Abstract:
:This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs developed brain tumors. Serum samples drawn prior to and serially after tumor inoculation showed development of antibodies reactive to the tumor. All tumors were visualized with MRI. Contrast-enhanced T1-weighted imaging was the most sensitive with gadolinium producing tumor enhancement due to blood-brain barrier breakdown. Gross and microscopic autopsy findings correlated well with MRIs.
journal_name
Neurologyjournal_title
Neurologyauthors
Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jrdoi
10.1212/wnl.37.7.1235subject
Has Abstractpub_date
1987-07-01 00:00:00pages
1235-9issue
7eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
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