Association of retinal layer measurements and adult cognitive function: A population-based study.

Abstract:

OBJECTIVE:To quantify the associations of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell layer (mGCL) volume with cognitive functioning and to investigate how demographic and vascular health factors affect these associations in a population-based sample of adults. METHODS:The sample included the first 3,000 participants (age range 30-95 years) of the Rhineland Study (recruited from March 2016 to December 2018) who underwent spectral-domain optical coherence tomography and cognitive assessment at 1 of 2 identical study centers in Bonn, Germany. We used multiple linear regression models to examine the relationships between retinal layer measurements and cognitive functioning after adjustment for confounders, and we examined the moderating effects of demographic and vascular health factors. RESULTS:The analytical sample included 2,483 participants who were 54.3 years old (SD 13.8 years) on average. After full adjustment, each 1-SD decrease in mGCL volume was associated with a greater decrease in global function than that of pRNFL thickness (β = -0.048 [95% confidence interval (CI) -0.077 to -0.018] vs β = -0.021 [95% CI -0.049 to 0.007]). These relationships increased in strength with advancing age, were stronger in participants with hypertension, and were reversed in current smokers relative to nonsmokers. CONCLUSIONS:mGCL volume is more strongly related to adult cognitive functioning than pRNFL thickness, making it a better potential biomarker of neurodegeneration. Age and vascular health factors play important roles in determining the strength and direction of this association.

journal_name

Neurology

journal_title

Neurology

authors

Ward DD,Mauschitz MM,Bönniger MM,Merten N,Finger RP,Breteler MMB

doi

10.1212/WNL.0000000000010146

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

e1144-e1152

issue

9

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000010146

journal_volume

95

pub_type

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