Abstract:
:The urinary excretion of some important phenylethylamines, catecholamines, their metabolites, amphetamine, and methamphetamine were measured in parkinsonian patients on Sinemet (L-dopa plus carbidopa, a peripheral dopadecarboxylase inhibitor) and depressed patients after chronic (-) deprenyl treatment. Deprenyl was efficiently metabolized to amphetamine and methamphetamine. It increased the excretion of phenylethylamine and of m- and p-tyramine, and reduced the output of norepinephrine metabolites, but failed to alter the excretion of dopamine-deaminated metabolites. These changes were attributed more to amphetamine and methamphetamine than to inhibition of monoamine oxidase type B. Sinemet treatment alone increased the excretion of dopamine, 3-methoxytyramine, and their respective deaminated metabolites, 3, 4-dihydroxyphenylacetic acid and homovanillic acid. It is concluded that conversion of deprenyl to amphetamine and methamphetamine may contribute to some of the therapeutic benefits of deprenyl.
journal_name
Neurologyjournal_title
Neurologyauthors
Karoum F,Chuang LW,Eisler T,Calne DB,Liebowitz MR,Quitkin FM,Klein DF,Wyatt RJdoi
10.1212/wnl.32.5.503subject
Has Abstractpub_date
1982-05-01 00:00:00pages
503-9issue
5eissn
0028-3878issn
1526-632Xjournal_volume
32pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Episodic paroxysmal hemicrania (EPH) is a rare disorder characterized by discrete bouts of hemicranial headache separated by headache-free remissions. Although EPH resembles episodic cluster headache in the location and quality of pain as well as the pattern of associated autonomic features, it is distinguished by the...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.42.5.964
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS:A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were en...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e318271f76a
更新日期:2012-10-30 00:00:00
abstract:OBJECTIVE:To examine the influence of birthdays on the onset and course of vascular events such as stroke, TIA, and acute myocardial infarction (AMI). METHODS:This population-based study included all emergency department (ED) admissions due to ischemic stroke, TIA, or AMI from April 2002 to March 2004 in Ontario, Cana...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000217915.06544.aa
更新日期:2006-07-25 00:00:00
abstract::An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000242728.26433.12
更新日期:2006-11-14 00:00:00
abstract::A 48-year-old man presented with progressive spastic paraparesis and diffuse white matter involvement on neuroimaging that suggested a primary demyelinating disease. Brain biopsy 3 years after onset of symptoms demonstrated idiopathic granulomatous angiitis. In patients with MRI features of diffuse white matter diseas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1696
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000148649.17706.D9
更新日期:2005-01-11 00:00:00
abstract:OBJECTIVE:To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms. METHODS:A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan. RESULTS:A total of 2,612 Marines (median age 22 yea...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004616
更新日期:2017-11-07 00:00:00
abstract::The authors evaluated how history of concussion affects symptom reporting prior to and after sustaining a concussion. At baseline, athletes with a positive concussion history reported more current symptomatology than athletes who had never been concussed. At 2 hours postinjury, concussed athletes with a history of pre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142088.32204.82
更新日期:2004-10-26 00:00:00
abstract::Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relaps...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000095425.84407.39
更新日期:2003-11-25 00:00:00
abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1769
更新日期:1985-12-01 00:00:00
abstract::We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease (AD) with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1477
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD). METHODS:We analyzed 201 consecutive patients with acute infarcts withi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824c4699
更新日期:2012-03-20 00:00:00
abstract::Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.46.3.641
更新日期:1996-03-01 00:00:00
abstract::Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.510
更新日期:1979-04-01 00:00:00
abstract::Behavioral psychophysical techniques were used to obtain strength-duration curves for the ulnar nerve at both threshold and suprathreshold levels. The functions well match those obtained with electrophysiologic procedures, but overcome many of the difficulities associated with traditional electrodiagnosis. An alternat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.4.339
更新日期:1975-04-01 00:00:00
abstract::Children with epilepsy have more behavioral and cognitive problems than children with other chronic illnesses and children in the general population. Risk factors are multiple, probably involving a combination of neurological, seizure, family, and child variables. Problems with attention and symptoms of depression occ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Endovascular therapy for acute ischemic stroke continues to evolve to improve both efficacy and safety. In the late 1990 s, intra-arterial chemical thrombolysis with prourokinase was shown to be effective in achieving partial recanalization and improving clinical outcome, in comparison with intra-arterial heparin admi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182697e9e
更新日期:2012-09-25 00:00:00
abstract::About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.2.211
更新日期:1983-02-01 00:00:00
abstract::Diffusion-weighted MRI (DWI) was used in three patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD) to provide a rapid noninvasive way to make this sometimes confusing diagnosis. DWI prompted the diagnosis of CJD at an early stage and appears to be particularly useful for monitoring the progression of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.1.205
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000323811.42080.a4
更新日期:2008-11-18 00:00:00
abstract:OBJECTIVE:To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated with immune checkpoint inhibitor (ICI) cancer immunotherapy. METHODS:In this retrospective descriptive study, 63 patients with ICI-related neurologic autoimmunity were included: 39 seen at the Mayo Clini...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010632
更新日期:2020-10-27 00:00:00
abstract::We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.59.1.123
更新日期:2002-07-09 00:00:00
abstract:OBJECTIVE:To analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings. METHODS:Data collection included comprehensive clinical investigation, study of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005346
更新日期:2018-04-24 00:00:00
abstract::We performed a retrospective study to characterize the type, frequency, and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia (B-CLL). We reviewed 962 total charts with a median follow-up time of 57.5 months. There were 109 cases (11.3%) of neurologic complications, including 69 c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.407
更新日期:1997-02-01 00:00:00
abstract::Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of toxic oxygen metabolites. Corticosteroids are frequently and effectively used to ameliorate MS exacerbations, despite inadeq...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.297
更新日期:1991-02-01 00:00:00
abstract::Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.6.1205
更新日期:1995-06-01 00:00:00
abstract::We performed proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with motor neuron disease (MND) to evaluate the distribution and extent of cortical neuron damage or loss as reflected by decreased N-acetyl (NA) to creatine (Cr) resonance intensity ratios. We examined premotor (superior frontal gyrus)...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.44.10.1933
更新日期:1994-10-01 00:00:00
abstract::Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.806
更新日期:1983-06-01 00:00:00
abstract::Juvenile myoclonic epilepsy (JME) is a distinct subform of idiopathic generalized epilepsy of adolescence. Linkage studies with Bf and serologic HLA markers in families of JME patients have shown a tight linkage on chromosome 6. We present a linkage analysis with HLA-DQ restriction fragment length polymorphisms on mor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1651
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Metals are suspected of being involved in the pathogenesis of various neurologic diseases. We previously found a complex imbalance in serum chemical elements and oxidative status in patients with clinically definite multiple sclerosis (CDMS). OBJECTIVE:To understand whether this imbalance affects people wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820af7de
更新日期:2011-02-08 00:00:00