Abstract:
:Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with neuritic plaques and neurofibrillary tangles, in addition to degeneration of the nucleus basalis and locus ceruleus. Neurochemical and immunocytochemical studies showed a moderate cortical cholinergic deficiency with normal somatostatin-like immunoreactivity and a profuse immunostaining of somatosensory cortex with the Alz-50 antibody. These unusual features emphasize that Alzheimer's disease is extremely variable in its clinical symptomatology, pathologic distribution, and neurochemical dimensions.
journal_name
Neurologyjournal_title
Neurologyauthors
Jagust WJ,Davies P,Tiller-Borcich JK,Reed BRdoi
10.1212/wnl.40.1.14subject
Has Abstractpub_date
1990-01-01 00:00:00pages
14-9issue
1eissn
0028-3878issn
1526-632Xjournal_volume
40pub_type
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