Abstract:
:We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding a source of complement. Despite apparent lack of disease specificity, such factors might damage oligodendrocytes if they gained access to these cells through a damaged blood-brain barrier in MS or other disorders.
journal_name
Neurologyjournal_title
Neurologyauthors
Hirayama M,Lisak RP,Silberberg DHdoi
10.1212/wnl.36.2.276subject
Has Abstractpub_date
1986-02-01 00:00:00pages
276-8issue
2eissn
0028-3878issn
1526-632Xjournal_volume
36pub_type
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