Serum trihexyphenidyl levels in the treatment of torsion dystonia.

abstract：:Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for eac...

journal_title：Neurology

authors： Engel J Jr,Kuhl DE,Phelps ME,Rausch R,Nuwer M

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:To characterize prospectively the cognitive profile in ALS. METHODS:Clinically definite ALS patients (11 men, 2 women), age 39.9 to 74.0 years (mean age, 54.2 +/- 9.6 years; mean disease duration, 21.1 +/- 10.5 months) underwent neuropsychologic, language, and speech testing followed by MR 1H spectroscopy (4...

journal_title：Neurology

authors： Strong MJ,Grace GM,Orange JB,Leeper HA,Menon RS,Aere C

更新日期：1999-11-10 00:00:00

abstract：OBJECTIVE:The authors investigated chronic cerebellar reorganization following unilateral cortical lesions in children and adults using PET to measure benzodiazepine receptor (BZR) binding with [11C]flumazenil (FMZ) and glucose metabolism with 2-deoxy-2[18F]fluoro-D-glucose (FDG). BACKGROUND:Crossed cerebellar diaschi...

journal_title：Neurology

authors： Niimura K,Chugani DC,Muzik O,Chugani HT

更新日期：1999-03-10 00:00:00

abstract：OBJECTIVE:To define potential pathogenic mitochondrial DNA (mtDNA) point mutations in a patient with myoclonus epilepsy with ragged-red fibers (MERRF) syndrome. BACKGROUND:MERRF syndrome is typically associated with point mutations in the mtDNA tRNALys gene. METHODS:We performed morphologic, biochemical, and genetic ...

journal_title：Neurology

authors： Arenas J,Campos Y,Bornstein B,Ribacoba R,Martín MA,Rubio JC,Santorelli FM,Zeviani M,DiMauro S,Garesse R

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial. METHODS:Participants were 164 older Catholic nuns, priests, and brothers who underwent annual clinical evaluation and brain autopsy at death. The authors quantified number and ...

journal_title：Neurology

authors： Schneider JA,Wilson RS,Cochran EJ,Bienias JL,Arnold SE,Evans DA,Bennett DA

更新日期：2003-04-08 00:00:00

abstract：OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...

journal_title：Neurology

authors： Röricht S,Meyer BU

更新日期：2000-02-22 00:00:00

abstract：:Phenotypic heterogeneity of sporadic Creutzfeldt-Jakob disease (CJD) has been linked to biochemically distinct types of the protease-resistant form of the prion protein (type 1 and type 2 PrP(Sc)). We investigated 14 cases of sporadic CJD and found that both type 1 and type 2 PrP(Sc) coexisted in 5 subjects. The disti...

journal_title：Neurology

authors： Puoti G,Giaccone G,Rossi G,Canciani B,Bugiani O,Tagliavini F

更新日期：1999-12-10 00:00:00

abstract：OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...

journal_title：Neurology

authors： Frohman EM,Zhang H,Kramer PD,Fleckenstein J,Hawker K,Racke MK,Frohman TC

更新日期：2001-09-11 00:00:00

abstract：:Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...

journal_title：Neurology

authors： Camfield PR,Metrakos K,Andermann F

更新日期：1978-06-01 00:00:00

abstract：OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...

journal_title：Neurology

authors： van der Salm SM,van Rootselaar AF,Cath DC,de Haan RJ,Koelman JH,Tijssen MA

更新日期：2017-01-10 00:00:00

abstract：OBJECTIVE:To examine the effects of natalizumab on low-contrast letter acuity as a prespecified tertiary endpoint in two randomized clinical trials and to evaluate the usefulness of low-contrast letter acuity testing as a candidate test of visual function in multiple sclerosis (MS). METHODS:AFFIRM and SENTINEL were ra...

journal_title：Neurology

authors： Balcer LJ,Galetta SL,Calabresi PA,Confavreux C,Giovannoni G,Havrdova E,Hutchinson M,Kappos L,Lublin FD,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Wajgt A,Weinstock-Guttman B,Wynn DR,Lyn

更新日期：2007-04-17 00:00:00

abstract：:The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...

journal_title：Neurology

authors： Weiner MJ,Hallett M,Funkenstein HH

更新日期：1983-06-01 00:00:00

abstract：:Anti-Leu 7 antibody reacts with determinants on a subset of natural killer (NK) cells and myelin-associated glycoprotein (MAG). In a patient patient with peripheral neuropathy and IgM autoantibodies against MAG, we found the distribution and functions of NK cells to be normal. ...

journal_title：Neurology

authors： Sriram S,Lanier L

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVE:To establish a variant of sporadic prion disease as the sporadic form of fatal familial insomnia (FFI). BACKGROUND:FFI is a recently described prion disease characterized clinically by severe sleep impairment, dysautonomia, and motor signs, and pathologically by atrophy of thalamic nuclei, especially the med...

journal_title：Neurology

authors： Parchi P,Capellari S,Chin S,Schwarz HB,Schecter NP,Butts JD,Hudkins P,Burns DK,Powers JM,Gambetti P

更新日期：1999-06-10 00:00:00

abstract：BACKGROUND:Cross-sectional studies suggest gender differences in cognitive function and risk of AD in older persons. However, longitudinal studies comparing change in cognitive function and risk of AD in men and women have had mixed results. The authors investigated gender differences in rate of decline for different c...

journal_title：Neurology

authors： Barnes LL,Wilson RS,Schneider JA,Bienias JL,Evans DA,Bennett DA

更新日期：2003-06-10 00:00:00

abstract：:Assay of anti-striated muscle antibodies (StrAb) is used as a diagnostic test for thymoma in individuals with myasthenia gravis. Unfortunately, false positive results are common, and their effect on test accuracy is magnified by the relatively low frequency of thymoma in myasthenics. We estimated the predictive values...

journal_title：Neurology

authors： Lanska DJ

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of multiple sclerosis (MS) in a longitudinal surveillance over 35 years and to estimate the prevalence rate in Saskatoon, Saskatchewan, on January 1, 2005. METHODS:A population-based registry was established in 1969, and identification of cases continued to 2005, from medical recor...

journal_title：Neurology

authors： Hader WJ,Yee IM

更新日期：2007-09-18 00:00:00

abstract：:This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...

journal_title：Neurology

authors： Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:To describe the results of a multicenter study that validated two new patient-reported measures of neurologic impairment and disability for use in MS clinical research. BACKGROUND:Self-reported data can provide a cost-effective means to assess patient functioning, and can be useful for screening patients who...

journal_title：Neurology

authors： Schwartz CE,Vollmer T,Lee H

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by immune-mediated peripheral demyelination. Although corticosteroid, IV immunoglobulin (IVIg) and plasma exchange have been established as the most effective therapeutics, subpopulations of patients show little or no response to either...

journal_title：Neurology

authors： Iijima M,Tomita M,Morozumi S,Kawagashira Y,Nakamura T,Koike H,Katsuno M,Hattori N,Tanaka F,Yamamoto M,Sobue G

更新日期：2009-10-27 00:00:00

abstract：OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...

journal_title：Neurology

authors： Kornblith E,Peltz CB,Xia F,Plassman B,Novakovic-Apopain T,Yaffe K

更新日期：2020-09-29 00:00:00

abstract：OBJECTIVE:To assess the correlation of tissue parameters estimated by quantitative magnetic resonance (MR) techniques and motor handicap in patients with hypomyelination. METHODS:Twenty-eight patients with different causes of hypomyelination (12 males, 16 females; mean age 10 years) and 61 controls (33 males, 28 femal...

journal_title：Neurology

authors： Steenweg ME,Wolf NI,van Wieringen WN,Barkhof F,van der Knaap MS,Pouwels PJ

更新日期：2016-08-23 00:00:00

abstract：:Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...

journal_title：Neurology

authors： Miller RG,Sherratt M

更新日期：1978-12-01 00:00:00

abstract：:We have discovered a new Italian pedigree with autosomal-dominant ALS. The pedigree, at present, comprises 75 members distributed in five generations. ALS was diagnosed in eight patients. The mean +/- SD age of onset of the disease was 46.8 +/- 13.5 years, with a range of 29 to 63 years. The mean +/- SD duration of th...

journal_title：Neurology

authors： Rainero I,Pinessi L,Tsuda T,Vignocchi MG,Vaula G,Calvi L,Cerrato P,Rossi B,Bergamini L,McLachlan DR

更新日期：1994-02-01 00:00:00

abstract：:Although a neuromuscular syndrome has been induced experimentally by vitamin E deficiency, a human syndrome has not yet been documented. This report describes a 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy,...

journal_title：Neurology

authors： Tomasi LG

更新日期：1979-08-01 00:00:00

abstract：OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...

journal_title：Neurology

authors： Peterlin BL,Mielke MM,Dickens AM,Chatterjee S,Dash P,Alexander G,Vieira RV,Bandaru VV,Dorskind JM,Tietjen GE,Haughey NH

更新日期：2015-10-06 00:00:00

abstract：:A 34-year-old man presented with a 30-year history of spasmodic dysphonia. He developed a speech disturbance 1 month after a closed head injury due to a fall. Sighing, coughing, and crying were normal. He had a tremor of the right hand when he drew a vertical line. His out-stretched right hand had a minimal dystonic p...

journal_title：Neurology

authors： Lee MS,Lee SB,Kim WC

更新日期：1996-09-01 00:00:00

abstract：:An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...

journal_title：Neurology

authors： Lavi E,Montone KT,Rorke LB,Kliman HJ

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...

journal_title：Neurology

authors： Ryu DW,Shon YM,Kim BS,Cho AH

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:In children with and without infantile spasms, this study determined brain volumes and cell densities in epilepsy surgery patients with tuberous sclerosis complex (TSC) and cortical dysplasia with balloon cells (CD). METHODS:We compared TSC (n = 18) and CD (n = 17) patients with normal/autopsy controls (n = ...

journal_title：Neurology

authors： Chandra PS,Salamon N,Nguyen ST,Chang JW,Huynh MN,Cepeda C,Leite JP,Neder L,Koh S,Vinters HV,Mathern GW

更新日期：2007-02-06 00:00:00