Abstract:
:Inhibitory antibody to von Willebrand factor (vWF)-cleaving protease (ADAMTS13) was detected in a patient with intravascular lymphomatosis. The increased serum level of the antibody paralleled an increase in the expression of uncleaved vWF, which might cause microvascular thrombosis and platelet consumption. Malignant cell proliferations with superimposed thrombosis within the lumina throughout the entire vasculature account for diffuse neurodeficits observed in the patient.
journal_name
Neurologyjournal_title
Neurologyauthors
Kawahara M,Kanno M,Matsumoto M,Nakamura S,Fujimura Y,Ueno Sdoi
10.1212/01.wnl.0000143065.55002.67subject
Has Abstractpub_date
2004-11-09 00:00:00pages
1731-3issue
9eissn
0028-3878issn
1526-632Xpii
63/9/1731journal_volume
63pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.62.5_suppl_2.s17
更新日期:2004-03-09 00:00:00
abstract::We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.7.710
更新日期:1978-07-01 00:00:00
abstract::We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.440
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000185
更新日期:2014-03-11 00:00:00
abstract:OBJECTIVE:To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003. METHODS:All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, H...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000195549.95448.b9
更新日期:2006-01-24 00:00:00
abstract:OBJECTIVE:To investigate specificity and significance of dynamic changes of the cervical dural sac and spinal cord during neck flexion in juvenile muscular atrophy of the distal upper extremity. BACKGROUND:The disorder affects young people-predominantly men-and is progressive for several years. One autopsy case showed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.10.1922
更新日期:2000-05-23 00:00:00
abstract::Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.5.422
更新日期:1975-05-01 00:00:00
abstract::[Methyl-3H]epsilon-N-trimethyl-L-lysine was administered to patients with primary systemic carnitine deficiency and to controls. In both groups, labeled carnitine appeared in blood and urine within 2 hours, and the specific radioactivity of urinary carnitine peaked between 2 and 6 hours. The specific radioactivity of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.7.813
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVE:To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. METHODS:The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000216259.99811.50
更新日期:2006-05-23 00:00:00
abstract:OBJECTIVE:To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors. METHODS:Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one E...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000237475.01655.9d
更新日期:2006-09-26 00:00:00
abstract:OBJECTIVE:To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.2.319
更新日期:2000-01-25 00:00:00
abstract:OBJECTIVE:To evaluate the effect of simulation-based mastery learning (SBML) on internal medicine residents' lumbar puncture (LP) skills, assess neurology residents' acquired LP skills from traditional clinical education, and compare the results of SBML to traditional clinical education. METHODS:This study was a prete...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31825dd39d
更新日期:2012-07-10 00:00:00
abstract:OBJECTIVE:To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls. METHODS:The authors assessed demographic and clinical information including use of hearing aids in 250 patients with ET, 127 patients with PD, and 127 normal controls. The authors administere...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000086376.40750.af
更新日期:2003-10-28 00:00:00
abstract::We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.44.3_part_1.429
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Although gray matter (GM) atrophy is recognized as a common feature of multiple sclerosis (MS), conflicting results have been obtained in patients with clinically isolated syndromes (CIS). Methodologic and clinical constraints may take account for literature discrepancies. METHODS:A total of 105 patients pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318220abd4
更新日期:2011-07-19 00:00:00
abstract::The authors describe a patient with sporadic distal myopathy associated with reduced caveolin-3 in muscle fibers in which the muscle atrophy was restricted to the small muscles of the hands and feet. Gene analysis disclosed a heterozygous 80 G-->A substitution in the caveolin-3 gene that was identical to that of repor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.323
更新日期:2002-01-22 00:00:00
abstract::A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000134672.44217.f7
更新日期:2004-08-24 00:00:00
abstract:OBJECTIVE:Guillain-Barré syndrome (GBS) is characterized by nerve infiltration of leukocytes and autoantibodies of the immunoglobulin G (IgG) isotype directed against nerve constituents. Leukocyte receptors for IgG (FcgammaR) constitute an important link between the humoral and cellular parts of the immune system and c...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.54.8.1661
更新日期:2000-04-25 00:00:00
abstract::The local cerebral metabolic rate for glucose (1=CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.4.377
更新日期:1982-04-01 00:00:00
abstract::Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3.682
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS:We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006467
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Alexander disease is most commonly associated with macrocephaly and, on MRI, a leukoencephalopathy with frontal preponderance. The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized. METHODS:The authors studied seven patients with Alexande...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000198770.80743.37
更新日期:2006-02-28 00:00:00
abstract::The antimigraine efficacy of many drugs may be mediated less through their primary modes of action than through the common pathway of serotonergic transmission stabilization. Migraine treatment may be symptomatic, acute/abortive, or prophylactic. Because oral drug absorption is impaired during attacks, parenteral agen...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-01 00:00:00
abstract::We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.43.12.2466
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS:Data were from a population-based cohort st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000319647.15752.7b
更新日期:2008-07-29 00:00:00
abstract:OBJECTIVE:To determine the current best practice for treatment of infantile spasms in children. METHODS:Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000127773.72699.c8
更新日期:2004-05-25 00:00:00
abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.726
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To study the difference in risk for dementing diseases between men and women. BACKGROUND:Previous studies suggest women have a higher risk for dementia than men. However, these studies include small sample sizes, particularly in the older age groups, when the incidence of dementia is highest. METHODS:Pooled...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.1992
更新日期:1999-12-10 00:00:00
abstract::This update to the American Academy of Neurology's 1998 position statement endeavors to provide guidance for the consistent ethical conduct and review of neurologic research involving human participants. It does so by outlining a widely used ethical framework of 7 principles derived from the foundational documents of ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000009241
更新日期:2020-04-14 00:00:00
abstract::A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.1.68
更新日期:1987-01-01 00:00:00