Ictal downbeat nystagmus in Ménière disease: A cross-sectional study.

Abstract:

OBJECTIVE:To determine the mechanism of ictal downbeat nystagmus in Ménière disease (MD), we compared the head impulse gain of the vestibulo-ocular reflex (VOR) for each semicircular canal between patients with (n = 7) and without (n = 70) downbeat nystagmus during attacks of MD. METHODS:We retrospectively analyzed the results of video-oculography, video head-impulse tests, and cervical vestibular-evoked myogenic potentials (VEMPs) in 77 patients with definite MD who were evaluated during an attack. RESULTS:Pure or predominant downbeat nystagmus was observed in 7 patients (9%) with unilateral MD during the attacks. All 7 patients showed spontaneous downbeat nystagmus without visual fixation with a slow phase velocity ranging from 1.5 to 11.2°/s (median 5.4, interquartile range 3.7-8.5). All showed a transient decrease of the head impulse VOR gains for the posterior canals (PCs) in both ears (n = 4) or in the affected ear (n = 3). Cervical VEMPs were decreased in the affected (n = 2) or both ears (n = 2) when evaluated during the attacks. Downbeat nystagmus disappeared along with normalization of the VOR gains for PCs after the attacks in all patients. During the attacks, the head impulse VOR gains for the PC on the affected side were lower in the patients with ictal downbeat nystagmus than in those without (Mann-Whitney U test, p < 0.001), while the gains for other semicircular canals did not differ between the groups. CONCLUSION:Downbeat nystagmus may be observed during attacks of MD due to an asymmetry in the vertical VOR or saccular dysfunction. MD should be considered in recurrent audiovestibulopathy and ictal downbeat nystagmus.

journal_name

Neurology

journal_title

Neurology

authors

Lee SU,Kim HJ,Choi JY,Kim JS

doi

10.1212/WNL.0000000000010653

subject

Has Abstract

pub_date

2020-10-27 00:00:00

pages

e2409-e2417

issue

17

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000010653

journal_volume

95

pub_type

杂志文章
  • The effect of nerve growth factor, ciliary neurotrophic factor, and ACTH analogs on cisplatin neurotoxicity in vitro.

    abstract::Cisplatin, used to treat ovarian, bladder, and testicular cancers, causes a sensory dose-limiting neuropathy. Preliminary observations in humans and animals suggest that nerve damage may be prevented by ACTH analogs, particularly those belonging to the melanocortin class, and by nerve growth factor (NGF). We establish...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.3_part_1.488

    authors: Windebank AJ,Smith AG,Russell JW

    更新日期:1994-03-01 00:00:00

  • Estrogen-withdrawal migraine. I. Duration of exposure required and attempted prophylaxis by premenstrual estrogen administration.

    abstract::The minimum exposure to estrogen required to cause estrogen-withdrawal migraine has been studied by giving long-acting estradiol valerate to four women and short-acting estradiol benzoate to two women. It was found that several days of exposure to high estrogen levels were needed to cause migraine on estrogen withdraw...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.25.3.239

    authors: Somerville BW

    更新日期:1975-03-01 00:00:00

  • Disconnection as a mechanism for social cognition impairment in multiple sclerosis.

    abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004060

    authors: Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

    更新日期:2017-07-04 00:00:00

  • Effects of valproic acid in cultured mammalian neurons.

    abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.2.259

    authors: Buchhalter JR,Dichter MA

    更新日期:1986-02-01 00:00:00

  • A novel sodium channel mutation in a family with hypokalemic periodic paralysis.

    abstract:OBJECTIVE:To identify the cause of hypokalemic periodic paralysis (HOKPP) in a family whose disease is not caused by a mutation in the dihydropyridine-sensitive (DHP) receptor alpha1-subunit gene (CACNA1S). BACKGROUND:Hypokalemic periodic paralysis is primarily caused by mutations within CACNA1S. Genetic heterogeneity...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.9.1932

    authors: Bulman DE,Scoggan KA,van Oene MD,Nicolle MW,Hahn AF,Tollar LL,Ebers GC

    更新日期:1999-12-10 00:00:00

  • Individual differences in endogenous pain modulation as a risk factor for chronic pain.

    abstract::This review summarizes evidence, primarily from recent human studies, indirectly supporting a novel hypothesis: that the assessment of healthy individuals' responses to standardized noxious stimuli in a controlled laboratory environment has important implications for the later risk of developing a broad spectrum of ch...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000171862.17301.84

    authors: Edwards RR

    更新日期:2005-08-09 00:00:00

  • Sudomotor function in human poikilothermia.

    abstract::Hypohidrosis predisposes to hyperthermia and may indicate generalized thermoregulatory failure. To assess the sweating capacity in human poikilothermia, we performed a quantitative analysis of the central and peripheral sudomotor pathways in four women with acquired poikilothermia (aged 29 to 38 years) and nine contro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.8.1602

    authors: MacKenzie MA,Schönbaum E,Hermus AR,Wollersheim HC,Thien T,Smals AG,Kloppenborg PW

    更新日期:1995-08-01 00:00:00

  • Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?

    abstract::Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/wnl.46.3.641

    authors: Lautenschlager NT,Cupples LA,Rao VS,Auerbach SA,Becker R,Burke J,Chui H,Duara R,Foley EJ,Glatt SL,Green RC,Jones R,Karlinsky H,Kukull WA,Kurz A,Larson EB,Martelli K,Sadovnick AD,Volicer L,Waring SC,Growdon JH,Fa

    更新日期:1996-03-01 00:00:00

  • THIP treatment of Huntington's disease.

    abstract::We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.33.5.637

    authors: Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

    更新日期:1983-05-01 00:00:00

  • The one-and-a-half syndrome--a unilateral disorder of the pontine tegmentum: a study of 20 cases and review of the literature.

    abstract::The one-and-a-half syndrome is a clinical disorder of extraocular movements characterized by a conjugate horizontal gaze palsy in one direction plus an internuclear ophthalmoplegia in the other. The syndrome is usually due to a single unilateral lesion of the paramedian pontine reticular formation or the abducens nucl...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.8.971

    authors: Wall M,Wray SH

    更新日期:1983-08-01 00:00:00

  • Primary intramedullary spinal cord lymphoma.

    abstract:OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31822b00b9

    authors: Flanagan EP,O'Neill BP,Porter AB,Lanzino G,Haberman TM,Keegan BM

    更新日期:2011-08-23 00:00:00

  • Trajectories of brain loss in aging and the development of cognitive impairment.

    abstract:BACKGROUND:The use of volumetric MRI as a biomarker for assessing transitions to dementia presumes that more rapid brain loss marks the clinical transition from benign aging to mild cognitive impairment (MCI). The trajectory of this volume loss relative to the timing of the clinical transition to dementia has not been ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000280577.43413.d9

    authors: Carlson NE,Moore MM,Dame A,Howieson D,Silbert LC,Quinn JF,Kaye JA

    更新日期:2008-03-11 00:00:00

  • Generalized epilepsy in hypothalamic hamartoma: evolution and postoperative resolution.

    abstract:OBJECTIVE:To better understand the epileptogenesis of symptomatic generalized epilepsy in patients with hypothalamic hamartoma and intractable epilepsy, many of whom experience remission of generalized seizures and slow spike-wave discharges following surgery. METHODS:The authors documented the evolution of symptomati...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000049457.05670.7d

    authors: Freeman JL,Harvey AS,Rosenfeld JV,Wrennall JA,Bailey CA,Berkovic SF

    更新日期:2003-03-11 00:00:00

  • Treatment of Bell palsy with prednisone: a prospective, randomized study.

    abstract::Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; mot...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.28.2.158

    authors: Wolf SM,Wagner JH,Davidson S,Forsythe A

    更新日期:1978-02-01 00:00:00

  • Right hippocampal sclerosis is more common than left after febrile seizures.

    abstract::Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/01.wnl.0000052823.29467.a0

    authors: Janszky J,Woermann FG,Barsi P,Schulz R,Halász P,Ebner A

    更新日期:2003-04-08 00:00:00

  • A T-->C mutation at nt 8993 of mitochondrial DNA in a child with Leigh syndrome.

    abstract::A 5-year-old child with clinical and radiologic evidence of Leigh syndrome (LS) showed a T-->C mutation at position nt 8993 in the mitochondrial DNA (instead of the more common T-->G substitution), resulting in an amino acid change from a highly conserved leucine to proline in subunit 6 of mitochondrial ATPase. The mu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.5.972

    authors: Santorelli FM,Shanske S,Jain KD,Tick D,Schon EA,DiMauro S

    更新日期:1994-05-01 00:00:00

  • "Dark Victory" (prognosis negative): The beginnings of neurology on screen.

    abstract::In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to t...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0000000000002571

    authors: Wijdicks EFM

    更新日期:2016-04-12 00:00:00

  • Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation.

    abstract:OBJECTIVE:To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS:We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classificati...

    journal_title:Neurology

    pub_type: 指南,杂志文章,评审

    doi:10.1212/WNL.0b013e3182166ebe

    authors: Bril V,England J,Franklin GM,Backonja M,Cohen J,Del Toro D,Feldman E,Iverson DJ,Perkins B,Russell JW,Zochodne D,American Academy of Neurology.,American Association of Neuromuscular and Electrodiagnostic Medicine.,American Acade

    更新日期:2011-05-17 00:00:00

  • Cerebrovascular disease in childhood cancer survivors: A Children's Oncology Group Report.

    abstract:BACKGROUND:Curative therapy for childhood cancer has dramatically improved over past decades. Therapeutic radiation has been instrumental in this success. Unfortunately, irradiation is associated with untoward effects, including stroke and other cerebrovascular disease (CVD). The Children's Oncology Group (COG) has dev...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e3181c17ea8

    authors: Morris B,Partap S,Yeom K,Gibbs IC,Fisher PG,King AA

    更新日期:2009-12-01 00:00:00

  • Efficacy of subcutaneous sumatriptan in repeated episodes of migraine.

    abstract::This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires asse...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.43.7.1363

    authors: Cady RK,Dexter J,Sargent JD,Markley H,Osterhaus JT,Webster CJ

    更新日期:1993-07-01 00:00:00

  • Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo.

    abstract::We performed proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with motor neuron disease (MND) to evaluate the distribution and extent of cortical neuron damage or loss as reflected by decreased N-acetyl (NA) to creatine (Cr) resonance intensity ratios. We examined premotor (superior frontal gyrus)...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.44.10.1933

    authors: Pioro EP,Antel JP,Cashman NR,Arnold DL

    更新日期:1994-10-01 00:00:00

  • Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.

    abstract:OBJECTIVE:To test efficacy and safety of atorvastatin in subjects with clinically isolated syndrome (CIS). METHODS:Subjects with CIS were enrolled in a phase II, double-blind, placebo-controlled, 14-center randomized trial testing 80 mg atorvastatin on clinical and brain MRI activity. Brain MRIs were performed quarter...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1212/WNL.0b013e31824f7fdd

    authors: Waubant E,Pelletier D,Mass M,Cohen JA,Kita M,Cross A,Bar-Or A,Vollmer T,Racke M,Stüve O,Schwid S,Goodman A,Kachuck N,Preiningerova J,Weinstock-Guttman B,Calabresi PA,Miller A,Mokhtarani M,Iklé D,Murphy S,Kopetskie

    更新日期:2012-04-10 00:00:00

  • Discrepancy between stimulus response and tolerance of pain in Alzheimer disease.

    abstract:BACKGROUND:Affective-motivational and sensory-discriminative aspects of pain were investigated in patients with mild to moderate Alzheimer disease (AD) and healthy elderly controls using the cold pressor test tolerance and repetitive stimuli of warmth and heat stimuli, evaluating the stimulus-response function. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001465

    authors: Jensen-Dahm C,Werner MU,Jensen TS,Ballegaard M,Andersen BB,Høgh P,Waldemar G

    更新日期:2015-04-14 00:00:00

  • Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later.

    abstract:OBJECTIVES:We compared the ability of molecular biomarkers for Alzheimer disease (AD), including amyloid imaging and CSF biomarkers (Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42), to predict time to incident cognitive impairment among cognitively normal adults aged 45 to 88 years and followed for up to 7.5 years. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182918ca6

    authors: Roe CM,Fagan AM,Grant EA,Hassenstab J,Moulder KL,Maue Dreyfus D,Sutphen CL,Benzinger TL,Mintun MA,Holtzman DM,Morris JC

    更新日期:2013-05-07 00:00:00

  • Imipramine in absence and myoclonic-astatic seizures.

    abstract::A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintai...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.28.9.953

    authors: Fromm GH,Wessel HB,Glass JD,Alvin JD,Van Horn G

    更新日期:1978-09-01 00:00:00

  • Doxycycline and intracranial hypertension.

    abstract::The authors report seven patients from six neuro-ophthalmology referral centers who developed pseudo-tumor cerebri during treatment with doxycycline. All four female patients and one of three male patients were obese. Vision was minimally affected in most patients, but two had substantial visual acuity or visual field...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.62.12.2297

    authors: Friedman DI,Gordon LK,Egan RA,Jacobson DM,Pomeranz H,Harrison AR,Goldhammer Y

    更新日期:2004-06-22 00:00:00

  • Neurologic abnormalities in murderers.

    abstract::Thirty-one individuals awaiting trial or sentencing for murder or undergoing an appeal process requested a neurologic examination through legal counsel. We attempted in each instance to obtain EEG, MRI or CT, and neuropsychological testing. Neurologic examination revealed evidence of "frontal" dysfunction in 20 (64.5%...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.9.1641

    authors: Blake PY,Pincus JH,Buckner C

    更新日期:1995-09-01 00:00:00

  • A new complication of AIDS: thoracic myelitis caused by herpes simplex virus.

    abstract::Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.7.1071

    authors: Britton CB,Mesa-Tejada R,Fenoglio CM,Hays AP,Garvey GG,Miller JR

    更新日期:1985-07-01 00:00:00

  • Saccades in children with spina bifida and Chiari type II malformation.

    abstract:BACKGROUND:Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida. OBJECTIVE:To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements. METHODS:Saccade...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000166034.71337.5E

    authors: Salman MS,Sharpe JA,Eizenman M,Lillakas L,To T,Westall C,Steinbach MJ,Dennis M

    更新日期:2005-06-28 00:00:00

  • Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine.

    abstract:OBJECTIVE:The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000005622

    authors: Schulte LH,Allers A,May A

    更新日期:2018-05-29 00:00:00