turchan M,Heusinkveld LE,Currie AD,Millan SH,Molinari AL,Konrad PE,Davis TL,Phibbs FT,Hedera P,Cannard KR,Wang L,Charles D

更新日期：2020-07-28 00:00:00

abstract：OBJECTIVE:To report outcomes of pregnancies that occurred during the fingolimod clinical development program. METHODS:Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolim...

journal_title：Neurology

authors： Karlsson G,Francis G,Koren G,Heining P,Zhang X,Cohen JA,Kappos L,Collins W

更新日期：2014-02-25 00:00:00