Abstract:
:We investigated the role of ceruloplasmin in the antioxidative process in the brain in a patient with hereditary ceruloplasmin deficiency (HCD). Immunohistochemistry revealed an accumulation of Nepsilon-(carboxymethyl) lysine (CML) in basal ganglia of the HCD brain. In vitro study disclosed that ceruloplasmin inhibited CML formation from glycated proteins through the reaction of Fe2+ with H2O2 by Fenton reaction. These data suggest that ceruloplasmin plays an important role in the protection of neurons against oxidative stress associated with iron metabolism.
journal_name
Neurologyjournal_title
Neurologyauthors
Tajima K,Kawanami T,Nagai R,Horiuchi S,Kato Tdoi
10.1212/wnl.53.3.619subject
Has Abstractpub_date
1999-08-11 00:00:00pages
619-22issue
3eissn
0028-3878issn
1526-632Xjournal_volume
53pub_type
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