Abstract:
:The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.
journal_name
Neurologyjournal_title
Neurologyauthors
Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss ALdoi
10.1212/wnl.56.7.972subject
Has Abstractpub_date
2001-04-10 00:00:00pages
972-4issue
7eissn
0028-3878issn
1526-632Xjournal_volume
56pub_type
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