Abstract:
:Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irregularity of the margins and erosion of the adjacent inner table of the skull. Oligodendrogliomas often enlarge slowly and may cause seizures years before they produce focal neurologic signs. CT of all children with seizures not responsive to anticonvulsant medication and focal clinical or EEG abnormalities will hasten diagnosis of slowly growing intracranial mass lesions.
journal_name
Neurologyjournal_title
Neurologyauthors
Varma RR,Crumrine PK,Bergman I,Latchaw RE,Price RA,Vries J,Painter MJdoi
10.1212/wnl.33.6.806subject
Has Abstractpub_date
1983-06-01 00:00:00pages
806-8issue
6eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180517.70572.37
更新日期:2005-10-25 00:00:00
abstract:OBJECTIVE:To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). METHODS:Forty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006157
更新日期:2018-09-11 00:00:00
abstract:OBJECTIVE:To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region. DESIGN:A family history questionnaire was used to obtain information on all first-degree relatives ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.155
更新日期:1996-07-01 00:00:00
abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract:OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000318294.36223.69
更新日期:2008-08-19 00:00:00
abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The app...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.27
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS:We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Al...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002922
更新日期:2016-08-02 00:00:00
abstract::Phenotypic heterogeneity of sporadic Creutzfeldt-Jakob disease (CJD) has been linked to biochemically distinct types of the protease-resistant form of the prion protein (type 1 and type 2 PrP(Sc)). We investigated 14 cases of sporadic CJD and found that both type 1 and type 2 PrP(Sc) coexisted in 5 subjects. The disti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2173
更新日期:1999-12-10 00:00:00
abstract::We examined measures of lead dose that reflect intensity of exposure and cumulative exposure for differential association with neuropsychological functional domains and with neuropsychological performance by age. Eighty active lead smelter workers assessed for verbal memory and visuomotoric skills had a mean (range) a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.3.639
更新日期:1997-03-01 00:00:00
abstract::A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000035533.86833.28
更新日期:2002-11-26 00:00:00
abstract::We evaluated the accuracy and interobserver variability of selected ictal and postictal behavioral changes. Three observers, blinded to clinical history, EEG, and side of surgical resection, analyzed videotapes of 166 seizures in 38 patients, looking for lateralizing signs. Twenty-seven patients with temporal lobe res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2519
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Previously, hyperoxia and blood volume increase were reported in the red nucleus and substantia nigra during spontaneous migraine with aura. OBJECTIVE:To further understand the pathophysiologic role of these centers, activation of brainstem structures was investigated in patients with visually triggered mig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.1.72
更新日期:2002-07-09 00:00:00
abstract:OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c33afb
更新日期:2009-11-24 00:00:00
abstract:OBJECTIVE:To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series. METHODS:We performed medical record review of 184 patients who met clinical and electrodiagnostic criteria for OT from 1976 to 2013 at the Mayo Clinic. Demographic, clinical, electr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002328
更新日期:2016-02-02 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis that poses challenges with respect to diagnosis and monitoring of disease progression. OBJECTIVES:To identify a biomarker panel that elucidates ALS disease pathogenesis, distinguishes patients with A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000333251.36681.a5
更新日期:2009-01-06 00:00:00
abstract::We administered a battery of cognitive tests to 41 recently diagnosed Parkinson patients and 41 controls to assess the early neuropsychological changes associated with Parkinson's disease (PD). Parkinson subjects did as well as controls on tasks assessing attention and select language and visuospatial measures. Howeve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.4.557
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. MET...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.2.198
更新日期:2000-07-25 00:00:00
abstract:OBJECTIVE:To determine the association between traumatic brain injury (TBI) and any clinically diagnosed α-synucleinopathy including Parkinson disease (PD), dementia with Lewy bodies (DLB), PD dementia (PDD), and multiple system atrophy (MSA). METHODS:Using the medical records-linkage system of the Rochester Epidemiol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008995
更新日期:2020-02-25 00:00:00
abstract::Lymphocytic meningoradiculitis (Bannwarth's syndrome) is a radicular neuralgia associated with a chronic lymphocytic pleocytosis in cerebrospinal fluid and frequently with unilateral or bilateral peripheral facial weakness. Most reported cases have occurred during the summer among adults living in central Europe. Lymp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1476
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVE:To describe the detection frequency and clinical associations of immunoglobulin G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channels. METHODS:Specimens from 20 patients evaluated on a service basis by tissue-based immunofluorescence yielded a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000991
更新日期:2014-11-11 00:00:00
abstract::Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.419
更新日期:1987-03-01 00:00:00
abstract::The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.50.1.136
更新日期:1998-01-01 00:00:00
abstract::We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.6.891
更新日期:1990-06-01 00:00:00
abstract::We prospectively evaluated 84 consecutive adult patients with chronic liver disease before and after liver transplantation to define the type and frequency of post-transplant neurologic complications, and to assess possible pretransplant and operative variables associated with in-hospital CNS complications. There were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.7.1226
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. METHODS:Thirty-one patients with head injury who had completed the Acute Neuro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.10.1536
更新日期:2000-11-28 00:00:00
abstract:BACKGROUND:Primary angiitis of the CNS (PACNS) is a diagnostically challenging disorder. In patients whose diagnosis is ascertained solely by cerebral angiography without histologic verification, a benign monophasic clinical course with favorable response to a brief course of immunosuppressive therapy is often reported...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.1.183
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318253d62f
更新日期:2012-05-01 00:00:00
abstract::We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1115
更新日期:1989-08-01 00:00:00
abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.726
更新日期:1980-07-01 00:00:00