Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.

abstract：OBJECTIVE:To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS:Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS:Speech w...

journal_title：Neurology

authors： Turner SJ,Brown A,Arpone M,Anderson V,Morgan AT,Scheffer IE

更新日期：2017-02-21 00:00:00

abstract：:T lymphocytes may play a central role in MS. The search for more targeted immunosuppression than is currently available has led to recent clinical trials of novel therapeutics. We studied 29 patients in a double-blind placebo-controlled trial of the chimeric monoclonal anti-CD4 antibody, cM-T412 (Centocor, Leiden, Hol...

journal_title：Neurology

authors： Llewellyn-Smith N,Lai M,Miller DH,Rudge P,Thompson AJ,Cuzner ML

更新日期：1997-04-01 00:00:00

abstract：:Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer's cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures o...

journal_title：Neurology

authors： Tinazzi M,Farina S,Bhatia K,Fiaschi A,Moretto G,Bertolasi L,Zarattini S,Smania N

更新日期：2005-06-14 00:00:00

abstract：OBJECTIVE:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. METHODS:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 w...

journal_title：Neurology

authors： Labbé C,Ogaki K,Lorenzo-Betancor O,Soto-Ortolaza AI,Walton RL,Rayaprolu S,Fujioka S,Murray ME,Heckman MG,Puschmann A,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska M,Czyzewski K,Sanotsky Y

更新日期：2015-11-10 00:00:00

abstract：OBJECTIVE:The presence of cranial autonomic symptoms often leads to a misdiagnosis of "sinus headache" in adult migraineurs, leading to unnecessary treatments and delaying appropriate migraine therapy. In this study, we examined the frequency of cranial autonomic symptoms in pediatric/adolescent patients with migraine....

journal_title：Neurology

authors： Gelfand AA,Reider AC,Goadsby PJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...

journal_title：Neurology

authors： Ghaffar O,Reis M,Pennell N,O'Connor P,Feinstein A

更新日期：2010-05-18 00:00:00

abstract：OBJECTIVE:To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS:We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18...

journal_title：Neurology

authors： Ishii K,Imamura T,Sasaki M,Yamaji S,Sakamoto S,Kitagaki H,Hashimoto M,Hirono N,Shimomura T,Mori E

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents. However, the resultan...

journal_title：Neurology

authors： Jaeckle KA,Ballman K,Furth A,Buckner JC

更新日期：2009-10-13 00:00:00

abstract：:Article abstract Depressive disorders (DDs) are the most common type of psychiatric co-morbidity in patients with epilepsy. They are more likely to occur in patients with partial seizure disorders of temporal and frontal lobe origin and are more frequent among patients with poorly controlled seizures. Despite their re...

journal_title：Neurology

authors： Kanner AM,Balabanov A

更新日期：2002-04-23 00:00:00

abstract：OBJECTIVE:Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy. METHODS:RNFL thickness was measured in 40 patients with MS and 15 controls. Brain parenchymal frac...

journal_title：Neurology

authors： Gordon-Lipkin E,Chodkowski B,Reich DS,Smith SA,Pulicken M,Balcer LJ,Frohman EM,Cutter G,Calabresi PA

更新日期：2007-10-16 00:00:00

abstract：OBJECTIVE:To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men. BACKGROUND:X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women. MET...

journal_title：Neurology

authors： Guerrini R,Mei D,Sisodiya S,Sicca F,Harding B,Takahashi Y,Dorn T,Yoshida A,Campistol J,Krämer G,Moro F,Dobyns WB,Parrini E

更新日期：2004-07-13 00:00:00

abstract：OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...

journal_title：Neurology

authors： Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

更新日期：2020-05-12 00:00:00

abstract：:The clinical and radiologic impact of developing neutralizing antibodies (NAbs) to interferon beta (IFNbeta) while on this therapy for multiple sclerosis (MS) is assessed. On the basis of Class II and III evidence, it is concluded that treatment of patients with MS with IFNbeta (Avonex, Betaseron, or Rebif) is associa...

journal_title：Neurology

authors： Goodin DS,Frohman EM,Hurwitz B,O'Connor PW,Oger JJ,Reder AT,Stevens JC

更新日期：2007-03-27 00:00:00

abstract：:Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with...

journal_title：Neurology

authors： Jagust WJ,Davies P,Tiller-Borcich JK,Reed BR

更新日期：1990-01-01 00:00:00

abstract：:Urinary incontinence (UI) after stroke is common and associated with overall poor functional outcomes. There is controversy regarding which factors contribute to incontinence after stroke and which factors may be predictive of recovery of continence. This study investigated consecutive stroke admissions to an inpatien...

journal_title：Neurology

authors： Ween JE,Alexander MP,D'Esposito M,Roberts M

更新日期：1996-09-01 00:00:00

abstract：:This double-blind, placebo-controlled, crossover study of the acute treatment of migraine investigated the efficacy and tolerability of oral sumatriptan 100 mg (Imitrex) administered for up to nine attacks compared with placebo administered for up to three attacks. Patients were randomized to receive oral sumatriptan ...

journal_title：Neurology

authors： Rederich G,Rapoport A,Cutler N,Hazelrigg R,Jamerson B

更新日期：1995-08-01 00:00:00

abstract：:Data from three patients and 22 previously reported cases suggest that cerebral microinfarction causes a recognizable clinical syndrome. All cases present with stroke, followed by progressive dementia and often with visual field deficits, peripheral vascular disease, and signs of motor neuron dysfunction. The average ...

journal_title：Neurology

authors： Kaplan JG,Katzman R,Horoupian DS,Fuld PA,Mayeux R,Hays AP

更新日期：1985-06-01 00:00:00

abstract：:The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...

journal_title：Neurology

authors： Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

更新日期：2003-07-08 00:00:00

abstract：OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...

journal_title：Neurology

authors： Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES/METHODS:To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990. RESULTS:One intention-to-treat Class I randomized, controlled trial of surgery for mesial te...

journal_title：Neurology

authors： Engel J Jr,Wiebe S,French J,Sperling M,Williamson P,Spencer D,Gumnit R,Zahn C,Westbrook E,Enos B,Quality Standards Subcommittee of the American Academy of Neurology.,American Epilepsy Society.,American Association of Neurological

更新日期：2003-02-25 00:00:00

abstract：OBJECTIVE:To assess functional changes in lymphocyte repertoire and subsequent clinical implications during delayed-release dimethyl fumarate (DMF) treatment in patients with multiple sclerosis. METHODS:Using peripheral blood from several clinical trials of DMF, immune cell subsets were quantified using flow cytometry...

journal_title：Neurology

authors： Mehta D,Miller C,Arnold DL,Bame E,Bar-Or A,Gold R,Hanna J,Kappos L,Liu S,Matta A,Phillips JT,Robertson D,von Hehn CA,Campbell J,Spach K,Yang L,Fox RJ

更新日期：2019-04-09 00:00:00

abstract：:In 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 11 patients with chronic idiopathic axonal polyneuropathy (CIAP), absent myotatic reflexes were significantly associated more often with CIDP than with CIAP, an absent biceps-reflex having the highest sensitivity and specificity for the d...

journal_title：Neurology

authors： van Dijk GW,Wokke JH,Notermans NC,van Gijn J,Franssen H

更新日期：1999-10-22 00:00:00

abstract：:A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...

journal_title：Neurology

authors： Capellari S,Parchi P,Wolff BD,Campbell J,Atkinson R,Posey DM,Petersen RB,Gambetti P

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD. METHODS:Eleven patients with mild AD received rivastigmine for 12 months. Cholinesterase (ChE) activities in the CSF and plasma were assessed colorimetrically. ...

journal_title：Neurology

authors： Darreh-Shori T,Almkvist O,Guan ZZ,Garlind A,Strandberg B,Svensson AL,Soreq H,Hellström-Lindahl E,Nordberg A

更新日期：2002-08-27 00:00:00

abstract：:Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...

journal_title：Neurology

authors： Rutgers MJ,van der Lugt PJ,van Turnhout JM

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...

journal_title：Neurology

authors： Helzner EP,Scarmeas N,Cosentino S,Tang MX,Schupf N,Stern Y

更新日期：2008-11-04 00:00:00

abstract：OBJECTIVE:To determine the incidence of first seizures, epilepsy, and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition, which allows an epilepsy diagnosis after a single seizure when the risk of further seizures over the next 10 years is ≈60%...

journal_title：Neurology

authors： Maloney EM,Chaila E,O'Reilly ÉJ,Costello DJ

更新日期：2020-08-04 00:00:00

abstract：:The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...

journal_title：Neurology

authors： Knupp K,Wirrell E

更新日期：2014-02-04 00:00:00

abstract：:We obtained continuous EEG/video recordings on four children who had the interictal EEG pattern of multifocal independent epileptiform discharges (MIED). The prominent feature of their evaluation was the evidence that their clinical seizures appeared to be of focal origin; 42/44 seizures were manifested by "fencing po...

journal_title：Neurology

authors： Burnstine TH,Vining EP,Uematsu S,Lesser RP

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...

journal_title：Neurology

authors： Stemper B,Bernardi L,Axelrod FB,Welsch G,Passino C,Hilz MJ

更新日期：2004-10-26 00:00:00