Abstract:
:In spinal cords from seven amyotrophic lateral sclerosis (ALS) patients and four controls, we found no difference in thyrotropin-releasing hormone (TRH) concentration relative to protein content, but there was a reduction per tissue wet weight in ALS. Immunohistochemical localization of TRH in ALS cord was unaltered. Histidyl proline diketopiperazine (HisPro-DKP), a possible metabolite of TRH, was significantly elevated per protein content in ALS. CSF levels of TRH and HisPro-DKP were unchanged. These findings suggest that TRH neurons are not primarily affected in ALS, but TRH and tissue protein are lost together as the disease progresses.
journal_name
Neurologyjournal_title
Neurologyauthors
Jackson IM,Adelman LS,Munsat TL,Forte S,Lechan RMdoi
10.1212/wnl.36.9.1218subject
Has Abstractpub_date
1986-09-01 00:00:00pages
1218-23issue
9eissn
0028-3878issn
1526-632Xjournal_volume
36pub_type
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