Abstract:
OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven with dementia of the Alzheimer's type (AD) (aged 72 +/- 9 years, mean +/- SD). This method, based on the Masserman technique, employs ventricular rather than a lumbar access to the CSF space. Furthermore, the volume of CSF removed during the procedure is only 3 mL rather than 10 mL. RESULTS:These measurements indicate that the mean rate of CSF production in patients with PD under age 60 was 0.47 +/- 0.13 mL/minute, in patients with PD aged 60 or older the mean rate was 0.40 +/- 0.12 mL/minute, and in patients with AD the mean rate was 0.20 +/- 0.06 mL/minute. CONCLUSION:These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced.
journal_name
Neurologyjournal_title
Neurologyauthors
Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TAdoi
10.1212/wnl.57.10.1763subject
Has Abstractpub_date
2001-11-27 00:00:00pages
1763-6issue
10eissn
0028-3878issn
1526-632Xjournal_volume
57pub_type
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