Abstract:
OBJECTIVE:To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine. METHODS:Women with regular menstrual cycles, who were not using hormonal contraception or treatments and who experienced between one and four migraine attacks per month, one of which regularly occurred on or between days 1 +/- 2 of menstruation, were studied for three cycles. Women used a fertility monitor to identify ovulation, conducting a test each day as requested by the monitor, using a sample of early morning urine. Urine samples were collected daily for assay of estrone-3-glucuronide, pregnanediol 3-glucuronide, follicle-stimulating hormone, and luteinizing hormone. All women kept a daily migraine diary and continued their usual treatment for migraine. RESULTS:Of 40 women recruited, data from 38 women were available for analysis. Compared with the expected number of attacks, there was a significantly higher number of migraine attacks during the late luteal/early follicular phase of falling estrogen and lower number of attacks during rising phases of estrogen. CONCLUSION:These findings confirm a relationship between migraine and changing levels of estrogen, supporting the hypothesis of perimenstrual but not postovulatory estrogen "withdrawal" migraine. In addition, rising levels of estrogen appear to offer some protection against migraine.
journal_name
Neurologyjournal_title
Neurologyauthors
MacGregor EA,Frith A,Ellis J,Aspinall L,Hackshaw Adoi
10.1212/01.wnl.0000233888.18228.19subject
Has Abstractpub_date
2006-12-26 00:00:00pages
2154-8issue
12eissn
0028-3878issn
1526-632Xpii
01.wnl.0000233888.18228.19journal_volume
67pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To assess alterations in brain metabolites of patients with Pelizaeus-Merzbacher disease (PMD) with the proteolipid protein gene 1 (PLP1) duplications using quantitative proton MRS. METHODS:Five unrelated male Japanese patients with PMD with PLP1 duplications were analyzed using automated proton brain examin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.237
更新日期:2002-01-22 00:00:00
abstract::The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000208442.07548.71
更新日期:2006-04-25 00:00:00
abstract::Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Maintenance doses of 3 to 4 mg per kilogram of both agents will maintain therapeutic levels. Phenytoin is, however, not pred...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.9.1107
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To correlate muscle biopsy findings with prebiopsy and postbiopsy clinical course and response to therapy in polymyositis (PM) and sporadic inclusion body myositis (IBM). BACKGROUND:Existence of pure PM has recently been questioned; subsequently, the definition and criteria for diagnosing PM were debated. M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277527.69388.fe
更新日期:2008-02-05 00:00:00
abstract::We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.253
更新日期:1991-02-01 00:00:00
abstract::Orthostatic hypotension is a fall in blood pressure on standing that causes symptoms of dizziness, visual changes, and discomfort in the head and neck. The goal of treatment is the improvement of the patient's functional capacity, rather than a target blood pressure. For treatment to be successful, it must be individu...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1995-04-01 00:00:00
abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277455.08067.9c
更新日期:2007-10-02 00:00:00
abstract:OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008844
更新日期:2020-04-28 00:00:00
abstract:OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.8.1794
更新日期:1999-11-10 00:00:00
abstract::The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.58.11.1680
更新日期:2002-06-11 00:00:00
abstract::The clinical and genetic features of three non-Portuguese and non-Japanese patients with aprataxin gene mutations are reported. Patient 1 came from Italy and presented with typical ataxia with ocular motor apraxia (OMA). She was homozygous for the W279X nonsense mutation, which is associated with the Portuguese foundi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000048562.88536.a4
更新日期:2003-03-11 00:00:00
abstract::A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.12.1157
更新日期:1977-12-01 00:00:00
abstract:OBJECTIVE:Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in the general population, we sought to assess prodromal PD (pPD) probability and relate it to detailed cognitive performance in a community cohort. METHODS:In a population-based cohort of 1,629 dementia-free and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007453
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002004
更新日期:2015-10-06 00:00:00
abstract::The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065885.15875.0d
更新日期:2003-04-22 00:00:00
abstract::To gain insight into the historical features relevant to the diagnosis of cardiac embolic strokes, we studied the 1,290 patients with cerebral infarcts in the NINCDS Stroke Data Bank. Based solely on the presence of cardiac sources of embolism, we divided the patients into groups of high (n = 250), medium (n = 166), a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.2.281
更新日期:1990-02-01 00:00:00
abstract::Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1417
更新日期:1988-09-01 00:00:00
abstract::E.C. Seguin was one of the early, influential 19th-century neurologists who participated in the development of neurology as a specialty in the United States. Born in France, but raised from early childhood in the United States, Seguin published widely, developed a high-profile New York City practice, and was named Cli...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e3182904f55
更新日期:2013-04-30 00:00:00
abstract::In the wake of dramatic economic success during the past 2 decades, the specialized field of neurology has undergone a significant transformation in China. With an increase in life expectancy, the problems of aging and cognition have grown. Lifestyle alterations have been associated with an epidemiologic transition bo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823a0ed3
更新日期:2011-11-29 00:00:00
abstract:BACKGROUND:In polyneuropathy associated with immunoglobulin M (IgM) monoclonal gammopathy, antibodies to myelin-associated glycoprotein (MAG), sulfoglucuronyl paragloboside (SGPG), and sulfatide have been associated with specific clinical and electrophysiologic features. However, it is not known whether the results of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.2.228
更新日期:2001-01-23 00:00:00
abstract:OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000287
更新日期:2014-04-08 00:00:00
abstract::Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.419
更新日期:1987-03-01 00:00:00
abstract::A number of unresolved issues complicate the effective management of patients with Parkinson's disease (PD). Chief among these is the role of neuroprotective versus symptomatic pharmacologic interventions. Until the etiology of PD is further defined, consensus on appropriate management of this illness is unlikely. Cli...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.49.1_suppl_1.s2
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004425
更新日期:2017-09-26 00:00:00
abstract::To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1157
更新日期:1979-08-01 00:00:00
abstract:OBJECTIVE:To determine the role of circulating microvesicles (MV) on long-term cardiovascular outcomes after stroke, we measured them in patients with first-ever stroke with a 3-year follow-up. METHODS:In the Prospective Cohort With Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were foll...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011223
更新日期:2020-11-12 00:00:00
abstract::In 1810, two British ships, HMS Triumph and HMS Phipps, salvaged a large load of elemental mercury from a wrecked Spanish vessel near Cadiz, Spain. The bladders containing the mercury soon ruptured. The element spread about the ships in liquid and vapor forms. The sailors presented with neurologic compromises: tremor,...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/01.wnl.0000118789.33171.47
更新日期:2004-03-23 00:00:00
abstract::Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000052823.29467.a0
更新日期:2003-04-08 00:00:00
abstract::We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.3.796
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000257818.16952.62
更新日期:2007-03-27 00:00:00