Donepezil and flight simulator performance: effects on retention of complex skills.

Abstract:

:We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

journal_name

Neurology

journal_title

Neurology

authors

Yesavage JA,Mumenthaler MS,Taylor JL,Friedman L,O'Hara R,Sheikh J,Tinklenberg J,Whitehouse PJ

doi

10.1212/wnl.59.1.123

subject

Has Abstract

pub_date

2002-07-09 00:00:00

pages

123-5

issue

1

eissn

0028-3878

issn

1526-632X

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验
  • Transient drug-induced abolition of BAEPs in coma.

    abstract::Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.9.1487

    authors: García-Larrea L,Artru F,Bertrand O,Pernier J,Mauguière F

    更新日期:1988-09-01 00:00:00

  • Effect of insurance status on postacute care among working age stroke survivors.

    abstract:OBJECTIVE:Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working age stroke survivors. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182563bf5

    authors: Skolarus LE,Meurer WJ,Burke JF,Prvu Bettger J,Lisabeth LD

    更新日期:2012-05-15 00:00:00

  • Multifocal motor neuropathy with and without conduction block: a single entity?

    abstract:OBJECTIVE:To assess if multifocal motor neuropathy (MMN) with and MMN without conduction block (CB) are similar or distinct diseases. METHODS:The authors reviewed the clinical features and responses to IV immunoglobulin (IVIg) treatment of patients with MMN with and without CB at diagnosis, after 4 years of follow-up ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000234063.51897.20

    authors: Delmont E,Azulay JP,Giorgi R,Attarian S,Verschueren A,Uzenot D,Pouget J

    更新日期:2006-08-22 00:00:00

  • Interphysician agreement in the diagnosis of subtypes of acute ischemic stroke: implications for clinical trials. The TOAST Investigators.

    abstract::To test interphysician agreement on the diagnosis of subtype of ischemic stroke, we sent subtype definitions and 18 case summaries (clinical features and pertinent laboratory data) to 24 neurologists who have a special interest in stroke, and asked them to determine the most likely subtype diagnosis. The overall agree...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.5.1021

    authors: Gordon DL,Bendixen BH,Adams HP Jr,Clarke W,Kappelle LJ,Woolson RF

    更新日期:1993-05-01 00:00:00

  • Ischemic stroke subtypes among Mexican Americans and non-Hispanic whites: the BASIC Project.

    abstract::Ischemic stroke subtype distribution was compared between Mexican Americans (MAs) and non-Hispanic whites (NHWs) in a community-based stroke surveillance study in Nueces County, TX. There was no difference in the distribution of stroke subtype by ethnicity (p = 0.19). There was a similar proportion of small-vessel and...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000133212.99040.07

    authors: Uchino K,Risser JM,Smith MA,Moyé LA,Morgenstern LB

    更新日期:2004-08-10 00:00:00

  • Magnetic resonance imaging in pathologically proven Hallervorden-Spatz disease.

    abstract::We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.3.440

    authors: Schaffert DA,Johnsen SD,Johnson PC,Drayer BP

    更新日期:1989-03-01 00:00:00

  • Nearly ubiquitous tissue distribution of the scrapie agent precursor protein.

    abstract::The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.1.149

    authors: Bendheim PE,Brown HR,Rudelli RD,Scala LJ,Goller NL,Wen GY,Kascsak RJ,Cashman NR,Bolton DC

    更新日期:1992-01-01 00:00:00

  • 18F-FDG-PET correlates of cognitive impairment in ALS.

    abstract:OBJECTIVE:To identify the metabolic signature of the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). METHODS:A total of 170 ALS cases consecutively enrolled at the ALS Center of Turin underwent brain 18F-FDG-PET and were classified as ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002242

    authors: Canosa A,Pagani M,Cistaro A,Montuschi A,Iazzolino B,Fania P,Cammarosano S,Ilardi A,Moglia C,Calvo A,Chiò A

    更新日期:2016-01-05 00:00:00

  • Delayed psychosis after right temporoparietal stroke or trauma: relation to epilepsy.

    abstract::We observed acute onset of delayed psychosis in 8 patients 1 month to 11 years after right temporoparietooccipital (TPO) stroke or trauma. The psychotic disorder included hallucinations and, in some patients delusions and agitation. All patients had spatioconstructional difficulties. None had an earlier psychiatric di...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.3.267

    authors: Levine DN,Finklestein S

    更新日期:1982-03-01 00:00:00

  • Vascular lesions in Chinese patients with transient ischemic attacks.

    abstract::We studied 96 Chinese patients with TIAs using transcranial Doppler and duplex ultrasonography. We found intracranial stenosis or occlusion in 51% of cases and extracranial disease in 19% of cases. The most common intracranial lesion was stenosis of the terminal internal carotid artery or proximal middle cerebral arte...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.2.524

    authors: Huang YN,Gao S,Li SW,Huang Y,Li JF,Wong KS,Kay R

    更新日期:1997-02-01 00:00:00

  • CT and MRI findings among African-Americans with Alzheimer's disease, vascular dementia, and stroke without dementia.

    abstract::We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD pa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.8.1456

    authors: Charletta D,Gorelick PB,Dollear TJ,Freels S,Harris Y

    更新日期:1995-08-01 00:00:00

  • On the cause of hyporeflexia in the Holmes-Adie syndrome.

    abstract::Electrophysiologic studies were carried out on 11 patients with Holmes-Adie syndrome, 8 of whom had reduced or absent ankle jerks. Conduction velocities and evoked nerve and muscle compound action potentials in the peroneal, posterior tibial, and sural nerves were normal. The H reflex was absent (or virtually absent) ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.2.262

    authors: Miyasaki JM,Ashby P,Sharpe JA,Fletcher WA

    更新日期:1988-02-01 00:00:00

  • Atherosclerotic carotid artery disease in patients with retinal ischemic syndromes.

    abstract::The extracranial carotid systems of 105 patients with retinal ischemia were examined using B-mode ultrasonography with integrated pulsed Doppler. Sixty-four patients had amaurosis fugax (AF), 17 central retinal artery occlusions (CRAO), and 21 branch retinal artery occlusions (BRAO). The prevalence of carotid stenosis...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.6.858

    authors: Chawluk JB,Kushner MJ,Bank WJ,Silver FL,Jamieson DG,Bosley TM,Conway DJ,Cohen D,Savino PJ

    更新日期:1988-06-01 00:00:00

  • Figuring out drawing-induced epilepsy.

    abstract::Rare reflex epilepsies are a clinical curiosity but may also give insight into neurocognitive processes. The authors present a patient whose seizures were precipitated by drawing but not by writing. This dissociation complements previous reports on selective impairment of writing. EEG revealed a focus in the right fro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000200953.62141.89

    authors: Kho KH,van den Bergh WM,Spetgens WP,Leijten FS

    更新日期:2006-03-14 00:00:00

  • Dantrolene sodium and hepatic injury.

    abstract::This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.9.1427

    authors: Chan CH

    更新日期:1990-09-01 00:00:00

  • Outcome prediction in mechanically ventilated neurologic patients by junior neurointensivists.

    abstract:OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181d8197f

    authors: Finley Caulfield A,Gabler L,Lansberg MG,Eyngorn I,Mlynash M,Buckwalter MS,Venkatasubramanian C,Wijman CA

    更新日期:2010-04-06 00:00:00

  • Cognitive impairment and dementia in neurocysticercosis: a cross-sectional controlled study.

    abstract:OBJECTIVES:Neurocysticercosis (NCYST) is the most frequent CNS parasitic disease worldwide, affecting more than 50 million people. However, some of its clinical findings, such as cognitive impairment and dementia, remain poorly characterized, with no controlled studies conducted so far. We investigated the frequency an...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181d9eda6

    authors: Ciampi de Andrade D,Rodrigues CL,Abraham R,Castro LH,Livramento JA,Machado LR,Leite CC,Caramelli P

    更新日期:2010-04-20 00:00:00

  • Serum trihexyphenidyl levels in the treatment of torsion dystonia.

    abstract::Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.7.1066

    authors: Burke RE,Fahn S

    更新日期:1985-07-01 00:00:00

  • Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease.

    abstract::To elucidate the possible role of vitamin E in the pathogenesis of Parkinson's disease (PD), we compared serum levels of alpha-tocopherol (vitamin E), measured by high-performance liquid chromatography, and the vitamin E/cholesterol ratio of 42 Parkinson's disease (PD) patients using their spouses as the control group...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.5.1064

    authors: Férnandez-Calle P,Molina JA,Jiménez-Jiménez FJ,Vázquez A,Pondal M,García-Ruiz PJ,Urra DG,Domingo J,Codoceo R

    更新日期:1992-05-01 00:00:00

  • Myoclonus-dystonia: clinical and electrophysiologic pattern related to SGCE mutations.

    abstract:OBJECTIVE:To clarify the clinical and neurophysiologic spectrum of myoclonus-dystonia patients with mutations of the SGCE gene. METHODS:We prospectively studied 41 consecutive patients from 22 families with documented mutations of the SGCE gene. The patients had a standardized interview, neurologic examination, and de...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000297516.98574.c0

    authors: Roze E,Apartis E,Clot F,Dorison N,Thobois S,Guyant-Marechal L,Tranchant C,Damier P,Doummar D,Bahi-Buisson N,André-Obadia N,Maltete D,Echaniz-Laguna A,Pereon Y,Beaugendre Y,Dupont S,De Greslan T,Jedynak CP,Ponsot G,D

    更新日期:2008-03-25 00:00:00

  • A direct comparison of PET activation and electrocortical stimulation mapping for language localization.

    abstract::Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.4.1056

    authors: Bookheimer SY,Zeffiro TA,Blaxton T,Malow BA,Gaillard WD,Sato S,Kufta C,Fedio P,Theodore WH

    更新日期:1997-04-01 00:00:00

  • Declining incidence of multiple sclerosis in the Orkney Islands.

    abstract::The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.4.545

    authors: Cook SD,Cromarty JI,Tapp W,Poskanzer D,Walker JD,Dowling PC

    更新日期:1985-04-01 00:00:00

  • Basilar artery embolism. Clinical syndrome and neuroradiologic patterns in patients without permanent occlusion of the basilar artery.

    abstract::The objective of this study was to clarify the clinical and radiologic features, risk factors, and prognosis of basilar embolism without permanent basilar artery occlusion. Forty-five patients (mean age, 59 years) with basilar artery embolism participated in the study. Patients with basilar artery occlusion were exclu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.5.1346

    authors: Schwarz S,Egelhof T,Schwab S,Hacke W

    更新日期:1997-11-01 00:00:00

  • Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder.

    abstract:BACKGROUND:Idiopathic REM sleep behavior disorder (RBD) is characterized by loss of atonia during REM sleep, resulting in motor activity during dreams. Studies estimate that approximately half of patients with RBD will eventually develop Parkinson disease (PD), so RBD may be an indicator of presymptomatic PD. Several p...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000203648.80727.5b

    authors: Postuma RB,Lang AE,Massicotte-Marquez J,Montplaisir J

    更新日期:2006-03-28 00:00:00

  • Antineuronal antibodies in patients with neurologic complications of primary Sjögren's syndrome.

    abstract::Neurologic complications of both the central and peripheral nervous systems occur frequently in patients with primary Sjögren's syndrome (primary SS), but the underlying cause of these complications is unknown. We studied the presence of antineuronal antibodies in relation to neurologic complications in a consecutive ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.12.2574

    authors: Moll JW,Markusse HM,Pijnenburg JJ,Vecht CJ,Henzen-Logmans SC

    更新日期:1993-12-01 00:00:00

  • Tourette's syndrome and 'PANDAS': will the relation bear out? Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection.

    abstract::Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...

    journal_title:Neurology

    pub_type: 评论,杂志文章,评审

    doi:10.1212/wnl.50.6.1530

    authors: Kurlan R

    更新日期:1998-06-01 00:00:00

  • Covert recognition in acquired and developmental prosopagnosia.

    abstract:BACKGROUND:Some patients with prosopagnosia have covert recognition, meaning that they retain some familiarity or knowledge of facial identity of which they are not aware. OBJECTIVE:To test the hypothesis that prosopagnosic patients with right occipitotemporal lesions and impaired face perception lack covert processin...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.7.1161

    authors: Barton JJ,Cherkasova M,O'Connor M

    更新日期:2001-10-09 00:00:00

  • Electroencephalographic evaluation in Sturge-Weber syndrome.

    abstract::The most consistent electroencephalographic finding in 16 cases of Sturge-Weber syndrome was a unilateral reduction of background amplitude in the waking record. Comparable asymmetries were noted in those patients in whom sleep recording also was done. Physiologic responses (to hyperventilation and photic driving) usu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.26.7.629

    authors: Brenner RP,Sharbrough FW

    更新日期:1976-07-01 00:00:00

  • Importance of the imaging modality in decision making about carotid endarterectomy.

    abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000115097.61748.bf

    authors: Kennedy J,Quan H,Ghali WA,Feasby TE

    更新日期:2004-03-23 00:00:00

  • Migraine and the risk of cervical artery dissection: a case-control study.

    abstract::The association between migraine and cervical artery dissection (CAD) was explored in a hospital-based case-control study. Migraine was present in 49.1% (23/47) of patients with CAD and in 21% (11/52) of patients hospitalized for a cerebral ischemic event not related to a CAD (adjusted odds ratio = 3.6; 1.5 to 8.6, p ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.59.3.435

    authors: Tzourio C,Benslamia L,Guillon B,Aïdi S,Bertrand M,Berthet K,Bousser MG

    更新日期:2002-08-13 00:00:00