Anticonvulsant and anesthetic barbiturates: different postsynaptic actions in cultured mammalian neurons.

abstract：:We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...

journal_title：Neurology

authors： Valls-Sole J,Tolosa ES

更新日期：1989-08-01 00:00:00

abstract：:Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...

journal_title：Neurology

authors： Snead OC 3rd,Yu RK,Huttenlocher PR

更新日期：1976-01-01 00:00:00

abstract：:With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications. In this article, four patient reports of a sp...

journal_title：Neurology

authors： Diamond S,Pepper BJ,Diamond ML,Freitag FG,Urban GJ,Erdemoglu AK

更新日期：1998-07-01 00:00:00

abstract：:Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. ...

journal_title：Neurology

authors： Orskov L,Jakobsen J,Dupont E,de Fine Olivarius B,Christensen NJ

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...

journal_title：Neurology

authors： Dymek MP,Atchison P,Harrell L,Marson DC

更新日期：2001-01-09 00:00:00

abstract：:Minor head trauma precipitated oculomotor nerve palsies in two patients who subsequently were discovered to have ipsilateral posterior communicating artery aneurysms. A history of minor trauma should not dissuade investigation for underlying causes of oculomotor nerve palsy, including intracranial aneurysm. ...

journal_title：Neurology

authors： Walter KA,Newman NJ,Lessell S

更新日期：1994-01-01 00:00:00

abstract：:A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...

journal_title：Neurology

authors： Blumenfeld AM,Recht LD,Chad DA,DeGirolami U,Griffin T,Jaeckle KA

更新日期：1991-10-01 00:00:00

abstract：:We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there ...

journal_title：Neurology

authors： Duquette P,Pleines J,du Souich P

更新日期：1985-12-01 00:00:00

abstract：:We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...

journal_title：Neurology

authors： Amarenco P,Roullet E,Goujon C,Chéron F,Hauw JJ,Bousser MG

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...

journal_title：Neurology

authors： Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

更新日期：2002-04-09 00:00:00

abstract：OBJECTIVE:To test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults. METHODS:We studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with a...

journal_title：Neurology

authors： Buchman AS,Dawe RJ,Yu L,Lim A,Wilson RS,Schneider JA,Bennett DA

更新日期：2018-05-22 00:00:00

abstract：OBJECTIVE:To determine the relationship between hippocampal, amygdalar, and entorhinal cortex atrophy and duration of epilepsy, presence of secondary generalized seizures, and prolonged childhood febrile convulsions in patients with pharmacologically intractable temporal lobe epilepsy (TLE). METHODS:Volumetric MRI of ...

journal_title：Neurology

authors： Bernasconi N,Natsume J,Bernasconi A

更新日期：2005-07-26 00:00:00

abstract：OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility ...

journal_title：Neurology

authors： Dilokthornsakul P,Valuck RJ,Nair KV,Corboy JR,Allen RR,Campbell JD

更新日期：2016-03-15 00:00:00

abstract：:Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...

journal_title：Neurology

authors： Fayad PB,Awad IA

更新日期：1998-09-01 00:00:00

abstract：:The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...

journal_title：Neurology

authors： Lam CW,Yuen YP,Chan KY,Tong SF,Lai CK,Chow TC,Lee KC,Chan YW,Martiniuk F

更新日期：2003-02-25 00:00:00

abstract：OBJECTIVES:Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS:Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, an...

journal_title：Neurology

authors： Kerchner GA,Berdnik D,Shen JC,Bernstein JD,Fenesy MC,Deutsch GK,Wyss-Coray T,Rutt BK

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:Silas Weir Mitchell (1829 to 1914), one of the most important neurologists in American Medicine, was known for his seminal work on the phantom limb syndrome, causalgia, and nerve injuries. He was also a prolific writer of novels and short stories. The neurologic content of this fiction has not been studied. ...

journal_title：Neurology

authors： Louis ED,Horn S,Roth LA

更新日期：2006-02-14 00:00:00

abstract：BACKGROUND:The 1875 publications of Erb and Westphal brought widespread attention to the percussion of muscle stretch reflexes. Although the maneuver may have been observed before 1875, there is little concrete evidence of this. OBJECTIVES:To bring to light an early report of percussion eliciting the muscle stretch re...

journal_title：Neurology

authors： Louis ED

更新日期：2008-03-18 00:00:00

abstract：:Mitochondrial and cytoplasmic malic isoenzymes were assayed fluorometrically in digitonin-fractionated fibroblasts from three patients with Friedreich's ataxia (FA). Normal activity was found, failing to verify an earlier report of reduced fibroblast mitochondrial malic enzyme activity in FA. The previously reported d...

journal_title：Neurology

authors： Fernandez RJ,Civantos F,Tress E,Maltese WA,De Vivo DC

更新日期：1986-06-01 00:00:00

abstract：:A 42-year-old man had progressive distal weakness and muscle atrophy, stocking-type sensory loss, upper motor-neuron and visual pathway lesions, and dysautonomia. Electrodiagnostic tests revealed a generalized sensorimotor peripheral neuropathy that largely involved axons. Low recumbent and upright norepinephrine leve...

journal_title：Neurology

authors： Rechthand E,Reife R,Kaplan JG

更新日期：1983-11-01 00:00:00

abstract：:To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...

journal_title：Neurology

authors： Laxer KD,Sourkes TL,Fang TY,Young SN,Gauthier SG,Missala K

更新日期：1979-08-01 00:00:00

abstract：:We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...

journal_title：Neurology

authors： Fetell MR,Bruce JN,Burke AM,Cross DT,Torres RA,Powers JM,Stein BM

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...

journal_title：Neurology

authors： Sirven JI,Claypool DW,Sahs KL,Wingerchuk DM,Bortz JJ,Drazkowski J,Caselli R,Zanick D

更新日期：2002-06-25 00:00:00

abstract：OBJECTIVE:We aimed to assess sensitivity and specificity of the updated criteria for behavioral variant frontotemporal dementia (bvFTD) based on a large autopsy-confirmed cohort of patients with dementia. METHODS:Two hundred thirty-nine consecutive pathologically confirmed dementia patients, clinically assessed in a s...

journal_title：Neurology

authors： Harris JM,Gall C,Thompson JC,Richardson AM,Neary D,du Plessis D,Pal P,Mann DM,Snowden JS,Jones M

更新日期：2013-05-14 00:00:00

abstract：:4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for t...

journal_title：Neurology

authors： Smits RC,Emmen HH,Bertelsmann FW,Kulig BM,van Loenen AC,Polman CH

更新日期：1994-09-01 00:00:00

abstract：:Ten patients with refractory temporal lobe epilepsy performed a word-position association learning task every 24 hours during video EEG monitoring. On 55 occasions recall performance was tested 30 minutes and 24 hours after the initial learning phase. Patients with left- but not right-sided temporal lobe epilepsy exhi...

journal_title：Neurology

authors： Jokeit H,Daamen M,Zang H,Janszky J,Ebner A

更新日期：2001-07-10 00:00:00

abstract：:In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...

journal_title：Neurology

authors： Loonen MC,Busch HF,Koster JF,Martin JJ,Niermeijer MF,Schram AW,Brouwer-Kelder B,Mekes W,Slee RG,Tager JM

更新日期：1981-10-01 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：:The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

journal_title：Neurology

authors： Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

更新日期：1988-08-01 00:00:00

abstract：:CNS dysfunction occurs frequently in patients with HIV infection. To better define the role of HIV in the pathogenesis of neurologic dysfunction, HIV isolation and antibody studies were investigated from the CSF in 52 seropositive patients, 29 with and 23 without neurologic signs and symptoms, in various stages of dis...

journal_title：Neurology

authors： Resnick L,Berger JR,Shapshak P,Tourtellotte WW

更新日期：1988-01-01 00:00:00