Transient drug-induced abolition of BAEPs in coma.


:Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but were never isoelectric. BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine.






García-Larrea L,Artru F,Bertrand O,Pernier J,Mauguière F




Has Abstract


1988-09-01 00:00:00












  • Evaluation of dysphagia by novel real-time MRI.

    abstract:OBJECTIVE:To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). METHODS:Using RT-MRI, FEES, and ...


    pub_type: 杂志文章


    authors: Olthoff A,Carstens PO,Zhang S,von Fintel E,Friede T,Lotz J,Frahm J,Schmidt J

    更新日期:2016-11-15 00:00:00

  • Cholinergic enhancement and REM sleep latency in the aged: lecithin does not reproduce physostigmine effect.

    abstract::The administration of lecithin has failed to improve memory in aged or demented individuals. We studied the effect of lecithin on another cholinergic function, REM sleep latency. Intravenous doses of physostigmine shortened the latency to the first REM sleep period, but oral lecithin did not. In contrast to physostigm...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kapen S,Fleming PD,Drachman DA

    更新日期:1986-08-01 00:00:00

  • Angioplasty and stenting for stroke prevention: good questions that need answers.

    abstract::Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...


    pub_type: 杂志文章,评审


    authors: Chaturvedi S,Fessler R

    更新日期:2002-09-10 00:00:00

  • Multifocal visual evoked potentials are influenced by variable contrast stimulation in MS.

    abstract:OBJECTIVE:To test the hypothesis that patients with multiple sclerosis (MS) with intereye asymmetry on low contrast letter acuity, and thickness of the retinal nerve fiber layer (RNFL), would exhibit corresponding changes in cortical timing and amplitude responses on pattern reversal multifocal visual evoked potentials...


    pub_type: 杂志文章


    authors: Frohman AR,Schnurman Z,Conger A,Conger D,Beh S,Greenberg B,Sutter E,Calabresi PA,Balcer LJ,Frohman TC,Frohman EM

    更新日期:2012-08-21 00:00:00

  • Behavioral assessment of peripheral nerve function.

    abstract::Behavioral psychophysical techniques were used to obtain strength-duration curves for the ulnar nerve at both threshold and suprathreshold levels. The functions well match those obtained with electrophysiologic procedures, but overcome many of the difficulities associated with traditional electrodiagnosis. An alternat...


    pub_type: 杂志文章


    authors: Rollman GB

    更新日期:1975-04-01 00:00:00

  • Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.

    abstract:OBJECTIVE:To identify the disease-causing gene of a family with upper limb predominant, slowly progressive amyotrophic lateral sclerosis (ALS), which was diagnosed as flail arm syndrome (FAS). METHODS:After causation of 24 known ALS genes was excluded by targeted next-generation sequencing, whole-exome sequencing was ...


    pub_type: 杂志文章


    authors: Liu Q,Shu S,Wang RR,Liu F,Cui B,Guo XN,Lu CX,Li XG,Liu MS,Peng B,Cui LY,Zhang X

    更新日期:2016-10-25 00:00:00

  • Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

    abstract:OBJECTIVE:To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality. METHODS:In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Me...


    pub_type: 杂志文章


    authors: Benito-León J,Romero JP,Louis ED,Bermejo-Pareja F

    更新日期:2014-04-22 00:00:00

  • Parry-Romberg syndrome: a global survey of 205 patients using the Internet.

    abstract::Parry-Romberg syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive facial hemiatrophy. In this study, 205 patients with PRS were surveyed using the Internet. Estimates of the frequency of limb involvement (19%), epilepsy (11%), and other clinical and etiologic features were obtained. There was...


    pub_type: 杂志文章


    authors: Stone J

    更新日期:2003-09-09 00:00:00

  • Infarcts with a cardiac source of embolism in the NINCDS Stroke Data Bank: historical features.

    abstract::To gain insight into the historical features relevant to the diagnosis of cardiac embolic strokes, we studied the 1,290 patients with cerebral infarcts in the NINCDS Stroke Data Bank. Based solely on the presence of cardiac sources of embolism, we divided the patients into groups of high (n = 250), medium (n = 166), a...


    pub_type: 杂志文章


    authors: Kittner SJ,Sharkness CM,Price TR,Plotnick GD,Dambrosia JM,Wolf PA,Mohr JP,Hier DB,Kase CS,Tuhrim S

    更新日期:1990-02-01 00:00:00

  • Relationship between etiology and covert cognition in the minimally conscious state.

    abstract:OBJECTIVES:Functional neuroimaging has shown that the absence of externally observable signs of consciousness and cognition in severely brain-injured patients does not necessarily indicate the true absence of such abilities. However, relative to traumatic brain injury, nontraumatic injury is known to be associated with...


    pub_type: 杂志文章


    authors: Cruse D,Chennu S,Chatelle C,Fernández-Espejo D,Bekinschtein TA,Pickard JD,Laureys S,Owen AM

    更新日期:2012-03-13 00:00:00

  • The localizing value of ictal EEG in focal epilepsy.

    abstract:OBJECTIVE:To investigate the lateralization and localization of ictal EEG in focal epilepsy. METHODS:A total of 486 ictal EEG of 72 patients with focal epilepsy arising from the mesial temporal, neocortical temporal, mesial frontal, dorsolateral frontal, parietal, and occipital regions were analyzed. RESULTS:Surface ...


    pub_type: 杂志文章


    authors: Foldvary N,Klem G,Hammel J,Bingaman W,Najm I,Lüders H

    更新日期:2001-12-11 00:00:00

  • Evidence against the existence of a temporal lobe epilepsy personality syndrome.

    abstract::The existence and specificity of a characteristic behavioral syndrome among patients with temporal lobe epilepsy (TLE) remains controversial. The behavioral pattern of many epilepsy patients differs from that of age-, sex-, and socioeconomic-matched control subjects. Patients with TLE and other forms of epilepsy can e...


    pub_type: 杂志文章,评审


    authors: Devinsky O,Najjar S

    更新日期:1999-01-01 00:00:00

  • APOE epsilon4 and the cognitive genetics of multiple sclerosis.

    abstract:BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...


    pub_type: 杂志文章


    authors: Ghaffar O,Reis M,Pennell N,O'Connor P,Feinstein A

    更新日期:2010-05-18 00:00:00

  • On the cause of hyporeflexia in the Holmes-Adie syndrome.

    abstract::Electrophysiologic studies were carried out on 11 patients with Holmes-Adie syndrome, 8 of whom had reduced or absent ankle jerks. Conduction velocities and evoked nerve and muscle compound action potentials in the peroneal, posterior tibial, and sural nerves were normal. The H reflex was absent (or virtually absent) ...


    pub_type: 杂志文章


    authors: Miyasaki JM,Ashby P,Sharpe JA,Fletcher WA

    更新日期:1988-02-01 00:00:00

  • A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis.

    abstract:OBJECTIVE:To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis. METHODS:Three hundred eighty-two patients with detailed information and functional status at 1 year were studied. Factors associated with poor status (defined as modified Rankin S...


    pub_type: 杂志文章


    authors: Balu R,McCracken L,Lancaster E,Graus F,Dalmau J,Titulaer MJ

    更新日期:2019-01-15 00:00:00

  • Idiopathic intracranial hypertension without papilledema: a case-control study in a headache center.

    abstract:OBJECTIVE:To compare the clinical features of patients with chronic daily headache (CDH) with idiopathic intracranial hypertension without papilledema (IIHWOP) to those with normal CSF pressure. METHODS:A case-control study was conducted at a tertiary headache center. Cases consisted of 25 consecutive patients (24 wom...


    pub_type: 杂志文章


    authors: Wang SJ,Silberstein SD,Patterson S,Young WB

    更新日期:1998-07-01 00:00:00

  • Individual differences in endogenous pain modulation as a risk factor for chronic pain.

    abstract::This review summarizes evidence, primarily from recent human studies, indirectly supporting a novel hypothesis: that the assessment of healthy individuals' responses to standardized noxious stimuli in a controlled laboratory environment has important implications for the later risk of developing a broad spectrum of ch...


    pub_type: 杂志文章,评审


    authors: Edwards RR

    更新日期:2005-08-09 00:00:00

  • Effects of valproic acid in cultured mammalian neurons.

    abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...


    pub_type: 杂志文章


    authors: Buchhalter JR,Dichter MA

    更新日期:1986-02-01 00:00:00

  • Effect of comorbidity on mortality in multiple sclerosis.

    abstract:OBJECTIVE:We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS:Using population-based administrative data, we identified 5,797 persons with MS and 28,807 contro...


    pub_type: 杂志文章


    authors: Marrie RA,Elliott L,Marriott J,Cossoy M,Blanchard J,Leung S,Yu N

    更新日期:2015-07-21 00:00:00

  • Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study.

    abstract:OBJECTIVES:To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS:This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-bl...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Garcia-Borreguero D,Larrosa O,Williams AM,Albares J,Pascual M,Palacios JC,Fernandez C

    更新日期:2010-06-08 00:00:00

  • Impairment of hand movements under visual guidance.

    abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...


    pub_type: 杂志文章


    authors: Damasio AR,Benton AL

    更新日期:1979-02-01 00:00:00

  • Seeing ophthalmologic problems in Parkinson disease: Results of a visual impairment questionnaire.

    abstract:OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...


    pub_type: 杂志文章,多中心研究


    authors: Borm CDJM,Visser F,Werkmann M,de Graaf D,Putz D,Seppi K,Poewe W,Vlaar AMM,Hoyng C,Bloem BR,Theelen T,de Vries NM

    更新日期:2020-04-07 00:00:00

  • A phase 3 randomized study evaluating sialic acid extended-release for GNE myopathy.

    abstract:OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lochmüller H,Behin A,Caraco Y,Lau H,Mirabella M,Tournev I,Tarnopolsky M,Pogoryelova O,Woods C,Lai A,Shah J,Koutsoukos T,Skrinar A,Mansbach H,Kakkis E,Mozaffar T

    更新日期:2019-04-30 00:00:00

  • Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans.

    abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...


    pub_type: 杂志文章


    authors: Kornblith E,Peltz CB,Xia F,Plassman B,Novakovic-Apopain T,Yaffe K

    更新日期:2020-09-29 00:00:00

  • Multifocal motor neuropathy: serum IgM binding to a GM1 ganglioside-containing lipid mixture but not to GM1 alone.

    abstract::IgM anti-GM1 antibodies are associated with motor neuropathy syndromes, including multifocal motor neuropathy (MMN). We compared the ability of serum IgM from patients with multifocal motor neuropathy to bind to GM1 ganglioside alone and to GM1 as a component of a lipid mixture that also contained galactocerebroside a...


    pub_type: 杂志文章


    authors: Pestronk A,Choksi R,Blume G,Lopate G

    更新日期:1997-04-01 00:00:00

  • The sensitivity and specificity of MRI in stroke.

    abstract::We compared MRI and CT in a study of 175 patients; 87 infarcts within a week, 40 from 1 to 40 weeks, 25 a year after onset, and 23 hemorrhages, 18 within 2 weeks and 5 in 4 to 8 weeks. Fifty-nine infarcts and eight hemorrhages had sequential scanning. MRI is more sensitive than CT in the early detection of cerebral in...


    pub_type: 杂志文章


    authors: Kertesz A,Black SE,Nicholson L,Carr T

    更新日期:1987-10-01 00:00:00

  • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III).

    abstract:OBJECTIVE:To replicate the beneficial effect of brain-derived neurotrophic factor (BDNF) in 1,135 ALS patients in a multicenter trial. BACKGROUND:In a phase I through II study, BDNF appeared to increase survival and retard loss of pulmonary function in ALS patients. METHODS:Patients were randomized to placebo, or 25 ...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1999-04-22 00:00:00

  • A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy.

    abstract:BACKGROUND:Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. METHODS:Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory...


    pub_type: 杂志文章,随机对照试验


    authors: Fallon BA,Keilp JG,Corbera KM,Petkova E,Britton CB,Dwyer E,Slavov I,Cheng J,Dobkin J,Nelson DR,Sackeim HA

    更新日期:2008-03-25 00:00:00

  • Osteopenia and osteoporosis in idiopathic benign positional vertigo.

    abstract:OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...


    pub_type: 杂志文章


    authors: Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

    更新日期:2009-03-24 00:00:00

  • Sensitivity and specificity of transcranial Doppler ultrasonography in the diagnosis of vasospasm following subarachnoid hemorrhage.

    abstract::Vasospasm is the leading cause of death and disability in patients with aneurysmal subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography (TCD) can detect the arterial narrowing noninvasively, but the sensitivity and specificity of this technique have not been reported in a population of patients with a h...


    pub_type: 杂志文章


    authors: Sloan MA,Haley EC Jr,Kassell NF,Henry ML,Stewart SR,Beskin RR,Sevilla EA,Torner JC

    更新日期:1989-11-01 00:00:00