Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Topiramate YD Study Group.

Abstract:

:We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients with refractory partial onset epilepsy receiving one or two other AEDs at therapeutic concentrations. A total of 181 patients completed the 12-week baseline phase and were randomized to double-blind therapy. Median percent reductions from baseline in average monthly seizure rate, the principal efficacy evaluation, were 13% for placebo, 30% for topiramate 200 mg/day, 48% for topiramate 400 mg/day, and 45% for topiramate 600 mg/day. For the seizure rate comparison of active drug to placebo p values were: topiramate 200 mg/day, p = 0.051; topiramate 400 mg/day, p = 0.007; topiramate 600 mg/day, p < 0.001. Percent responders ( > or = 50% reduction in seizure rates) were 18% for placebo, 27% for topiramate 200 mg/day, 47% for topiramate 400 mg/day (p = 0.013), and 46% for topiramate 600 mg/day (p = 0.027). A significant (p = 0.003) reduction in secondarily generalized seizures compared with placebo treatment was also documented with topiramate. Topiramate plasma concentrations were closely related to dosage, and there were no significant interactions between topiramate and other AEDs. The minimal effective dose of topiramate in this study population was approximately 200 mg/day. Mild or moderate CNS symptoms were the primary treatment-emergent adverse events, but treatment-limiting adverse events occurred in only 9% of patients given topiramate compared with 7% given placebo. Results of this initial well-controlled study in patients indicate that topiramate is a very promising new AED.

journal_name

Neurology

journal_title

Neurology

authors

Faught E,Wilder BJ,Ramsay RE,Reife RA,Kramer LD,Pledger GW,Karim RM

doi

10.1212/wnl.46.6.1684

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

1684-90

issue

6

eissn

0028-3878

issn

1526-632X

journal_volume

46

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Speech without conscious awareness.

    abstract::Following commissurotomy, it is usually the case that information presented to the left hemisphere can be named and described, while information presented to the mute, right hemisphere cannot be spoken about. In the present study, it was discovered that under special test conditions, an MRI-verified, callosally sectio...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.4.682

    authors: Gazzaniga MS,Holtzman JD,Smylie CS

    更新日期:1987-04-01 00:00:00

  • A case-control and nerve biopsy study of CREST multiple mononeuropathy.

    abstract::From 536 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis), seven were identified as having peripheral neuropathy not attributable to another cause. Peripheral neuropathy developed 0 to 25 years after their first symptoms of scleroderma. Unex...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.6.1641

    authors: Dyck PJ,Hunder GG,Dyck PJ

    更新日期:1997-12-01 00:00:00

  • Metabolic correlates of levodopa response in Parkinson's disease.

    abstract:OBJECTIVE:To assess the effects of levodopa on resting-state brain metabolism in PD. BACKGROUND:In previous studies the authors used [18F] fluorodeoxyglucose (FDG) and PET to quantify regional metabolic abnormalities in PD. They found that this disease is characterized reproducibly by a specific abnormal PD-related pa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.11.2083

    authors: Feigin A,Fukuda M,Dhawan V,Przedborski S,Jackson-Lewis V,Mentis MJ,Moeller JR,Eidelberg D

    更新日期:2001-12-11 00:00:00

  • Adult-onset leukoencephalopathy with vanishing white matter with a missense mutation in EIF2B5.

    abstract::We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white mat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000123117.11264.0e

    authors: Ohtake H,Shimohata T,Terajima K,Kimura T,Jo R,Kaseda R,Iizuka O,Takano M,Akaiwa Y,Goto H,Kobayashi H,Sugai T,Muratake T,Hosoki T,Shioiri T,Okamoto K,Onodera O,Tanaka K,Someya T,Nakada T,Tsuji S

    更新日期:2004-05-11 00:00:00

  • Socioeconomic status and disability progression in multiple sclerosis: A multinational study.

    abstract:OBJECTIVE:To examine the association between socioeconomic status (SES) and disability outcomes and progression in multiple sclerosis (MS). METHODS:Health administrative and MS clinical data were linked for 2 cohorts of patients with MS in British Columbia (Canada) and South East Wales (UK). SES was measured at MS sym...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007190

    authors: Harding KE,Wardle M,Carruthers R,Robertson N,Zhu F,Kingwell E,Tremlett H

    更新日期:2019-03-26 00:00:00

  • Measuring disease progression in frontotemporal lobar degeneration: a clinical and MRI study.

    abstract:OBJECTIVES:There is currently much interest in biomarkers of disease activity in frontotemporal lobar degeneration (FTLD). We assessed MRI and behavioral measures of progression in a longitudinal FTLD cohort. METHODS:Thirty-two patients with FTLD (11 behavioral variant frontotemporal dementia [bvFTD], 11 semantic deme...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181d1a879

    authors: Gordon E,Rohrer JD,Kim LG,Omar R,Rossor MN,Fox NC,Warren JD

    更新日期:2010-02-23 00:00:00

  • Migraine in pregnancy.

    abstract::Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

    authors: Aubé M

    更新日期:1999-01-01 00:00:00

  • Altered pharmacokinetics of L-dopa metabolism in rat striatum deprived of dopaminergic innervation.

    abstract::Rats with unilateral lesions of the substantia nigra were treated with L-dopa 25 mg/kg subcutaneously 30 minutes after treatment with carbidopa 25 mg/kg intraperitoneally. In the ipsilateral striatum, dopamine levels achieved a peak of 1.57 +/- 0.63 micrograms/g (control 0.19 +/- 0.05 micrograms/g) at 20 minutes and d...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.8.1105

    authors: Spencer SE,Wooten GF

    更新日期:1984-08-01 00:00:00

  • Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003512

    authors: Thomas AJ,Attems J,Colloby SJ,O'Brien JT,McKeith I,Walker R,Lee L,Burn D,Lett DJ,Walker Z

    更新日期:2017-01-17 00:00:00

  • Multifocal central nervous system damage caused by toluene abuse.

    abstract::Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.10.1337

    authors: Lazar RB,Ho SU,Melen O,Daghestani AN

    更新日期:1983-10-01 00:00:00

  • Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels.

    abstract::Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.12.1401

    authors: Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

    更新日期:1982-12-01 00:00:00

  • Ictal motor signs and interictal regional cerebral hypometabolism.

    abstract::Early motor manifestations are the main components of focal seizures involving the frontal lobe. We examined the relationship between the initial ictal motor manifestations and interictal abnormalities of cerebral glucose consumption (rCMRGlc) as assessed by PET in 48 consecutive patients with focal seizures of neocor...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.2.341

    authors: Schlaug G,Antke C,Holthausen H,Arnold S,Ebner A,Tuxhorn I,Jäncke L,Lüders H,Witte OW,Seitz RJ

    更新日期:1997-08-01 00:00:00

  • Interrater reliability in the neuropathologic diagnosis of Alzheimer's disease.

    abstract::Three neuropathologists evaluated brain sections from 43 aged subjects for the presence of Alzheimer's disease. Moderate-to-substantial agreement was obtained. After discussion of disparate diagnoses, agreement was almost perfect for standardized and substantial for personal criteria. We conclude that reproducibility ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.2.329

    authors: Paulus W,Bancher C,Jellinger K

    更新日期:1992-02-01 00:00:00

  • Is there a neurologist on this flight?

    abstract:OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.58.12.1739

    authors: Sirven JI,Claypool DW,Sahs KL,Wingerchuk DM,Bortz JJ,Drazkowski J,Caselli R,Zanick D

    更新日期:2002-06-25 00:00:00

  • Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging.

    abstract::We report on the prevalence of dementia in Canadians age 85 years and older. The purpose of this study was to determine whether the prevalence of dementia continued to increase in the very old, and to define the types of dementia and their relative proportions in this age group. We collected data as part of the Canadi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.9.1593

    authors: Ebly EM,Parhad IM,Hogan DB,Fung TS

    更新日期:1994-09-01 00:00:00

  • Infections and course of disease in mild forms of Guillain-Barré syndrome.

    abstract:OBJECTIVE:Twenty-eight percent of patients with the Guillain-Barré syndrome remain able to walk unaided. Studying patients with the mild form of Guillain-Barré syndrome can further contribute to knowledge of the spectrum of the syndrome and explore whether this subgroup may need treatment with IV immunoglobulin. METHO...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/wnl.58.4.610

    authors: Van Koningsveld R,Schmitz PI,Ang CW,Groen J,Osterhaus AD,Van der Meché FG,Van Doorn PA

    更新日期:2002-02-26 00:00:00

  • Adult fucosidosis: histochemical and ultrastructural studies of rectal mucosa biopsy.

    abstract::Three sisters with adult fucosidosis showed prominent psychomotor retardation, gargoyle features, and angiokeratoma corporis diffusum, meeting the criteria for type II fucosidosis. By histochemical and ultrastructural studies, biopsy of rectal mucosa revealed many abnormal macrophages that were filled with fucose-rich...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.4.451

    authors: Ikeda S,Kondo K,Oguchi K,Yanagisawa N,Horigome R,Murata F

    更新日期:1984-04-01 00:00:00

  • Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients.

    abstract:BACKGROUND:Given that vagal afferents project to brainstem regions that promote alertness, the authors tested the hypothesis that vagus nerve stimulation (VNS) would improve daytime sleepiness in patients with epilepsy. METHODS:Sixteen subjects with medically refractory seizures underwent polysomnography and multiple ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.5.879

    authors: Malow BA,Edwards J,Marzec M,Sagher O,Ross D,Fromes G

    更新日期:2001-09-11 00:00:00

  • Prion disease incidence in the United States: 2003-2015.

    abstract:OBJECTIVE:To report the incidence of prion disease in the United States. METHODS:Prion disease decedents were retrospectively identified from the US national multiple cause-of-death data for 2003-2015 and matched with decedents in the National Prion Disease Pathology Surveillance Center (NPDPSC) database through compa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008680

    authors: Maddox RA,Person MK,Blevins JE,Abrams JY,Appleby BS,Schonberger LB,Belay ED

    更新日期:2020-01-14 00:00:00

  • Sturge-Weber syndrome: indications and results of surgery in 20 patients.

    abstract:OBJECTIVE:To discuss the indications and timing for resective surgery in patients with Sturge-Weber syndrome (SWS) and medication-resistant epilepsy. BACKGROUND:SWS that causes epilepsy severe enough to merit surgery is rare. Because of the variable natural history of the disease, it is difficult to establish clear-cu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.10.1472

    authors: Arzimanoglou AA,Andermann F,Aicardi J,Sainte-Rose C,Beaulieu MA,Villemure JG,Olivier A,Rasmussen T

    更新日期:2000-11-28 00:00:00

  • Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice.

    abstract::We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.6.990

    authors: Walton NY,Treiman DM

    更新日期:1990-06-01 00:00:00

  • Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

    abstract:OBJECTIVE:To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality. METHODS:In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Me...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000350

    authors: Benito-León J,Romero JP,Louis ED,Bermejo-Pareja F

    更新日期:2014-04-22 00:00:00

  • Use of β2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease.

    abstract:OBJECTIVE:To verify the previously reported association between long-term use of β2-adrenoreceptor (β2AR) agonist and antagonist with reduced and increased risk of Parkinson disease (PD), respectively. METHODS:We obtained odds ratios (ORs) associating time of β2AR agonist and antagonist use with PD risk in nationwide ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007694

    authors: Hopfner F,Wod M,Höglinger GU,Blaabjerg M,Rösler TW,Kuhlenbäumer G,Christensen K,Deuschl G,Pottegård A

    更新日期:2019-07-09 00:00:00

  • Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity.

    abstract::Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.5.1428

    authors: Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

    更新日期:1998-05-01 00:00:00

  • Nerve regeneration patterns after acute ischemic injury.

    abstract::We performed morphologic studies on regeneration of the cat's hind limb nerves, following simultaneous ligation of the aorta and right femoral artery. There were 2 regeneration patterns depending on the extent of ischemic necrosis. When nerve infarcts were limited only to intrafascicular regions, there was no basic ch...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.7.932

    authors: Korthals JK,Gieron MA,Wisniewski HM

    更新日期:1989-07-01 00:00:00

  • Psychiatric adverse events during levetiracetam therapy.

    abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000078031.32904.0d

    authors: Mula M,Trimble MR,Yuen A,Liu RS,Sander JW

    更新日期:2003-09-09 00:00:00

  • Genetic risk variants in African Americans with multiple sclerosis.

    abstract:OBJECTIVES:To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls). METHODS:Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single nucleotide polymorphism (SNP) genotyping was conducte...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31829bfe2f

    authors: Isobe N,Gourraud PA,Harbo HF,Caillier SJ,Santaniello A,Khankhanian P,Maiers M,Spellman S,Cereb N,Yang S,Pando MJ,Piccio L,Cross AH,De Jager PL,Cree BA,Hauser SL,Oksenberg JR

    更新日期:2013-07-16 00:00:00

  • Ischemic stroke subtypes among Mexican Americans and non-Hispanic whites: the BASIC Project.

    abstract::Ischemic stroke subtype distribution was compared between Mexican Americans (MAs) and non-Hispanic whites (NHWs) in a community-based stroke surveillance study in Nueces County, TX. There was no difference in the distribution of stroke subtype by ethnicity (p = 0.19). There was a similar proportion of small-vessel and...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000133212.99040.07

    authors: Uchino K,Risser JM,Smith MA,Moyé LA,Morgenstern LB

    更新日期:2004-08-10 00:00:00

  • Competency to consent to medical treatment in cognitively impaired patients with Parkinson's disease.

    abstract:OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.1.17

    authors: Dymek MP,Atchison P,Harrell L,Marson DC

    更新日期:2001-01-09 00:00:00

  • The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study.

    abstract::In 41 cases of verified ruptured saccular aneurysm, we prospectively predicted the presence or absence of delayed symptomatic cerebral vasospasm. CT criteria quantifying the extent and location of subarachnoid blood (developed in our previous retrospective study) were used in this prospective series of patients. Twent...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.4.424

    authors: Kistler JP,Crowell RM,Davis KR,Heros R,Ojemann RG,Zervas T,Fisher CM

    更新日期:1983-04-01 00:00:00