Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy.

abstract：OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...

journal_title：Neurology

authors： Andrews RJ,Fonda JR,Levin LK,McGlinchey RE,Milberg WP

更新日期：2018-08-21 00:00:00

abstract：:Isovaleric acidemia (IVA) is an inborn error of leucine metabolism, resulting in an accumulation of isovaleric acid in the body fluids. The neuropathologic findings in an 11-day-old infant with IVA consisted of diffuse cerebral edema, massive cerebellar hemorrhage, upward transtentorial herniation, and focal degenerat...

journal_title：Neurology

authors： Fischer AQ,Challa VR,Burton BK,McLean WT

更新日期：1981-06-01 00:00:00

abstract：:The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...

journal_title：Neurology

authors： Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

更新日期：2006-04-25 00:00:00

abstract：:We describe a patient who presented with unilateral abdominal herniation due to weakness of abdominal musculature, associated with extensive syringomyelia. Electromyographic evidence of focal denervation and reinnervation was present in the weak muscles consistent with anterior horn cell loss. We compare these unusual...

journal_title：Neurology

authors： Coleman RJ,Ingram DA

更新日期：1991-10-01 00:00:00

abstract：:The rate of spontaneous resolution of a recently diagnosed solitary cerebral cysticercus granuloma as visualized on CT scan was prospectively studied in 210 patients presenting with seizures. The proportion of granulomas that had resolved completely at different time intervals after the index scan was 18.8% at 3 month...

journal_title：Neurology

authors： Rajshekhar V

更新日期：2001-12-26 00:00:00

abstract：OBJECTIVE:To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype. BACKGROUND:The apoE-4 allele is an important risk factor for AD. PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral met...

journal_title：Neurology

authors： Caselli RJ,Graff-Radford NR,Reiman EM,Weaver A,Osborne D,Lucas J,Uecker A,Thibodeau SN

更新日期：1999-07-13 00:00:00

abstract：:A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...

journal_title：Neurology

authors： Strom T,Schneck SA

更新日期：1991-02-01 00:00:00

abstract：:Cholinergic neurons in the nucleus ambiguus (NA) were counted in autopsy tissue obtained from five patients with multiple system atrophy (MSA), four patients with PD, and five controls. The number of neurons in the dorsal NA was not significantly different among the three groups. Neurons in the ventrolateral portion o...

journal_title：Neurology

authors： Benarroch EE,Schmeichel AM,Parisi JE

更新日期：2003-01-14 00:00:00

abstract：:Thirty-one individuals awaiting trial or sentencing for murder or undergoing an appeal process requested a neurologic examination through legal counsel. We attempted in each instance to obtain EEG, MRI or CT, and neuropsychological testing. Neurologic examination revealed evidence of "frontal" dysfunction in 20 (64.5%...

journal_title：Neurology

authors： Blake PY,Pincus JH,Buckner C

更新日期：1995-09-01 00:00:00

abstract：:Parry-Romberg syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive facial hemiatrophy. In this study, 205 patients with PRS were surveyed using the Internet. Estimates of the frequency of limb involvement (19%), epilepsy (11%), and other clinical and etiologic features were obtained. There was...

journal_title：Neurology

authors： Stone J

更新日期：2003-09-09 00:00:00

abstract：:The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...

journal_title：Neurology

authors： Lam CW,Yuen YP,Chan KY,Tong SF,Lai CK,Chow TC,Lee KC,Chan YW,Martiniuk F

更新日期：2003-02-25 00:00:00

abstract：:Using diagnostic criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, dementia was clinically diagnosed in 57 (62%) of 92 centenarians living in two northern Italian provinces. The condition was severely disabling in approximately 70% of the demented patients. Although clinica...

journal_title：Neurology

authors： Ravaglia G,Forti P,De Ronchi D,Maioli F,Nesi B,Cucinotta D,Bernardi M,Cavalli G

更新日期：1999-07-22 00:00:00

abstract：OBJECTIVE:To improve our understanding of early β-amyloid (Aβ) accumulation processes using florbetapir-PET scan in 20- to 60-year-old individuals. METHODS:Seventy-six cognitively normal individuals aged 20 to 60 years, 57 cognitively normal older individuals (61-84 years old), and 70 patients with mild cognitive impa...

journal_title：Neurology

authors： Gonneaud J,Arenaza-Urquijo EM,Mézenge F,Landeau B,Gaubert M,Bejanin A,de Flores R,Wirth M,Tomadesso C,Poisnel G,Abbas A,Desgranges B,Chételat G

更新日期：2017-12-12 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of onabotulinumtoxinA 100 U in noncatheterizing patients with multiple sclerosis (MS) with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS:In this randomized, double-blind phase III study, patients received onabotulinumtoxinA 100 U (n = 66)...

journal_title：Neurology

authors： Tullman M,Chartier-Kastler E,Kohan A,Keppenne V,Brucker BM,Egerdie B,Mandle M,Nicandro JP,Jenkins B,Denys P

更新日期：2018-08-14 00:00:00

abstract：OBJECTIVES:To examine whether preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) influenced 30-day stroke mortality. METHODS:We conducted a nationwide population-based cohort study. Using medical databases, we identified all first-time stroke hospitalizations in Denmark between 2004 and 2012 ...

journal_title：Neurology

authors： Schmidt M,Hováth-Puhó E,Christiansen CF,Petersen KL,Bøtker HE,Sørensen HT

更新日期：2014-11-25 00:00:00

abstract：OBJECTIVE:Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half of the patients. This study aimed to evaluate the effect of oral folic acid supplementation (0.5 mg/day) for the prevention of PHT-induced gingival overgrowth (PIGO) in children with epilepsy aged 6-15 years...

journal_title：Neurology

authors： Arya R,Gulati S,Kabra M,Sahu JK,Kalra V

更新日期：2011-04-12 00:00:00

abstract：:A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...

journal_title：Neurology

authors： Bloch SL,Jarrett MP,Swerdlow M,Grayzel AI

更新日期：1979-12-01 00:00:00

abstract：OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...

journal_title：Neurology

authors： Norgren N,Sundström P,Svenningsson A,Rosengren L,Stigbrand T,Gunnarsson M

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS). OBJECTIVE:To determine the incidence, clinical fe...

journal_title：Neurology

authors： Banwell B,Kennedy J,Sadovnick D,Arnold DL,Magalhaes S,Wambera K,Connolly MB,Yager J,Mah JK,Shah N,Sebire G,Meaney B,Dilenge ME,Lortie A,Whiting S,Doja A,Levin S,MacDonald EA,Meek D,Wood E,Lowry N,Buckley D,Yim

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear. METHODS:We conducted a systematic review and meta-analysis of clinical studies in any language published up to February 2008. We included studies re...

journal_title：Neurology

authors： Almekhlafi MA,Wilton SB,Rabi DM,Ghali WA,Lorenzetti DL,Hill MD

更新日期：2009-07-14 00:00:00

abstract：:Current concepts suggest that avoidance of pulsatile stimulation of dopamine receptors in Parkinson's disease (PD) can prevent the onset of dyskinesia. In MPTP-treated primates, repeated administration of levodopa or other short-acting dopamine agonist drugs leads to the onset of marked involuntary movements. In contr...

journal_title：Neurology

authors： Jenner P

更新日期：2004-01-13 00:00:00

abstract：OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...

journal_title：Neurology

authors： Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

更新日期：2020-01-07 00:00:00

abstract：OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...

journal_title：Neurology

authors： Michelson DJ,Shevell MI,Sherr EH,Moeschler JB,Gropman AL,Ashwal S

更新日期：2011-10-25 00:00:00

abstract：:We have used computerized tomography (CT) to look for evidence of cerebral demyelination in children with progressive neurologic disorders. Fourteen patients with a clinical diagnosis of a demyelinating disorder were examined by CT, and five had CT findings suggesting cerebral demyelination. In two patients with a so-...

journal_title：Neurology

authors： Robertson WC Jr,Gomez MR,Reese DF,Okazaki H

更新日期：1977-09-01 00:00:00

abstract：:Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS fr...

journal_title：Neurology

authors： Brugman F,Wokke JH,Vianney de Jong JM,Franssen H,Faber CG,Van den Berg LH

更新日期：2005-05-24 00:00:00

abstract：:We describe a 28-year-old woman presenting with hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency caused by a homozygous mutation consisting of a G-to-C transition in the initiation codon in exon 1 of the CYP17 gene resulting in expression of an enzymatically inactive truncated P450c17 protein....

journal_title：Neurology

authors： Satoh J,Kuroda Y,Nawata H,Yanase T

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...

journal_title：Neurology

authors： Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-10-29 00:00:00

abstract：:Thirty-eight survivors from among 117 patients hospitalized after out-of-hospital cardiac arrest were evaluated approximately 3 1/2 years later. Twenty patients were living; 18 had died. Fifty-three percent had resumed independent social activities, but only 32% had returned to work. Eight of 14 patients tested were n...

journal_title：Neurology

authors： Earnest MP,Yarnell PR,Merrill SL,Knapp GL

更新日期：1980-12-01 00:00:00

abstract：:Human subjects normally have miniature eye movements during tasks that require steady visual fixation. These eye movements were compared in 12 control subjects and 4 patients with degenerative cerebellar disorders. Slow drifts, small fixation saccades, square waves, saccadic oscillations, flutter, and vertical nystagm...

journal_title：Neurology

authors： Hotson JR

更新日期：1982-01-01 00:00:00

abstract：:We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...

journal_title：Neurology

authors： De Michele G,Perrone F,Filla A,Mirante E,Giordano M,De Placido S,Campanella G

更新日期：1996-11-01 00:00:00