Magnetic resonance brain tumor imaging in canine glioma.

Abstract:

:This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs developed brain tumors. Serum samples drawn prior to and serially after tumor inoculation showed development of antibodies reactive to the tumor. All tumors were visualized with MRI. Contrast-enhanced T1-weighted imaging was the most sensitive with gadolinium producing tumor enhancement due to blood-brain barrier breakdown. Gross and microscopic autopsy findings correlated well with MRIs.

journal_name

Neurology

journal_title

Neurology

authors

Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

doi

10.1212/wnl.37.7.1235

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

1235-9

issue

7

eissn

0028-3878

issn

1526-632X

journal_volume

37

pub_type

杂志文章
  • Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis.

    abstract:OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.2.184

    authors: Fuerst D,Shah J,Kupsky WJ,Johnson R,Shah A,Hayman-Abello B,Ergh T,Poore Q,Canady A,Watson C

    更新日期:2001-07-24 00:00:00

  • The Workforce Task Force report: clinical implications for neurology.

    abstract::The American Academy of Neurology Workforce Task Force (WFTF) report predicts a future shortfall of neurologists in the United States. The WFTF data also suggest that for most states, the current demand for neurologist services already exceeds the supply, and by 2025 the demand for neurologists will be even higher. Th...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e31829d8783

    authors: Freeman WD,Vatz KA,Griggs RC,Pedley T

    更新日期:2013-07-30 00:00:00

  • Right Brain: The E-lephant in the room: One resident's challenge in transitioning to modern electronic medicine.

    abstract::The electronic medical record (EMR) is changing the landscape of medical practice in the modern age. Increasing emphasis on quality metric reporting, data-driven documentation, and timely coding and billing are pressuring institutions across the country to adopt the latest EMR technology. The impact of these systems o...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000000819

    authors: Strowd RE 3rd

    更新日期:2014-09-23 00:00:00

  • Dantrolene sodium and hepatic injury.

    abstract::This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.9.1427

    authors: Chan CH

    更新日期:1990-09-01 00:00:00

  • Oral fluoroquinolone use and risk of peripheral neuropathy: a pharmacoepidemiologic study.

    abstract:OBJECTIVE:To quantify the risk of peripheral neuropathy (PN) with oral fluoroquinolone (FQ) use. METHODS:We conducted a case-control study within a cohort of men aged 45 to 80 years in the United States followed from 2001 to 2011. Cases were defined as those with the first physician visit diagnosis of PN, polyneuropat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000846

    authors: Etminan M,Brophy JM,Samii A

    更新日期:2014-09-30 00:00:00

  • Abnormal ventilation during exercise in McArdle's syndrome: modulation by substrate availability.

    abstract::We evaluated ventilation during cycle exercise in four men lacking myophosphorylase. In submaximal exercise of similar relative intensity, ventilation was higher relative to oxygen uptake in McArdle patients than in normal men. The exercise ventilatory response returned to normal after glucose infusion, by fasting to ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.5.716

    authors: Haller RG,Lewis SF

    更新日期:1986-05-01 00:00:00

  • Diagnosis of vestibular imbalance in the blink of an eye.

    abstract:BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000141144.02666.8c

    authors: Schneider E,Glasauer S,Dieterich M,Kalla R,Brandt T

    更新日期:2004-10-12 00:00:00

  • A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group.

    abstract::Ciliary neurotrophic factor (CNTF) is a neuroactive cytokine found in Schwann cells, which appears to be released in response to nerve injury. The ALS CNTF Treatment Study (ACTS) clinical trial was a phase II-III randomized, placebo-controlled, double-blind study designed to evaluate the safety, tolerability, and effi...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.46.5.1244

    authors:

    更新日期:1996-05-01 00:00:00

  • Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy.

    abstract::Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is incre...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318294b2eb

    authors: Fujioka S,Algom AA,Murray ME,Strongosky A,Soto-Ortolaza AI,Rademakers R,Ross OA,Wszolek ZK,Dickson DW

    更新日期:2013-05-28 00:00:00

  • GABAB receptor autoantibody frequency in service serologic evaluation.

    abstract:OBJECTIVE:Small-cell lung carcinoma (SCLC) and limbic encephalitis are recognized γ-aminobutyric acid-B receptor (GABABR) autoantibody accompaniments. We sought to determine in a diagnostic serology laboratory the frequency and accompaniments (neurologic, oncologic, and serologic) of GABABR-immunoglobulin G (IgG). MET...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182a35271

    authors: Jeffery OJ,Lennon VA,Pittock SJ,Gregory JK,Britton JW,McKeon A

    更新日期:2013-09-03 00:00:00

  • TENS for the treatment of writer's cramp dystonia: a randomized, placebo-controlled study.

    abstract::Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer's cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures o...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/01.WNL.0000163851.70927.7E

    authors: Tinazzi M,Farina S,Bhatia K,Fiaschi A,Moretto G,Bertolasi L,Zarattini S,Smania N

    更新日期:2005-06-14 00:00:00

  • Electroencephalographic evaluation in Sturge-Weber syndrome.

    abstract::The most consistent electroencephalographic finding in 16 cases of Sturge-Weber syndrome was a unilateral reduction of background amplitude in the waking record. Comparable asymmetries were noted in those patients in whom sleep recording also was done. Physiologic responses (to hyperventilation and photic driving) usu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.26.7.629

    authors: Brenner RP,Sharbrough FW

    更新日期:1976-07-01 00:00:00

  • Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

    abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0b013e31829c5cfe

    authors: Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

    更新日期:2013-07-23 00:00:00

  • Hypnic headache: clinical features, pathophysiology, and treatment.

    abstract::Hypnic headache has been described in several case reports since 1981 and is regarded as an idiopathic headache disorder. In this review of 71 cases in the literature, the clinical features, neurophysiologic including polysomnographic findings, and treatment procedures are analyzed and the pathophysiology of this cond...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000046582.21771.9c

    authors: Evers S,Goadsby PJ

    更新日期:2003-03-25 00:00:00

  • Primary prevention trials in Alzheimer disease.

    abstract::Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.67.9_suppl_3.s2

    authors: Green RC,DeKosky ST

    更新日期:2006-11-14 00:00:00

  • Pharmacology of dopamine agonists in the treatment of Parkinson's disease.

    abstract::There is now increasing use of dopamine agonists as effective early monotherapy in the treatment of Parkinson's disease (PD). Dopamine agonists can induce an antiparkinsonian effect through actions on either D(1)-like or D(2)-like dopamine receptors, and the multiple receptor subtypes present in the brain may provide ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.58.suppl_1.s1

    authors: Jenner P

    更新日期:2002-02-26 00:00:00

  • Elevated cortical zinc in Alzheimer disease.

    abstract:OBJECTIVE:To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS:The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tiss...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000223644.08653.b5

    authors: Religa D,Strozyk D,Cherny RA,Volitakis I,Haroutunian V,Winblad B,Naslund J,Bush AI

    更新日期:2006-07-11 00:00:00

  • Acute late-onset encephalopathy after radiotherapy: an unusual life-threatening complication.

    abstract::Unusual late-onset complications of brain irradiation, characterized by reversible neurologic focal signs, seizures, and MRI alterations, have recently been reported and classified as stroke-like migraine attacks after radiation therapy (SMART)(1) and peri-ictal pseudoprogression (PIPG).(2.) ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182a43b1f

    authors: Di Stefano AL,Berzero G,Vitali P,Galimberti CA,Ducray F,Ceroni M,Bastianello S,Colombo AA,Simoncelli A,Brunelli MC,Giometto B,Diamanti L,Gaviani P,Salmaggi A,Silvani A,Marchioni E

    更新日期:2013-09-10 00:00:00

  • Multiple sclerosis after age 50.

    abstract::When multiple sclerosis (MS) presents late in life (after the age of 50), it frequently gives diagnostic difficulty. In a large MS clinic population (N = 838), 9.4% of the patients had late onset of MS. Slow deterioration of motor function characterized the initial symptoms and subsequent course of this group of older...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.12.1537

    authors: Noseworthy J,Paty D,Wonnacott T,Feasby T,Ebers G

    更新日期:1983-12-01 00:00:00

  • Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA.

    abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31829c5ed5

    authors: Josephs KA,Duffy JR,Strand EA,Machulda MM,Senjem ML,Lowe VJ,Jack CR Jr,Whitwell JL

    更新日期:2013-07-23 00:00:00

  • Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial.

    abstract:BACKGROUND:Physicians are often asked to predict outcome after acute stroke. Very little information is available that can reliably predict the likelihood of severe disability or death. OBJECTIVE:To develop a practical method for predicting a poor outcome after acute ischemic stroke. METHODS:Data from the placebo arm...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.7.952

    authors: Frankel MR,Morgenstern LB,Kwiatkowski T,Lu M,Tilley BC,Broderick JP,Libman R,Levine SR,Brott T

    更新日期:2000-10-10 00:00:00

  • Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.

    abstract:BACKGROUND:Both AD and normal aging cause brain atrophy, limiting the ability of MRI to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging. OBJECTIVES:To determine the effects of AD on c...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/wnl.58.6.928

    authors: Schuff N,Capizzano AA,Du AT,Amend DL,O'Neill J,Norman D,Kramer J,Jagust W,Miller B,Wolkowitz OM,Yaffe K,Weiner MW

    更新日期:2002-03-26 00:00:00

  • Multiple cerebral hemorrhages in HTLV-I-associated myelopathy.

    abstract::We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.2.412

    authors: Smith D,Lucas S,Jacewicz M

    更新日期:1993-02-01 00:00:00

  • Reduction in voice tremor under thalamic stimulation.

    abstract::We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.50.3.796

    authors: Carpenter MA,Pahwa R,Miyawaki KL,Wilkinson SB,Searl JP,Koller WC

    更新日期:1998-03-01 00:00:00

  • Naming vs knowing faces in primary progressive aphasia: a tale of 2 hemispheres.

    abstract:OBJECTIVES:This study examines the anatomical correlates of naming vs recognizing faces using a novel measure that utilizes culturally relevant and age-appropriate items, the Northwestern University Famous Faces (NUFFACE) Test, in primary progressive aphasia (PPA), a syndrome characterized by progressive language defic...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182a08f83

    authors: Gefen T,Wieneke C,Martersteck A,Whitney K,Weintraub S,Mesulam MM,Rogalski E

    更新日期:2013-08-13 00:00:00

  • Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke. North American Symptomatic Carotid Endarterectomy Trial Group.

    abstract:OBJECTIVE:To examine the relationship between carotid artery stenosis, other risk factors, and lacunar stroke. BACKGROUND:Carotid artery stenosis in patients presenting with lacune stroke may be coincidental or causal. The distinction by risk factor profile is uncertain. The risk and cause of subsequent stroke, and be...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.3.660

    authors: Inzitari D,Eliasziw M,Sharpe BL,Fox AJ,Barnett HJ

    更新日期:2000-02-08 00:00:00

  • Network dysfunction predicts speech production after left hemisphere stroke.

    abstract:OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002537

    authors: Geranmayeh F,Leech R,Wise RJS

    更新日期:2016-04-05 00:00:00

  • Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.

    abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008696

    authors: Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

    更新日期:2020-01-07 00:00:00

  • Psychosocial aspects of Parkinson's disease.

    abstract::Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:

    authors: Ellgring H,Seiler S,Perleth B,Frings W,Gasser T,Oertel W

    更新日期:1993-12-01 00:00:00

  • Musical murmurs on transcranial ultrasound in childhood migraine with aura.

    abstract::A 12-year-old girl presented with headache, nausea, decreased level of consciousness, and diplopia. Brain MRI, arteriography (figure e-1 on the Neurology® Web site at www.neurology.org), vasculitic markers, and CSF were normal, as were EEGs and ECGs. Transcranial color-coded ultrasonography of the basilar artery revea...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000436064.90018.48

    authors: Kraft P,Müllges W

    更新日期:2013-11-19 00:00:00