Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection.

Abstract:

:Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subacute encephalitis was mainly distributed in the frontal (58%) and temporal (69%) lobes, basal ganglia (77%), amygdala (80%), and hippocampus (64%). Ten (37%) with moderate or severe subacute encephalitis were demented; 82% with mild subacute encephalitis had no recognized neurologic disorder. Human T-lymphotropic virus type III (HTLV-III) was isolated from neural tissue or CSF in 11 of 13 patients, 10 with subacute encephalitis, and 1 without CNS lesions. We conclude that subacute encephalitis is common in AIDS patients and is most likely caused by CNS infection with HTLV-III.

journal_name

Neurology

journal_title

Neurology

authors

de la Monte SM,Ho DD,Schooley RT,Hirsch MS,Richardson EP Jr

doi

10.1212/wnl.37.4.562

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

562-9

issue

4

eissn

0028-3878

issn

1526-632X

journal_volume

37

pub_type

杂志文章
  • Cerebellar control of fixation eye movements.

    abstract::Human subjects normally have miniature eye movements during tasks that require steady visual fixation. These eye movements were compared in 12 control subjects and 4 patients with degenerative cerebellar disorders. Slow drifts, small fixation saccades, square waves, saccadic oscillations, flutter, and vertical nystagm...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.1.31

    authors: Hotson JR

    更新日期:1982-01-01 00:00:00

  • Alteration of calcium transport in Duchenne erythrocytes.

    abstract::Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.11.1236

    authors: Mollman JE,Cardenas JC,Pleasure DE

    更新日期:1980-11-01 00:00:00

  • Coexistence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration: differential effects of treatment.

    abstract::A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.10.1682

    authors: Blumenfeld AM,Recht LD,Chad DA,DeGirolami U,Griffin T,Jaeckle KA

    更新日期:1991-10-01 00:00:00

  • Severe dysarthria with right hemisphere stroke.

    abstract::Ten patients are presented with severe dysarthria from a right hemisphere stroke, 4 with autopsies, emphasizing that this lesion alone is compatible with severely slurred speech. Most had oropharyngeal weakness; the accompanying hemiparesis was of variable severity. Superficial or deep infarctions were responsible, th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.6.1061

    authors: Ropper AH

    更新日期:1987-06-01 00:00:00

  • Absence of genetic linkage of Charcot-Marie-Tooth disease (HMSN Ia) with chromosome 1 gene markers.

    abstract::We previously reported a large Charcot-Marie-Tooth family not linked to the Duffy blood group marker, supporting the existence of genetic heterogeneity in this neuropathy. In order to investigate the possibility of another disease locus on chromosome 1, we analyzed this family further, using DNA polymorphisms of 6 gen...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.6.844

    authors: Raeymaekers P,De Jonghe P,Backhovens H,Wehnert A,De Winter G,Swerts L,Gheuens J,Martin JJ,Vandenberghe A,Van Broeckhoven C

    更新日期:1989-06-01 00:00:00

  • Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen.

    abstract:OBJECTIVE:To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine. METHODS:Women with regular menstrual cycles, who were not using hormonal contrace...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000233888.18228.19

    authors: MacGregor EA,Frith A,Ellis J,Aspinall L,Hackshaw A

    更新日期:2006-12-26 00:00:00

  • A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia.

    abstract::We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 develo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.4.966

    authors: Skoog I,Wallin A,Fredman P,Hesse C,Aevarsson O,Karlsson I,Gottfries CG,Blennow K

    更新日期:1998-04-01 00:00:00

  • Chiasmal apoplexy: hemorrhage from a cryptic vascular malformation in the optic chiasm.

    abstract::We describe three patients with acute chiasmal visual field loss caused by hemorrhage within an intrachiasmal arteriovenous malformation. One patient had five episodes; vision improved three times without treatment and twice after surgical decompression. Surgical intervention restored vision in two of the three patien...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.8.1007

    authors: Lavin PJ,McCrary JA 3rd,Roessmann U,Ellenberger C Jr

    更新日期:1984-08-01 00:00:00

  • Reactivity with the peripheral myelin glycoprotein P0 in serum from patients with monoclonal IgM gammopathy and polyneuropathy.

    abstract::The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.8.1266

    authors: Bollensen E,Steck AJ,Schachner M

    更新日期:1988-08-01 00:00:00

  • Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.

    abstract::Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection a...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.45.12_suppl_8.s73

    authors: Whitley RJ

    更新日期:1995-12-01 00:00:00

  • A novel mitochondrial tRNAPhe mutation causes MERRF syndrome.

    abstract::A woman with typical features of myoclonic epilepsy with ragged red fibers (MERRF) had a novel heteroplasmic mutation (G611A) in the mitochondrial DNA tRNA phenylalanine gene. The mutation was heteroplasmic (91%) in muscle but undetectable in accessible tissues from the patient and her maternal relatives. Single-fiber...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000127608.48406.f1

    authors: Mancuso M,Filosto M,Mootha VK,Rocchi A,Pistolesi S,Murri L,DiMauro S,Siciliano G

    更新日期:2004-06-08 00:00:00

  • Multiple sclerosis and childhood infections.

    abstract::Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.10.1386

    authors: Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

    更新日期:1986-10-01 00:00:00

  • Parkinson's disease in a nationwide twin cohort.

    abstract::The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.8.1217

    authors: Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

    更新日期:1988-08-01 00:00:00

  • Epilepsy after brain infection in adults: A register-based population-wide study.

    abstract:OBJECTIVE:To describe risk and risk factors of epilepsy after hospitalization for brain infection in adults in Sweden. METHODS:This was a matched retrospective cohort study based on the comprehensive National Patient and Cause of Death Registers. All individuals age >18 without prior epilepsy who received inpatient ca...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000010954

    authors: Zelano J,Westman G

    更新日期:2020-12-15 00:00:00

  • Recovery after spinal cord infarcts: long-term outcome in 115 patients.

    abstract:OBJECTIVE:To investigate the long-term outcome of patients with spinal cord infarct (SCI) and identify prognostic predictors. METHODS:We reviewed 115 patients with SCI treated between 1990 and 2007. Severity of impairment was defined using the American Spinal Injury Association (ASIA) scoring. Functional outcome endpo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31823efc93

    authors: Robertson CE,Brown RD Jr,Wijdicks EF,Rabinstein AA

    更新日期:2012-01-10 00:00:00

  • Saccades in children with spina bifida and Chiari type II malformation.

    abstract:BACKGROUND:Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida. OBJECTIVE:To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements. METHODS:Saccade...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000166034.71337.5E

    authors: Salman MS,Sharpe JA,Eizenman M,Lillakas L,To T,Westall C,Steinbach MJ,Dennis M

    更新日期:2005-06-28 00:00:00

  • Saccadic duration and intrasaccadic fatigue in myasthenic and nonmyasthenic ocular palsies.

    abstract::We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.11.2065

    authors: Barton JJ,Jama A,Sharpe JA

    更新日期:1995-11-01 00:00:00

  • Mapping brain recovery after concussion: From acute injury to 1 year after medical clearance.

    abstract:OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008523

    authors: Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

    更新日期:2019-11-19 00:00:00

  • Lapse of consciousness and automatisms in temporal lobe epilepsy: a videotape analysis.

    abstract::Videotape analysis of 76 attacks in 14 epileptics showed two electro-clinical types of psychomotor attacks. The first and most common type had three clinical phases, consisting of an initial motionless stare, stereotyped movements, and reactive automatisms during impaired consciousness. The second and less common type...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.2.144

    authors: Escueta AV,Kunze U,Waddell G,Boxley J,Nadel A

    更新日期:1977-02-01 00:00:00

  • Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy.

    abstract:OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.2.166

    authors: Kobayashi E,Lopes-Cendes I,Guerreiro CA,Sousa SC,Guerreiro MM,Cendes F

    更新日期:2001-01-23 00:00:00

  • The acoustic startle reflex in ischemic stroke.

    abstract::The authors recorded the acoustic startle response in 32 patients with stroke, 6 patients with incomplete cervical cord lesions, and 26 controls. Increased startle occurred in about one quarter of both stroke and spinal cord injury patients. The response in biceps demonstrated the greatest deviation from normal, with ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000101711.48946.35

    authors: Jankelowitz SK,Colebatch JG

    更新日期:2004-01-13 00:00:00

  • Chronic headache: New advances in treatment strategies.

    abstract::Chronic daily headache (CDH) affects approximately 4 to 5% of the population and encompasses a number of different diagnoses, including transformed migraine, chronic tension-type headache (TTH), new-onset daily persistent headache, and hemicrania continua. Although the pathophysiology of CDH is still poorly understood...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.59.5_suppl_2.s8

    authors: Lake AE 3rd,Saper JR

    更新日期:2002-09-10 00:00:00

  • Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest.

    abstract:OBJECTIVE:To assess the relationship between CSF creatine kinase BB isoenzyme activity (CSF CKBB) and neurologic outcome after cardiac arrest in clinical practice. BACKGROUND:CSF CKBB reflects the extent of brain damage following cardiac arrest. METHODS:To help with prognosis, treating physicians ordered CSF CKBB tes...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.2.352

    authors: Tirschwell DL,Longstreth WT Jr,Rauch-Matthews ME,Chandler WL,Rothstein T,Wray L,Eng LJ,Fine J,Copass MK

    更新日期:1997-02-01 00:00:00

  • Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease.

    abstract:OBJECTIVE:To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (ran...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000256697.20968.d7

    authors: Devanand DP,Pradhaban G,Liu X,Khandji A,De Santi S,Segal S,Rusinek H,Pelton GH,Honig LS,Mayeux R,Stern Y,Tabert MH,de Leon MJ

    更新日期:2007-03-13 00:00:00

  • Age of onset, sex, and cardiomyopathy as predictors of disability and survival in Friedreich's disease: a retrospective study on 119 patients.

    abstract::We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.5.1260

    authors: De Michele G,Perrone F,Filla A,Mirante E,Giordano M,De Placido S,Campanella G

    更新日期:1996-11-01 00:00:00

  • Hemispatial and directional performance biases in motor neglect.

    abstract::Motivationally responsive motor deficits may occur in isolation or as part of more general neglect syndromes. We describe three patients with two discrete syndromes of isolated motor neglect, differentiated primarily by their performance in motor tasks enacted within or toward the contralesional hemispace. The lesions...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.3.525

    authors: Simon ES,Hegarty AM,Mehler MF

    更新日期:1995-03-01 00:00:00

  • Differential contribution of current and cumulative indices of lead dose to neuropsychological performance by age.

    abstract::We examined measures of lead dose that reflect intensity of exposure and cumulative exposure for differential association with neuropsychological functional domains and with neuropsychological performance by age. Eighty active lead smelter workers assessed for verbal memory and visuomotoric skills had a mean (range) a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.3.639

    authors: Bleecker ML,Lindgren KN,Ford DP

    更新日期:1997-03-01 00:00:00

  • Incidence of dominant spinocerebellar and Friedreich triplet repeats among 361 ataxia families.

    abstract:OBJECTIVE:To determine the incidence of spinocerebellar ataxia (SCA) types 1, 2, 3, 6, and 7 and Friedreich's ataxia (FA) among a large panel of ataxia families. BACKGROUND:The ataxias are a clinically and genetically heterogeneous group of neurodegenerative diseases that variably affect the cerebellum, brainstem, and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.51.6.1666

    authors: Moseley ML,Benzow KA,Schut LJ,Bird TD,Gomez CM,Barkhaus PE,Blindauer KA,Labuda M,Pandolfo M,Koob MD,Ranum LP

    更新日期:1998-12-01 00:00:00

  • Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications.

    abstract:OBJECTIVE:To characterize presenting symptomatology in patients with semantic dementia (SD) and to investigate whether left and right temporal variants of the disease have distinct behavioral and cognitive profiles. METHODS:Retrospective examination of case notes was performed in 47 consecutive referrals of patients w...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000091868.28557.b8

    authors: Thompson SA,Patterson K,Hodges JR

    更新日期:2003-11-11 00:00:00

  • Effect of rebleeding on the course and incidence of vasospasm after subarachnoid hemorrhage.

    abstract:OBJECTIVE:Rebleeding of an aneurysm is a leading cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Whereas numerous studies have demonstrated the risk factors associated with rebleeding, few data on complications of rebleeding, including its effect on the development of delayed cerebral ischemia (DC...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31823ed0a4

    authors: Lord AS,Fernandez L,Schmidt JM,Mayer SA,Claassen J,Lee K,Connolly ES,Badjatia N

    更新日期:2012-01-03 00:00:00