Abstract:
:Mammalian spinal neurons grown in tissue culture were used to study the effects of the four convulsants-penicillin, pentylenetetrazol, picrotoxin, and bicuculline-on these neurons' responses to amino acids. Bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis of the four convulsants selectively depressed responses produced by iontophoresis of the putative inhibitory transmitter GABA, and effected this depression without altering either inhibitory responses to beta-alanine or glycine, or excitation mediated by glutamate. These results support the hypothesis that the convulsant activity of these agents comes in part from selective antagonism of GABA-mediated postsynaptic inhibition.
journal_name
Neurologyjournal_title
Neurologyauthors
Macdonald RL,Barker JLdoi
10.1212/wnl.28.4.325subject
Has Abstractpub_date
1978-04-01 00:00:00pages
325-30issue
4eissn
0028-3878issn
1526-632Xjournal_volume
28pub_type
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