Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.

Abstract:

OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by immune-mediated peripheral demyelination. Although corticosteroid, IV immunoglobulin (IVIg) and plasma exchange have been established as the most effective therapeutics, subpopulations of patients show little or no response to either of these therapies. In this study, we examined whether particular genetic factors influence the therapeutic responsiveness of patients with CIDP. METHODS:One hundred Japanese patients categorized as responders or nonresponders to IVIg therapy participated in our study. We performed an association analysis with single nucleotide polymorphisms (SNPs) and haplotype studies between the IVIg responders and nonresponders. RESULTS:Two separate SNPs, corresponding to TAG-1 (transient axonal glycoprotein 1) and CLEC10A (C-type lectin domain family 10, member A), showed strong significant differences between responders and nonresponders. Haplotype analysis of a series of expanded SNPs, from TAG-1 or CLEC10A, showed that only TAG-1 included a significant haplotype within 1 linkage disequilibrium block, which accommodates IVIg responsiveness. Diplotype analysis of TAG-1 also supported this observation. CONCLUSIONS:Transient axonal glycoprotein 1 is a crucial molecule involved in IV immunoglobulin responsiveness in Japanese patients with chronic inflammatory demyelinating polyneuropathy.

journal_name

Neurology

journal_title

Neurology

authors

Iijima M,Tomita M,Morozumi S,Kawagashira Y,Nakamura T,Koike H,Katsuno M,Hattori N,Tanaka F,Yamamoto M,Sobue G

doi

10.1212/WNL.0b013e3181bd1139

subject

Has Abstract

pub_date

2009-10-27 00:00:00

pages

1348-52

issue

17

eissn

0028-3878

issn

1526-632X

pii

WNL.0b013e3181bd1139

journal_volume

73

pub_type

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